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- W2799690117 abstract "Abstract Modification of histones by acetylation plays a key role in the epigenetic regulation of gene expression, and is controlled by the balance between histone deacetylases (HDACs) and histone acetyltransferases (HATs). The process of histone acetylation is critically important in the regulation of many cellular processes including transcription, DNA replication and repair, cell cycle progression, differentiation, and apoptosis. A variety of nonhistone proteins are also targeted by HDACs, and while the specific mechanisms are complex, increased HDAC activity generally correlates with tumorigenesis. Inhibition of HDACs represents a new strategy in cancer therapy—chromatin remodeling—which is distinct from (but potentially synergistic with) chemotherapy and radiation. Drugs that are HDAC inhibitors (HDAC-Is) were initially found to reverse malignant properties of cancer cells, then used to better understand HDAC regulation of gene expression and the molecular pathways in neoplasia. HDAC-Is can be grouped into five families: (1) short chain fatty acids (SCFAs), (2) hydroxamic acids, (3) benzamides, (4) cyclic tetrapeptides, and (5) sirtuin inhibitors. To date, valproic acid and vorinostat are the two HDAC-Is which have been most extensively studied in neuro-oncology. HDAC-Is may be used as monotherapy or in combination with other agents. Several HDAC-Is have now been approved for use in patients with cancer. This chapter provides: (1) a review of the basic principles of the molecular biology of HDACs and HDAC-Is, and (2) a summary of HDAC-I preclinical studies and clinical trials having the most relevance for brain tumor patients." @default.
- W2799690117 created "2018-05-17" @default.
- W2799690117 creator A5001600608 @default.
- W2799690117 creator A5039890806 @default.
- W2799690117 creator A5056097889 @default.
- W2799690117 date "2018-01-01" @default.
- W2799690117 modified "2023-09-25" @default.
- W2799690117 title "Histone Deacetylase Inhibitors as Therapeutic Agents for Patients with Brain Tumors" @default.
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