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- W2799673576 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers with very few available treatments. For many decades, gemcitabine was the only treatment for patients with PDAC. A recent attempt to improve patient survival by combining this chemotherapy with FOLFIRINOX and nab-paclitaxel failed and instead resulted in increased toxicity. Novel therapies are urgently required to improve PDAC patient survival. New treatments in other cancers such as melanoma, non-small cell lung cancer and renal cancer have emerged, based on immunotherapy targeting the immune checkpoints cytotoxic T-lymphocyte–associated antigen 4 (CTLA4) or programmed death 1 ligand (PDL1). However, the first clinical trials using such immune checkpoint inhibitors in PDAC have had limited success. Resistance to immunotherapy in PDAC remains unclear but could be due to tissue components (cancer-associated fibroblasts, desmoplasia, hypoxia) and to the imbalance between immunosuppressive and effector immune populations in the tumor microenvironment. In this review we analyzed the presence of “good and bad immunological cops” in PDAC, and discussed the significance of changes in their balance." @default.
- W2799673576 created "2018-05-17" @default.
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- W2799673576 date "2018-05-14" @default.
- W2799673576 modified "2023-10-12" @default.
- W2799673576 title "Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment" @default.
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- W2799673576 doi "https://doi.org/10.3389/fimmu.2018.01044" @default.
- W2799673576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5960705" @default.
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- W2799673576 hasPublicationYear "2018" @default.
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