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• W2799683916 startingPage "e0195969" @default.
• W2799683916 abstract "The RNA that is packaged into exosomes is termed as exosomal-shuttle RNA (esRNA); however, the players, which take this subset of RNA (esRNA) into exosomes, remain largely unknown. We hypothesized that RNA binding proteins (RBPs) could serve as key players in this mechanism, by making complexes with RNAs and transporting them into exosomes during the biosynthesis of exosomes. Here, we demonstrate the presence of 30 RBPs in exosomes that were shown to form RNA-RBP complexes with both cellular RNA and exosomal-RNA species. To assess the involvement of these RBPs in RNA-transfer into exosomes, the gene transcripts encoding six of the proteins identified in exosomes (HSP90AB1, XPO5, hnRNPH1, hnRNPM, hnRNPA2B1, and MVP) were silenced by siRNA and subsequent effect on esRNA was assessed. A significant reduction of total esRNA was observed by post-transcriptional silencing of MVP, compared to other RBPs. Furthermore, to confirm the binding of MVP with esRNA, a biotinylated-MVP was transiently expressed in HEK293F cells. Higher levels of esRNA were recovered from MVP that was eluted from exosomes of transfected cells, as compared to those of non-transfected cells. Our data indicate that these RBPs could end up in exosomes together with RNA molecules in the form of RNA-ribonucleoprotein complexes, which could be important for the transport of RNAs into exosomes and the maintenance of RNAs inside exosomes. This type of maintenance may favor the shuttling of RNAs from exosomes to recipient cells in the form of stable complexes." @default.
• W2799683916 created "2018-05-17" @default.
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• W2799683916 creator A5090657879 @default.
• W2799683916 date "2018-04-24" @default.
• W2799683916 modified "2023-10-14" @default.
• W2799683916 title "Identification of RNA-binding proteins in exosomes capable of interacting with different types of RNA: RBP-facilitated transport of RNAs into exosomes" @default.
• W2799683916 cites W1521676890 @default.
• W2799683916 cites W1533516721 @default.
• W2799683916 cites W1769060942 @default.
• W2799683916 cites W1832220924 @default.
• W2799683916 cites W1950118853 @default.
• W2799683916 cites W1965108432 @default.
• W2799683916 cites W1967367827 @default.
• W2799683916 cites W1971436788 @default.
• W2799683916 cites W1976641407 @default.
• W2799683916 cites W1977613047 @default.
• W2799683916 cites W1977692564 @default.
• W2799683916 cites W1983752521 @default.
• W2799683916 cites W1983970047 @default.
• W2799683916 cites W1984574291 @default.
• W2799683916 cites W1985175917 @default.
• W2799683916 cites W1985844219 @default.
• W2799683916 cites W1986630370 @default.
• W2799683916 cites W1990388063 @default.
• W2799683916 cites W1992991878 @default.
• W2799683916 cites W1994344811 @default.
• W2799683916 cites W1997535872 @default.
• W2799683916 cites W1999414203 @default.
• W2799683916 cites W1999925406 @default.
• W2799683916 cites W2004895989 @default.
• W2799683916 cites W2010052865 @default.
• W2799683916 cites W2013994555 @default.
• W2799683916 cites W2015387324 @default.
• W2799683916 cites W2024206172 @default.
• W2799683916 cites W2026878981 @default.
• W2799683916 cites W2029735360 @default.
• W2799683916 cites W2030701238 @default.
• W2799683916 cites W2031807756 @default.
• W2799683916 cites W2034207323 @default.
• W2799683916 cites W2037993016 @default.
• W2799683916 cites W2040351396 @default.
• W2799683916 cites W2055313665 @default.
• W2799683916 cites W2068876196 @default.
• W2799683916 cites W2070989134 @default.
• W2799683916 cites W2071097995 @default.
• W2799683916 cites W2073341747 @default.
• W2799683916 cites W2073556061 @default.
• W2799683916 cites W2076315676 @default.
• W2799683916 cites W2077878547 @default.
• W2799683916 cites W2082448279 @default.
• W2799683916 cites W2083171893 @default.
• W2799683916 cites W2084770914 @default.
• W2799683916 cites W2086275775 @default.
• W2799683916 cites W2087672655 @default.
• W2799683916 cites W2092340911 @default.
• W2799683916 cites W2101243726 @default.
• W2799683916 cites W2104902761 @default.
• W2799683916 cites W2107008239 @default.
• W2799683916 cites W2111019629 @default.
• W2799683916 cites W2111533160 @default.
• W2799683916 cites W2111560326 @default.
• W2799683916 cites W2127982146 @default.
• W2799683916 cites W2128384671 @default.
• W2799683916 cites W2128891846 @default.
• W2799683916 cites W2132589340 @default.
• W2799683916 cites W2136601868 @default.
• W2799683916 cites W2138401662 @default.
• W2799683916 cites W2148224382 @default.
• W2799683916 cites W2149423226 @default.
• W2799683916 cites W2154479094 @default.
• W2799683916 cites W2167586711 @default.
• W2799683916 cites W2167604259 @default.
• W2799683916 cites W2168326351 @default.
• W2799683916 cites W2170518899 @default.
• W2799683916 cites W2170852633 @default.
• W2799683916 cites W2170952313 @default.
• W2799683916 cites W2171264103 @default.
• W2799683916 cites W2171940778 @default.
• W2799683916 cites W2189401106 @default.
• W2799683916 cites W2259035271 @default.
• W2799683916 cites W2327541311 @default.
• W2799683916 cites W2340514456 @default.
• W2799683916 cites W2472591216 @default.
• W2799683916 cites W24924758 @default.

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