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- W2799655462 abstract "Prognostic value of microRNAs in colorectal cancer: a meta-analysis Song Gao,1,* Zhi-Ying Zhao,2,* Rong Wu,1 Yue Zhang,3 Zhen-Yong Zhang1 1Second Department of Clinical Oncology, Shengjing Hospital of China Medical University, 2School of Computer Science and Engineering, Northeastern University, Shenyang, 3First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China *These authors contributed equally to this work Background: Numerous studies have shown that miRNA levels are closely related to the survival time of patients with colon, rectal, or colorectal cancer (CRC). However, the outcomes of different investigations have been inconsistent. Accordingly, a meta-analysis was conducted to study associations among the three types of cancers.Materials and methods: Studies published in English that estimated the expression levels of miRNAs with survival curves in CRC were identified until May 20, 2017 by online searches in PubMed, Embase, Web of Science, and the Cochrane Library by two independent authors. Pooled HRs with 95% CIs were used to estimate the correlation between miRNA expression and overall survival.Results: A total of 63 relevant articles regarding 13 different miRNAs, with 10,254 patients were ultimately included. CRC patients with high expression of blood miR141 (HR 2.52, 95% CI 1.68–3.77), tissue miR21 (HR 1.31, 95% CI 1.12–1.53), miR181a (HR 1.52, 95% CI 1.26–1.83), or miR224 (HR 2.12, 95% CI 1.04–4.34), or low expression of tissue miR126 (HR 1.55, 95% CI 1.24–1.93) had significantly poor overall survival (P" @default.
- W2799655462 created "2018-05-17" @default.
- W2799655462 creator A5019515156 @default.
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- W2799655462 creator A5038634279 @default.
- W2799655462 creator A5067736387 @default.
- W2799655462 creator A5070972876 @default.
- W2799655462 date "2018-04-01" @default.
- W2799655462 modified "2023-10-16" @default.
- W2799655462 title "Prognostic value of microRNAs in colorectal cancer: a meta-analysis" @default.
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