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• W2799682788 endingPage "933" @default.
• W2799682788 startingPage "933" @default.
• W2799682788 abstract "Transcription is a crucial step in the life cycle of the human immunodeficiency virus type 1 (HIV 1) and is primarily involved in the maintenance of viral latency. Both viral and cellular transcription factors, including transcriptional activators, suppressor proteins and epigenetic factors, are involved in HIV transcription from the proviral DNA integrated within the host cell genome. Among them, the virus-encoded transcriptional activator Tat is the master regulator of HIV transcription. Interestingly, unlike other known transcriptional activators, Tat primarily activates transcriptional elongation and initiation by interacting with the cellular positive transcriptional elongation factor b (P-TEFb). In this review, we describe the molecular mechanism underlying how Tat activates viral transcription through interaction with P-TEFb. We propose a novel therapeutic strategy against HIV replication through blocking Tat action." @default.
• W2799682788 created "2018-05-17" @default.
• W2799682788 creator A5011719864 @default.
• W2799682788 creator A5026093084 @default.
• W2799682788 creator A5080927780 @default.
• W2799682788 date "2018-04-17" @default.
• W2799682788 modified "2023-10-10" @default.
• W2799682788 title "HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies" @default.
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