Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799690945> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2799690945 abstract "Background/purpose Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by immune complexes, especially those with nuclear molecules bound by antinuclear antibodies. Although the source of these antigens is not fully known, increased apoptosis and defective clearance of dead cells have been proposed. During apoptosis and cell activation, microparticles (MPs) are released extracellularly. MPs are small membrane-bound particles that can contain molecules arising from both the nucleus and cytoplasm. Moreover, these MPs are often covered with immunoglobulins, thus forming MP-immune complexes (mpICs). Methods Plasma samples from 47 patients with SLE and 24 healthy controls were investigated. MPs and mpICs were analysed by flow cytometry and defined by size; MPs ( 0.7 µm). Samples were labelled with MitoTracker deep red FM to investigate mitochondrial content. Flow cytometry was also used to assess outer mitochondria markers Tom-20 and hexokinase I, as well as the presence of IgG. Results Levels of both MPs and mpICs in SLE patients were significantly elevated compared to controls (figure 1A). Although MP concentrations were higher than those of mpICs, mpICs contained more mitochondria compared to MPs (figure 1B). mpICs also displayed IgG and exposed the outer mitochondria markers. The number of mpICs containing mitochondria correlated strongly to the presence of anti-dsDNA antibodies (figure 2) as well as to levels of TNFα (r² 0.2, p Conclusion MPs and mpICs are significantly more abundant in the blood of SLE patients compared to controls. Importantly, the majority of the mitochondria were present in the larger mpIC sup-population. Moreover, mpICs that contain mitochondria also display outer mitochondria markers, with levels correlating with levels of anti-dsDNA antibodies, disease activity and pro-inflammatory cytokines. mpICs may therefore contribute to SLE pathogenesis, with mitochondria representing a source of cell antigens that can trigger innate and adaptive immune responses as well as deposit in the tissue." @default.
- W2799690945 created "2018-05-17" @default.
- W2799690945 creator A5015062757 @default.
- W2799690945 creator A5037276492 @default.
- W2799690945 creator A5049200752 @default.
- W2799690945 creator A5053954343 @default.
- W2799690945 creator A5075304688 @default.
- W2799690945 date "2018-03-01" @default.
- W2799690945 modified "2023-10-02" @default.
- W2799690945 title "S3A:6 Microparticles with mitochondrial molecules and immunoglobulins associate with active disease in systemic lupus erythematosus" @default.
- W2799690945 doi "https://doi.org/10.1136/lupus-2018-abstract.13" @default.
- W2799690945 hasPublicationYear "2018" @default.
- W2799690945 type Work @default.
- W2799690945 sameAs 2799690945 @default.
- W2799690945 citedByCount "0" @default.
- W2799690945 crossrefType "proceedings-article" @default.
- W2799690945 hasAuthorship W2799690945A5015062757 @default.
- W2799690945 hasAuthorship W2799690945A5037276492 @default.
- W2799690945 hasAuthorship W2799690945A5049200752 @default.
- W2799690945 hasAuthorship W2799690945A5053954343 @default.
- W2799690945 hasAuthorship W2799690945A5075304688 @default.
- W2799690945 hasBestOaLocation W27996909451 @default.
- W2799690945 hasConcept C142724271 @default.
- W2799690945 hasConcept C147483822 @default.
- W2799690945 hasConcept C149443304 @default.
- W2799690945 hasConcept C153911025 @default.
- W2799690945 hasConcept C159654299 @default.
- W2799690945 hasConcept C163764329 @default.
- W2799690945 hasConcept C185592680 @default.
- W2799690945 hasConcept C190062978 @default.
- W2799690945 hasConcept C190283241 @default.
- W2799690945 hasConcept C203014093 @default.
- W2799690945 hasConcept C2775915377 @default.
- W2799690945 hasConcept C2776912625 @default.
- W2799690945 hasConcept C2779134260 @default.
- W2799690945 hasConcept C2780130043 @default.
- W2799690945 hasConcept C2780380361 @default.
- W2799690945 hasConcept C28859421 @default.
- W2799690945 hasConcept C2908647359 @default.
- W2799690945 hasConcept C553184892 @default.
- W2799690945 hasConcept C55493867 @default.
- W2799690945 hasConcept C71924100 @default.
- W2799690945 hasConcept C86803240 @default.
- W2799690945 hasConcept C8891405 @default.
- W2799690945 hasConcept C95444343 @default.
- W2799690945 hasConcept C99454951 @default.
- W2799690945 hasConceptScore W2799690945C142724271 @default.
- W2799690945 hasConceptScore W2799690945C147483822 @default.
- W2799690945 hasConceptScore W2799690945C149443304 @default.
- W2799690945 hasConceptScore W2799690945C153911025 @default.
- W2799690945 hasConceptScore W2799690945C159654299 @default.
- W2799690945 hasConceptScore W2799690945C163764329 @default.
- W2799690945 hasConceptScore W2799690945C185592680 @default.
- W2799690945 hasConceptScore W2799690945C190062978 @default.
- W2799690945 hasConceptScore W2799690945C190283241 @default.
- W2799690945 hasConceptScore W2799690945C203014093 @default.
- W2799690945 hasConceptScore W2799690945C2775915377 @default.
- W2799690945 hasConceptScore W2799690945C2776912625 @default.
- W2799690945 hasConceptScore W2799690945C2779134260 @default.
- W2799690945 hasConceptScore W2799690945C2780130043 @default.
- W2799690945 hasConceptScore W2799690945C2780380361 @default.
- W2799690945 hasConceptScore W2799690945C28859421 @default.
- W2799690945 hasConceptScore W2799690945C2908647359 @default.
- W2799690945 hasConceptScore W2799690945C553184892 @default.
- W2799690945 hasConceptScore W2799690945C55493867 @default.
- W2799690945 hasConceptScore W2799690945C71924100 @default.
- W2799690945 hasConceptScore W2799690945C86803240 @default.
- W2799690945 hasConceptScore W2799690945C8891405 @default.
- W2799690945 hasConceptScore W2799690945C95444343 @default.
- W2799690945 hasConceptScore W2799690945C99454951 @default.
- W2799690945 hasLocation W27996909451 @default.
- W2799690945 hasOpenAccess W2799690945 @default.
- W2799690945 hasPrimaryLocation W27996909451 @default.
- W2799690945 hasRelatedWork W1917940007 @default.
- W2799690945 hasRelatedWork W1949185997 @default.
- W2799690945 hasRelatedWork W1974164284 @default.
- W2799690945 hasRelatedWork W1986002846 @default.
- W2799690945 hasRelatedWork W2014186007 @default.
- W2799690945 hasRelatedWork W2037902347 @default.
- W2799690945 hasRelatedWork W2038949218 @default.
- W2799690945 hasRelatedWork W2042713533 @default.
- W2799690945 hasRelatedWork W2074035698 @default.
- W2799690945 hasRelatedWork W2081838070 @default.
- W2799690945 hasRelatedWork W2101467927 @default.
- W2799690945 hasRelatedWork W2113168018 @default.
- W2799690945 hasRelatedWork W2130982543 @default.
- W2799690945 hasRelatedWork W2191538198 @default.
- W2799690945 hasRelatedWork W2886192086 @default.
- W2799690945 hasRelatedWork W2901074591 @default.
- W2799690945 hasRelatedWork W2944354478 @default.
- W2799690945 hasRelatedWork W2946782324 @default.
- W2799690945 hasRelatedWork W3003059684 @default.
- W2799690945 hasRelatedWork W315328246 @default.
- W2799690945 isParatext "false" @default.
- W2799690945 isRetracted "false" @default.
- W2799690945 magId "2799690945" @default.
- W2799690945 workType "article" @default.