Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799688312> ?p ?o ?g. }
- W2799688312 endingPage "370" @default.
- W2799688312 startingPage "349" @default.
- W2799688312 abstract "Chromosome segregation relies on forces generated by spindle microtubules that are translated into chromosome movement through interactions with kinetochores, highly conserved macromolecular machines that assemble on a specialized centromeric chromatin structure. Kinetochores not only have to stably attach to growing and shrinking microtubules, but they also need to recruit spindle assembly checkpoint proteins to halt cell cycle progression when there are attachment defects. Even the simplest kinetochore in budding yeast contains more than 50 unique components that are present in multiple copies, totaling more than 250 proteins in a single kinetochore. The complex nature of kinetochores makes it challenging to elucidate the contributions of individual components to its various functions. In addition, it is difficult to manipulate forces in vivo to understand how they regulate kinetochore-microtubule attachments and the checkpoint. To address these issues, we developed a technique to purify kinetochores from budding yeast that can be used to analyze kinetochore functions and composition as well as to reconstitute kinetochore-microtubule attachments in vitro." @default.
- W2799688312 created "2018-05-17" @default.
- W2799688312 creator A5005300159 @default.
- W2799688312 creator A5011654255 @default.
- W2799688312 creator A5013093530 @default.
- W2799688312 creator A5017109332 @default.
- W2799688312 creator A5040395532 @default.
- W2799688312 date "2018-01-01" @default.
- W2799688312 modified "2023-10-01" @default.
- W2799688312 title "Purification of kinetochores from the budding yeast Saccharomyces cerevisiae" @default.
- W2799688312 cites W1963750681 @default.
- W2799688312 cites W1966942208 @default.
- W2799688312 cites W1967696278 @default.
- W2799688312 cites W1973916918 @default.
- W2799688312 cites W1995275121 @default.
- W2799688312 cites W2003187194 @default.
- W2799688312 cites W2005482024 @default.
- W2799688312 cites W2005510835 @default.
- W2799688312 cites W2018700509 @default.
- W2799688312 cites W2022046477 @default.
- W2799688312 cites W2025809825 @default.
- W2799688312 cites W2028118479 @default.
- W2799688312 cites W2036014201 @default.
- W2799688312 cites W2048938594 @default.
- W2799688312 cites W2055141106 @default.
- W2799688312 cites W2055168854 @default.
- W2799688312 cites W2059069459 @default.
- W2799688312 cites W2060642930 @default.
- W2799688312 cites W2062214822 @default.
- W2799688312 cites W2080258862 @default.
- W2799688312 cites W2080457024 @default.
- W2799688312 cites W2087298314 @default.
- W2799688312 cites W2089813569 @default.
- W2799688312 cites W2106320311 @default.
- W2799688312 cites W2108688550 @default.
- W2799688312 cites W2120122701 @default.
- W2799688312 cites W2120125134 @default.
- W2799688312 cites W2128918653 @default.
- W2799688312 cites W2133503471 @default.
- W2799688312 cites W2141309442 @default.
- W2799688312 cites W2146087376 @default.
- W2799688312 cites W2157980476 @default.
- W2799688312 cites W2168495075 @default.
- W2799688312 cites W2170145644 @default.
- W2799688312 cites W2175830921 @default.
- W2799688312 cites W2295027375 @default.
- W2799688312 cites W2345583633 @default.
- W2799688312 cites W2346372328 @default.
- W2799688312 cites W2542124795 @default.
- W2799688312 cites W2587723625 @default.
- W2799688312 cites W2612928848 @default.
- W2799688312 cites W2683561870 @default.
- W2799688312 cites W4229736484 @default.
- W2799688312 cites W4240065971 @default.
- W2799688312 doi "https://doi.org/10.1016/bs.mcb.2018.03.023" @default.
- W2799688312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205221" @default.
- W2799688312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29804677" @default.
- W2799688312 hasPublicationYear "2018" @default.
- W2799688312 type Work @default.
- W2799688312 sameAs 2799688312 @default.
- W2799688312 citedByCount "17" @default.
- W2799688312 countsByYear W27996883122018 @default.
- W2799688312 countsByYear W27996883122019 @default.
- W2799688312 countsByYear W27996883122020 @default.
- W2799688312 countsByYear W27996883122021 @default.
- W2799688312 countsByYear W27996883122022 @default.
- W2799688312 countsByYear W27996883122023 @default.
- W2799688312 crossrefType "book-chapter" @default.
- W2799688312 hasAuthorship W2799688312A5005300159 @default.
- W2799688312 hasAuthorship W2799688312A5011654255 @default.
- W2799688312 hasAuthorship W2799688312A5013093530 @default.
- W2799688312 hasAuthorship W2799688312A5017109332 @default.
- W2799688312 hasAuthorship W2799688312A5040395532 @default.
- W2799688312 hasBestOaLocation W27996883122 @default.
- W2799688312 hasConcept C104317684 @default.
- W2799688312 hasConcept C1491633281 @default.
- W2799688312 hasConcept C175732170 @default.
- W2799688312 hasConcept C192838845 @default.
- W2799688312 hasConcept C20418707 @default.
- W2799688312 hasConcept C2777576037 @default.
- W2799688312 hasConcept C2778354886 @default.
- W2799688312 hasConcept C2779222958 @default.
- W2799688312 hasConcept C30481170 @default.
- W2799688312 hasConcept C47432576 @default.
- W2799688312 hasConcept C54355233 @default.
- W2799688312 hasConcept C552990157 @default.
- W2799688312 hasConcept C70547292 @default.
- W2799688312 hasConcept C83640560 @default.
- W2799688312 hasConcept C85813293 @default.
- W2799688312 hasConcept C86803240 @default.
- W2799688312 hasConcept C93304396 @default.
- W2799688312 hasConcept C95444343 @default.
- W2799688312 hasConcept C9565192 @default.
- W2799688312 hasConceptScore W2799688312C104317684 @default.
- W2799688312 hasConceptScore W2799688312C1491633281 @default.
- W2799688312 hasConceptScore W2799688312C175732170 @default.
- W2799688312 hasConceptScore W2799688312C192838845 @default.
- W2799688312 hasConceptScore W2799688312C20418707 @default.