FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799594560> ?p ?o ?g. }

• W2799594560 endingPage "915" @default.
• W2799594560 startingPage "908" @default.
• W2799594560 abstract "Summary Activation of TRPV 4 (transient receptor potential vanilloid 4) has been reported to result in endothelium‐dependent contraction in the aortae of hypertensive mice. This contraction involved increased cPLA 2 (cytosolic phospholipase A 2 ) activity. The mechanism by which TRPV 4 regulates cPLA 2 activity to induce contraction in hypertension, however, is unknown. Through measurements of arterial tension and protein level, we showed that high‐salt diet induced hypertension increases activity of PKC (protein kinase C) and ERK 1/2 (extracellular signal‐regulated kinase 1/2). GSK 1016790A, a TRPV 4 agonist and AC h (acetylcholine) induced contractions were suppressed by Go6983, a PKC inhibitor and PD 98059, an ERK 1/2 inhibitor. TRPV 4 activation increased activity of PKC and ERK 1/2 in endothelial cells from hypertensive mice and this response was suppressed by HC 067047, a TRPV 4 inhibitor and BAPTA / AM , a Ca 2+ chelator. PLA 2 assay and western blotting showed that blocking of PKC or ERK 1/2 inhibited TRPV 4 or AC h‐induced cPLA 2 activity. Enzyme immunoassay showed that GSK 1016790A or AC h triggered the release of PGF 2α (prostaglandin F 2α ) was reduced by inhibition of PKC or ERK 1/2. These data further suggest Ca 2+ / PKC / ERK 1/2 axis as a novel mechanism for TRPV 4 in the activation of cPLA 2 in hypertension." @default.
• W2799594560 created "2018-05-17" @default.
• W2799594560 creator A5006636403 @default.
• W2799594560 creator A5010734160 @default.
• W2799594560 creator A5027516450 @default.
• W2799594560 creator A5035804461 @default.
• W2799594560 creator A5041131049 @default.
• W2799594560 creator A5048068113 @default.
• W2799594560 creator A5075263470 @default.
• W2799594560 creator A5089516092 @default.
• W2799594560 date "2018-06-21" @default.
• W2799594560 modified "2023-10-15" @default.
• W2799594560 title "TRPV4 activates cytosolic phospholipase A₂ via Ca²⁺ -dependent PKC/ERK1/2 signalling in controlling hypertensive contraction" @default.
• W2799594560 cites W1911830000 @default.
• W2799594560 cites W1971669463 @default.
• W2799594560 cites W1978869489 @default.
• W2799594560 cites W1991173655 @default.
• W2799594560 cites W1995865956 @default.
• W2799594560 cites W2007885739 @default.
• W2799594560 cites W2014152577 @default.
• W2799594560 cites W2019188478 @default.
• W2799594560 cites W2040501484 @default.
• W2799594560 cites W2048492290 @default.
• W2799594560 cites W2066796682 @default.
• W2799594560 cites W2076486276 @default.
• W2799594560 cites W2093533236 @default.
• W2799594560 cites W2094882741 @default.
• W2799594560 cites W2096552728 @default.
• W2799594560 cites W2102933238 @default.
• W2799594560 cites W2103478958 @default.
• W2799594560 cites W2123869725 @default.
• W2799594560 cites W2124568519 @default.
• W2799594560 cites W2126624423 @default.
• W2799594560 cites W2127224725 @default.
• W2799594560 cites W2134649384 @default.
• W2799594560 cites W2136538833 @default.
• W2799594560 cites W2146203772 @default.
• W2799594560 cites W2162184508 @default.
• W2799594560 cites W2169182236 @default.
• W2799594560 cites W2461724941 @default.
• W2799594560 cites W2583313510 @default.
• W2799594560 cites W2754772498 @default.
• W2799594560 cites W2767810159 @default.
• W2799594560 doi "https://doi.org/10.1111/1440-1681.12959" @default.
• W2799594560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29701904" @default.
• W2799594560 hasPublicationYear "2018" @default.
• W2799594560 type Work @default.
• W2799594560 sameAs 2799594560 @default.
• W2799594560 citedByCount "10" @default.
• W2799594560 countsByYear W27995945602018 @default.
• W2799594560 countsByYear W27995945602019 @default.
• W2799594560 countsByYear W27995945602020 @default.
• W2799594560 countsByYear W27995945602021 @default.
• W2799594560 countsByYear W27995945602022 @default.
• W2799594560 crossrefType "journal-article" @default.
• W2799594560 hasAuthorship W2799594560A5006636403 @default.
• W2799594560 hasAuthorship W2799594560A5010734160 @default.
• W2799594560 hasAuthorship W2799594560A5027516450 @default.
• W2799594560 hasAuthorship W2799594560A5035804461 @default.
• W2799594560 hasAuthorship W2799594560A5041131049 @default.
• W2799594560 hasAuthorship W2799594560A5048068113 @default.
• W2799594560 hasAuthorship W2799594560A5075263470 @default.
• W2799594560 hasAuthorship W2799594560A5089516092 @default.
• W2799594560 hasConcept C126322002 @default.
• W2799594560 hasConcept C134018914 @default.
• W2799594560 hasConcept C155164980 @default.
• W2799594560 hasConcept C160145004 @default.
• W2799594560 hasConcept C163415756 @default.
• W2799594560 hasConcept C170493617 @default.
• W2799594560 hasConcept C181199279 @default.
• W2799594560 hasConcept C184235292 @default.
• W2799594560 hasConcept C185592680 @default.
• W2799594560 hasConcept C195794163 @default.
• W2799594560 hasConcept C2776551241 @default.
• W2799594560 hasConcept C2778597717 @default.
• W2799594560 hasConcept C55493867 @default.
• W2799594560 hasConcept C57074206 @default.
• W2799594560 hasConcept C62478195 @default.
• W2799594560 hasConcept C71924100 @default.
• W2799594560 hasConcept C86803240 @default.
• W2799594560 hasConcept C87649029 @default.
• W2799594560 hasConcept C95444343 @default.
• W2799594560 hasConcept C98274493 @default.
• W2799594560 hasConceptScore W2799594560C126322002 @default.
• W2799594560 hasConceptScore W2799594560C134018914 @default.
• W2799594560 hasConceptScore W2799594560C155164980 @default.
• W2799594560 hasConceptScore W2799594560C160145004 @default.
• W2799594560 hasConceptScore W2799594560C163415756 @default.
• W2799594560 hasConceptScore W2799594560C170493617 @default.
• W2799594560 hasConceptScore W2799594560C181199279 @default.
• W2799594560 hasConceptScore W2799594560C184235292 @default.
• W2799594560 hasConceptScore W2799594560C185592680 @default.
• W2799594560 hasConceptScore W2799594560C195794163 @default.
• W2799594560 hasConceptScore W2799594560C2776551241 @default.
• W2799594560 hasConceptScore W2799594560C2778597717 @default.
• W2799594560 hasConceptScore W2799594560C55493867 @default.
• W2799594560 hasConceptScore W2799594560C57074206 @default.
• W2799594560 hasConceptScore W2799594560C62478195 @default.

• next