FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799690070> ?p ?o ?g. }

• W2799690070 endingPage "811" @default.
• W2799690070 startingPage "799" @default.
• W2799690070 abstract "Sloths are canopy-dwelling inhabitants of American neotropical rainforests that exhibit suspensory behaviors. These abilities require both strength and muscular endurance to hang for extended periods of time; however, the skeletal muscle mass of sloths is reduced, thus requiring modifications to muscle architecture and leverage for large joint torque. We hypothesize that intrinsic muscle properties are also modified for fatigue resistance and predict a heterogeneous expression of slow/fast myosin heavy chain (MHC) fibers that utilize oxidative metabolic pathways for economic force production. MHC fiber type distribution and energy metabolism in the forelimb muscles of three-toed ( Bradypus variegatus, n = 5) and two-toed ( Choloepus hoffmanni, n = 4) sloths were evaluated using SDS-PAGE, immunohistochemistry, and enzyme activity assays. The results partially support our hypothesis by a primary expression of the slow MHC-1 isoform as well as moderate expression of fast MHC-2A fibers, whereas few hybrid MHC-1/2A fibers were found in both species. MHC-1 fibers were larger in cross-sectional area (CSA) than MHC-2A fibers and comprised the greatest percentage of CSA in each muscle sampled. Enzyme assays showed elevated activity for the anaerobic enzymes creatine kinase and lactate dehydrogenase compared with low activity for aerobic markers citrate synthase and 3-hydroxyacetyl CoA dehydrogenase. These findings suggest that sloth forelimb muscles may rely heavily on rapid ATP resynthesis pathways, and lactate accumulation may be beneficial. The intrinsic properties observed match well with suspensory requirements, and these modifications may have further evolved in unison with low metabolism and slow movement patterns as means to systemically conserve energy. NEW & NOTEWORTHY Myosin heavy chain (MHC) fiber type and fiber metabolic properties were evaluated to understand the ability of sloths to remain suspended for extended periods without muscle fatigue. Broad distributions of large, slow MHC-1 fibers as well as small, fast MHC-2A fibers are expressed in sloth forelimbs, but muscle metabolism is generally not correlated with myosin fiber type or body size. Sloth muscles rely on rapid, anaerobic pathways to resist fatigue and sustain force production." @default.
• W2799690070 created "2018-05-17" @default.
• W2799690070 creator A5005523309 @default.
• W2799690070 creator A5023330833 @default.
• W2799690070 creator A5029372637 @default.
• W2799690070 creator A5029422718 @default.
• W2799690070 creator A5046320910 @default.
• W2799690070 creator A5065766990 @default.
• W2799690070 creator A5079698143 @default.
• W2799690070 creator A5082501717 @default.
• W2799690070 creator A5083828170 @default.
• W2799690070 date "2018-09-01" @default.
• W2799690070 modified "2023-10-15" @default.
• W2799690070 title "Cheap labor: myosin fiber type expression and enzyme activity in the forelimb musculature of sloths (Pilosa: Xenarthra)" @default.
• W2799690070 cites W1485655124 @default.
• W2799690070 cites W1508749874 @default.
• W2799690070 cites W1533486409 @default.
• W2799690070 cites W1568672997 @default.
• W2799690070 cites W1799879229 @default.
• W2799690070 cites W1966392477 @default.
• W2799690070 cites W1973024427 @default.
• W2799690070 cites W1973931381 @default.
• W2799690070 cites W1975658120 @default.
• W2799690070 cites W1980507616 @default.
• W2799690070 cites W1988964546 @default.
• W2799690070 cites W1992036272 @default.
• W2799690070 cites W1993133168 @default.
• W2799690070 cites W1998301159 @default.
• W2799690070 cites W2001652080 @default.
• W2799690070 cites W2003397662 @default.
• W2799690070 cites W2011173742 @default.
• W2799690070 cites W2020471163 @default.
• W2799690070 cites W2024201410 @default.
• W2799690070 cites W2027383289 @default.
• W2799690070 cites W2028086521 @default.
• W2799690070 cites W2033830901 @default.
• W2799690070 cites W2051371641 @default.
• W2799690070 cites W2055397626 @default.
• W2799690070 cites W2057999878 @default.
• W2799690070 cites W2059653039 @default.
• W2799690070 cites W2060562277 @default.
• W2799690070 cites W2060605880 @default.
• W2799690070 cites W2062834534 @default.
• W2799690070 cites W2065542016 @default.
• W2799690070 cites W2068206503 @default.
• W2799690070 cites W2069715270 @default.
• W2799690070 cites W2078660921 @default.
• W2799690070 cites W2080574622 @default.
• W2799690070 cites W2091260432 @default.
• W2799690070 cites W2096134121 @default.
• W2799690070 cites W2104848153 @default.
• W2799690070 cites W2107598271 @default.
• W2799690070 cites W2108480786 @default.
• W2799690070 cites W2126613115 @default.
• W2799690070 cites W2129159777 @default.
• W2799690070 cites W2130025116 @default.
• W2799690070 cites W2135850563 @default.
• W2799690070 cites W2145770517 @default.
• W2799690070 cites W2147745178 @default.
• W2799690070 cites W2157714820 @default.
• W2799690070 cites W2165485458 @default.
• W2799690070 cites W2175991112 @default.
• W2799690070 cites W2238032168 @default.
• W2799690070 cites W2401269469 @default.
• W2799690070 cites W2504502712 @default.
• W2799690070 cites W2588431016 @default.
• W2799690070 cites W2601804090 @default.
• W2799690070 cites W2604667823 @default.
• W2799690070 cites W2611424476 @default.
• W2799690070 cites W2760698437 @default.
• W2799690070 doi "https://doi.org/10.1152/japplphysiol.01118.2017" @default.
• W2799690070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29722617" @default.
• W2799690070 hasPublicationYear "2018" @default.
• W2799690070 type Work @default.
• W2799690070 sameAs 2799690070 @default.
• W2799690070 citedByCount "12" @default.
• W2799690070 countsByYear W27996900702020 @default.
• W2799690070 countsByYear W27996900702021 @default.
• W2799690070 countsByYear W27996900702022 @default.
• W2799690070 countsByYear W27996900702023 @default.
• W2799690070 crossrefType "journal-article" @default.
• W2799690070 hasAuthorship W2799690070A5005523309 @default.
• W2799690070 hasAuthorship W2799690070A5023330833 @default.
• W2799690070 hasAuthorship W2799690070A5029372637 @default.
• W2799690070 hasAuthorship W2799690070A5029422718 @default.
• W2799690070 hasAuthorship W2799690070A5046320910 @default.
• W2799690070 hasAuthorship W2799690070A5065766990 @default.
• W2799690070 hasAuthorship W2799690070A5079698143 @default.
• W2799690070 hasAuthorship W2799690070A5082501717 @default.
• W2799690070 hasAuthorship W2799690070A5083828170 @default.
• W2799690070 hasBestOaLocation W27996900701 @default.
• W2799690070 hasConcept C105702510 @default.
• W2799690070 hasConcept C2778646069 @default.
• W2799690070 hasConcept C55493867 @default.
• W2799690070 hasConcept C6997183 @default.
• W2799690070 hasConcept C7301908 @default.
• W2799690070 hasConcept C86803240 @default.
• W2799690070 hasConcept C95444343 @default.

• next