FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799661819> ?p ?o ?g. }

• W2799661819 endingPage "1327" @default.
• W2799661819 startingPage "1319" @default.
• W2799661819 abstract "Abstract Background In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy of treatment, which depends on timely and safe surgery, is not well established. Methods This was a retrospective review of diagnostic and clinicopathological outcomes of prophylactic thyroidectomy in children with MEN2 between 1995 and 2013 in the UK. American Thyroid Association (ATA) 2009 guidelines were used as a benchmark for adequate treatment. Results Seventy-nine children from 16 centres underwent total thyroidectomy. Thirty-eight patients (48 per cent) underwent genetic testing and 36 (46 per cent) had an operation performed above the age recommended by the ATA 2009 guidelines; pathology showed MTC in 30 patients (38 per cent). Late surgery, above-normal preoperative calcitonin level and MTC on pathology correlated with late genetic testing. Twenty-five children had lymphadenectomy; these patients had more parathyroid glands excised (mean difference 0·61, 95 per cent c.i. 0·24 to 0·98; P = 0·001), and were more likely to have hypocalcaemia requiring medication (relative risk (RR) 3·12, 95 per cent c.i. 1·54 to 6·32; P = 0·002) and permanent hypoparathyroidism (RR 3·24, 1·29 to 8·11; P = 0·010) compared with those who underwent total thyroidectomy alone. Age did not influence the development of complications. Conclusion Late genetic testing may preclude age-appropriate surgery, increasing the risk of operating when MTC has already developed. Early genetic testing and age-appropriate surgery may help avoid unnecessary lymphadenectomy and improve outcomes." @default.
• W2799661819 created "2018-05-17" @default.
• W2799661819 creator A5003963194 @default.
• W2799661819 creator A5010641143 @default.
• W2799661819 creator A5059890127 @default.
• W2799661819 creator A5079422778 @default.
• W2799661819 creator A5090050235 @default.
• W2799661819 date "2018-04-17" @default.
• W2799661819 modified "2023-10-02" @default.
• W2799661819 title "Prophylactic thyroidectomy in children with multiple endocrine neoplasia type 2" @default.
• W2799661819 cites W1516747650 @default.
• W2799661819 cites W1594241115 @default.
• W2799661819 cites W1977117787 @default.
• W2799661819 cites W1981565562 @default.
• W2799661819 cites W1986046190 @default.
• W2799661819 cites W1989888312 @default.
• W2799661819 cites W2010292476 @default.
• W2799661819 cites W2012836080 @default.
• W2799661819 cites W2025526034 @default.
• W2799661819 cites W2031238707 @default.
• W2799661819 cites W2036874909 @default.
• W2799661819 cites W2037467402 @default.
• W2799661819 cites W2053454165 @default.
• W2799661819 cites W2083639781 @default.
• W2799661819 cites W2091849900 @default.
• W2799661819 cites W2093618117 @default.
• W2799661819 cites W2096998881 @default.
• W2799661819 cites W2113328339 @default.
• W2799661819 cites W2126481448 @default.
• W2799661819 cites W2157468795 @default.
• W2799661819 cites W2301331577 @default.
• W2799661819 cites W2315406683 @default.
• W2799661819 cites W2317439190 @default.
• W2799661819 cites W2331260641 @default.
• W2799661819 cites W2613463840 @default.
• W2799661819 cites W2978737563 @default.
• W2799661819 cites W4232865138 @default.
• W2799661819 cites W4251841769 @default.
• W2799661819 doi "https://doi.org/10.1002/bjs.10856" @default.
• W2799661819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29663329" @default.
• W2799661819 hasPublicationYear "2018" @default.
• W2799661819 type Work @default.
• W2799661819 sameAs 2799661819 @default.
• W2799661819 citedByCount "27" @default.
• W2799661819 countsByYear W27996618192018 @default.
• W2799661819 countsByYear W27996618192019 @default.
• W2799661819 countsByYear W27996618192020 @default.
• W2799661819 countsByYear W27996618192021 @default.
• W2799661819 countsByYear W27996618192022 @default.
• W2799661819 countsByYear W27996618192023 @default.
• W2799661819 crossrefType "journal-article" @default.
• W2799661819 hasAuthorship W2799661819A5003963194 @default.
• W2799661819 hasAuthorship W2799661819A5010641143 @default.
• W2799661819 hasAuthorship W2799661819A5059890127 @default.
• W2799661819 hasAuthorship W2799661819A5079422778 @default.
• W2799661819 hasAuthorship W2799661819A5090050235 @default.
• W2799661819 hasBestOaLocation W27996618192 @default.
• W2799661819 hasConcept C104317684 @default.
• W2799661819 hasConcept C126322002 @default.
• W2799661819 hasConcept C13514818 @default.
• W2799661819 hasConcept C141071460 @default.
• W2799661819 hasConcept C185592680 @default.
• W2799661819 hasConcept C2775941721 @default.
• W2799661819 hasConcept C2776512331 @default.
• W2799661819 hasConcept C2777074255 @default.
• W2799661819 hasConcept C2778812048 @default.
• W2799661819 hasConcept C2780103800 @default.
• W2799661819 hasConcept C2780673598 @default.
• W2799661819 hasConcept C3017431592 @default.
• W2799661819 hasConcept C44249647 @default.
• W2799661819 hasConcept C501734568 @default.
• W2799661819 hasConcept C519063684 @default.
• W2799661819 hasConcept C526584372 @default.
• W2799661819 hasConcept C55493867 @default.
• W2799661819 hasConcept C71924100 @default.
• W2799661819 hasConcept C82789193 @default.
• W2799661819 hasConceptScore W2799661819C104317684 @default.
• W2799661819 hasConceptScore W2799661819C126322002 @default.
• W2799661819 hasConceptScore W2799661819C13514818 @default.
• W2799661819 hasConceptScore W2799661819C141071460 @default.
• W2799661819 hasConceptScore W2799661819C185592680 @default.
• W2799661819 hasConceptScore W2799661819C2775941721 @default.
• W2799661819 hasConceptScore W2799661819C2776512331 @default.
• W2799661819 hasConceptScore W2799661819C2777074255 @default.
• W2799661819 hasConceptScore W2799661819C2778812048 @default.
• W2799661819 hasConceptScore W2799661819C2780103800 @default.
• W2799661819 hasConceptScore W2799661819C2780673598 @default.
• W2799661819 hasConceptScore W2799661819C3017431592 @default.
• W2799661819 hasConceptScore W2799661819C44249647 @default.
• W2799661819 hasConceptScore W2799661819C501734568 @default.
• W2799661819 hasConceptScore W2799661819C519063684 @default.
• W2799661819 hasConceptScore W2799661819C526584372 @default.
• W2799661819 hasConceptScore W2799661819C55493867 @default.
• W2799661819 hasConceptScore W2799661819C71924100 @default.
• W2799661819 hasConceptScore W2799661819C82789193 @default.
• W2799661819 hasIssue "10" @default.
• W2799661819 hasLocation W27996618191 @default.
• W2799661819 hasLocation W27996618192 @default.

• next