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• W2799680179 abstract "Colorectal carcinoma is a common malignant tumor occurring in the alimentary system. Despite developments of modern medicine, developed resistance to 5-fluorouracil (5-FU) may lead to poor prognosis. Herein, we aimed to explore the effects of beta-elemene on colorectal carcinoma cells (HCT116 and HT29) as well as the underlying mechanisms. Beta-elemene reduced cell viability and induced apoptosis in HCT116 and HT29 cells. Increased apoptosis following beta-elemene exposure was due to enhanced sensitivity to 5-FU through down-regulating miR-191. Expression of key kinases, including Wnt3a, and β-catenin, were down-regulated by beta-elemene through a miR-191 mechanism. Moreover, beta-elemene might improve resistance of colorectal carcinoma cells to 5-FU by down-regulating miR-191, thereby inhibiting the Wnt/β-catenin pathway." @default.
• W2799680179 created "2018-05-17" @default.
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• W2799680179 date "2018-05-08" @default.
• W2799680179 modified "2023-09-30" @default.
• W2799680179 title "<i>Retracted</i> : Beta‐elemene increases chemosensitivity to 5‐fluorouracil through down‐regulating microRNA‐191 expression in colorectal carcinoma cells" @default.
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• W2799680179 doi "https://doi.org/10.1002/jcb.26914" @default.
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• W2799680179 hasPublicationYear "2018" @default.
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