FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799667499> ?p ?o ?g. }

• W2799667499 endingPage "493" @default.
• W2799667499 startingPage "485" @default.
• W2799667499 abstract "Background HCV infections can now be completely cured, thanks to the currently marketed direct-acting antivirals (DAAs). It is known that HCV patients carry viral populations with baseline polymorphisms and/or mutations that make them resistant against some of these DAAs, which can negatively impact the patient's treatment outcome. Using complete HCV coding sequences isolated from 1,306 treatment-naive patients of genotypes (GTs) 1, 2, 3, 4 and 6 from around the globe, we studied the prevalence of baseline resistance-associated polymorphisms (RAPs) and resistance mutations (RMs) against DAAs that are currently on the market or in clinical trials. Methods The HCV genome sequences used in this study were retrieved from the NCBI database. RAPs and RMs, with reference to HCV GT1a, were identified using the HCV Geno2pheno web server. Results Nearly 50% of the total amino acid positions (including NS3 protease, NS5A and NS5B) studied are baseline polymorphisms that differentiated one GT from the rest. A proportion of these baseline polymorphisms and baseline non-polymorphic RMs could confer a significant increase in resistance against DAAs. Conclusions In this study, we show the presence and prevalence of RAPs and RMs in DAA treatment-naive patients against currently used DAAs or DAAs in clinical trials. Our study suggests that RAPs and RMs profiling of HCV patients should be performed before the start of the therapy. Our results should be relevant especially in low- and middle-income countries, where the patients have a large variation of GTs and subtypes, and where the generic HCV treatment is now increasingly available." @default.
• W2799667499 created "2018-05-17" @default.
• W2799667499 creator A5001373612 @default.
• W2799667499 creator A5008273778 @default.
• W2799667499 creator A5009181517 @default.
• W2799667499 creator A5024301634 @default.
• W2799667499 creator A5045791329 @default.
• W2799667499 creator A5067909526 @default.
• W2799667499 creator A5077357809 @default.
• W2799667499 date "2017-08-01" @default.
• W2799667499 modified "2023-10-18" @default.
• W2799667499 title "Worldwide Prevalence of Baseline Resistance-Associated Polymorphisms and Resistance Mutations in HCV against Current Direct-Acting Antivirals" @default.
• W2799667499 cites W1826210767 @default.
• W2799667499 cites W1968542367 @default.
• W2799667499 cites W1975166422 @default.
• W2799667499 cites W1982315879 @default.
• W2799667499 cites W1984181769 @default.
• W2799667499 cites W1990127122 @default.
• W2799667499 cites W2003780225 @default.
• W2799667499 cites W2019523835 @default.
• W2799667499 cites W2040621556 @default.
• W2799667499 cites W2052533488 @default.
• W2799667499 cites W2098368373 @default.
• W2799667499 cites W2107538559 @default.
• W2799667499 cites W2123893936 @default.
• W2799667499 cites W2127685726 @default.
• W2799667499 cites W2128260028 @default.
• W2799667499 cites W2133036275 @default.
• W2799667499 cites W2139172730 @default.
• W2799667499 cites W2143630391 @default.
• W2799667499 cites W2149722964 @default.
• W2799667499 cites W2152952856 @default.
• W2799667499 cites W2153783362 @default.
• W2799667499 cites W2157702265 @default.
• W2799667499 cites W2167049708 @default.
• W2799667499 cites W2168068623 @default.
• W2799667499 cites W2170919492 @default.
• W2799667499 cites W2209281674 @default.
• W2799667499 cites W2294421604 @default.
• W2799667499 cites W2317469439 @default.
• W2799667499 cites W2345381660 @default.
• W2799667499 cites W2397427953 @default.
• W2799667499 cites W2461004176 @default.
• W2799667499 cites W2538194643 @default.
• W2799667499 cites W2578013986 @default.
• W2799667499 cites W2588942442 @default.
• W2799667499 cites W2613899210 @default.
• W2799667499 cites W2765212316 @default.
• W2799667499 doi "https://doi.org/10.3851/imp3237" @default.
• W2799667499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29745936" @default.
• W2799667499 hasPublicationYear "2017" @default.
• W2799667499 type Work @default.
• W2799667499 sameAs 2799667499 @default.
• W2799667499 citedByCount "15" @default.
• W2799667499 countsByYear W27996674992018 @default.
• W2799667499 countsByYear W27996674992019 @default.
• W2799667499 countsByYear W27996674992020 @default.
• W2799667499 countsByYear W27996674992021 @default.
• W2799667499 countsByYear W27996674992022 @default.
• W2799667499 crossrefType "journal-article" @default.
• W2799667499 hasAuthorship W2799667499A5001373612 @default.
• W2799667499 hasAuthorship W2799667499A5008273778 @default.
• W2799667499 hasAuthorship W2799667499A5009181517 @default.
• W2799667499 hasAuthorship W2799667499A5024301634 @default.
• W2799667499 hasAuthorship W2799667499A5045791329 @default.
• W2799667499 hasAuthorship W2799667499A5067909526 @default.
• W2799667499 hasAuthorship W2799667499A5077357809 @default.
• W2799667499 hasConcept C104317684 @default.
• W2799667499 hasConcept C126322002 @default.
• W2799667499 hasConcept C135763542 @default.
• W2799667499 hasConcept C156719811 @default.
• W2799667499 hasConcept C159047783 @default.
• W2799667499 hasConcept C182707283 @default.
• W2799667499 hasConcept C2522874641 @default.
• W2799667499 hasConcept C2776408679 @default.
• W2799667499 hasConcept C2777103181 @default.
• W2799667499 hasConcept C2778986448 @default.
• W2799667499 hasConcept C2780040827 @default.
• W2799667499 hasConcept C2781426373 @default.
• W2799667499 hasConcept C2781463415 @default.
• W2799667499 hasConcept C49105822 @default.
• W2799667499 hasConcept C54355233 @default.
• W2799667499 hasConcept C71924100 @default.
• W2799667499 hasConcept C86803240 @default.
• W2799667499 hasConceptScore W2799667499C104317684 @default.
• W2799667499 hasConceptScore W2799667499C126322002 @default.
• W2799667499 hasConceptScore W2799667499C135763542 @default.
• W2799667499 hasConceptScore W2799667499C156719811 @default.
• W2799667499 hasConceptScore W2799667499C159047783 @default.
• W2799667499 hasConceptScore W2799667499C182707283 @default.
• W2799667499 hasConceptScore W2799667499C2522874641 @default.
• W2799667499 hasConceptScore W2799667499C2776408679 @default.
• W2799667499 hasConceptScore W2799667499C2777103181 @default.
• W2799667499 hasConceptScore W2799667499C2778986448 @default.
• W2799667499 hasConceptScore W2799667499C2780040827 @default.
• W2799667499 hasConceptScore W2799667499C2781426373 @default.
• W2799667499 hasConceptScore W2799667499C2781463415 @default.
• W2799667499 hasConceptScore W2799667499C49105822 @default.

• next