FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799691218> ?p ?o ?g. }

• W2799691218 endingPage "2178" @default.
• W2799691218 startingPage "2172" @default.
• W2799691218 abstract "Pseudomonas aeruginosa is an opportunistic bacteria responsible for recurrent lung infections. Previously, we demonstrated that certain materials improved the activity of tobramycin (Tob) against P. aeruginosa biofilms in vitro. We aimed to develop prototype dry powder formulations comprising Tob and a mixture of excipients and test its aerodynamic properties and antimicrobial activity. First, we evaluated different combinations of excipients with Tob in solution against P. aeruginosa biofilms. We selected the compositions with the highest activity, to prepare dry powders by spray drying. The powders were characterized by morphology, bulk density, water content, and particle size distributions. Finally, the antimicrobial activity of the powders was tested. The combinations of Tob (64 μg/mL) with l-alanine and l-proline (at 10 and 20 mM; formulations 1 and 2, respectively) and with l-alanine and succinic acid (at 20 mM; formulation 3) showed the highest efficacies in vitro and were prepared as dry powders. Formulation 1 had the best aerodynamic performance as indicated by the fine particle fraction and the best in vitro activity against P. aeruginosa biofilms. Formulation 3 represents a good candidate for further optimization because it demonstrated good dispersibility potential and optimization of the particle size distribution may achieve high delivery efficiencies." @default.
• W2799691218 created "2018-05-17" @default.
• W2799691218 creator A5004480578 @default.
• W2799691218 creator A5023590664 @default.
• W2799691218 creator A5026110433 @default.
• W2799691218 creator A5034503760 @default.
• W2799691218 date "2018-08-01" @default.
• W2799691218 modified "2023-09-23" @default.
• W2799691218 title "Development, Characterization, and In Vitro Testing of Co-Delivered Antimicrobial Dry Powder Formulation for the Treatment of Pseudomonas aeruginosa Biofilms" @default.
• W2799691218 cites W1598431000 @default.
• W2799691218 cites W1924457892 @default.
• W2799691218 cites W1986108334 @default.
• W2799691218 cites W1987352989 @default.
• W2799691218 cites W1992629480 @default.
• W2799691218 cites W2001703603 @default.
• W2799691218 cites W2006907865 @default.
• W2799691218 cites W2007296377 @default.
• W2799691218 cites W2013812391 @default.
• W2799691218 cites W2035158854 @default.
• W2799691218 cites W2037398085 @default.
• W2799691218 cites W2047522959 @default.
• W2799691218 cites W2051072397 @default.
• W2799691218 cites W2061878956 @default.
• W2799691218 cites W2070300719 @default.
• W2799691218 cites W2073824449 @default.
• W2799691218 cites W2082580562 @default.
• W2799691218 cites W2084978938 @default.
• W2799691218 cites W2092348049 @default.
• W2799691218 cites W2096843137 @default.
• W2799691218 cites W2102072080 @default.
• W2799691218 cites W2103012009 @default.
• W2799691218 cites W2103023806 @default.
• W2799691218 cites W2109815623 @default.
• W2799691218 cites W2128547781 @default.
• W2799691218 cites W214459677 @default.
• W2799691218 cites W2147594030 @default.
• W2799691218 cites W2154250846 @default.
• W2799691218 cites W2158700877 @default.
• W2799691218 cites W2161018171 @default.
• W2799691218 cites W2168898577 @default.
• W2799691218 cites W2296941757 @default.
• W2799691218 cites W2333402398 @default.
• W2799691218 cites W2742279925 @default.
• W2799691218 cites W2755569089 @default.
• W2799691218 cites W2772511004 @default.
• W2799691218 cites W2781995184 @default.
• W2799691218 cites W4250024072 @default.
• W2799691218 cites W47390269 @default.
• W2799691218 doi "https://doi.org/10.1016/j.xphs.2018.04.015" @default.
• W2799691218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29698726" @default.
• W2799691218 hasPublicationYear "2018" @default.
• W2799691218 type Work @default.
• W2799691218 sameAs 2799691218 @default.
• W2799691218 citedByCount "2" @default.
• W2799691218 countsByYear W27996912182019 @default.
• W2799691218 countsByYear W27996912182022 @default.
• W2799691218 crossrefType "journal-article" @default.
• W2799691218 hasAuthorship W2799691218A5004480578 @default.
• W2799691218 hasAuthorship W2799691218A5023590664 @default.
• W2799691218 hasAuthorship W2799691218A5026110433 @default.
• W2799691218 hasAuthorship W2799691218A5034503760 @default.
• W2799691218 hasConcept C13965031 @default.
• W2799691218 hasConcept C147789679 @default.
• W2799691218 hasConcept C178790620 @default.
• W2799691218 hasConcept C185592680 @default.
• W2799691218 hasConcept C187530423 @default.
• W2799691218 hasConcept C202751555 @default.
• W2799691218 hasConcept C2777637488 @default.
• W2799691218 hasConcept C2778974779 @default.
• W2799691218 hasConcept C31903555 @default.
• W2799691218 hasConcept C4937899 @default.
• W2799691218 hasConcept C523546767 @default.
• W2799691218 hasConcept C54355233 @default.
• W2799691218 hasConcept C55493867 @default.
• W2799691218 hasConcept C58123911 @default.
• W2799691218 hasConcept C86803240 @default.
• W2799691218 hasConcept C89423630 @default.
• W2799691218 hasConceptScore W2799691218C13965031 @default.
• W2799691218 hasConceptScore W2799691218C147789679 @default.
• W2799691218 hasConceptScore W2799691218C178790620 @default.
• W2799691218 hasConceptScore W2799691218C185592680 @default.
• W2799691218 hasConceptScore W2799691218C187530423 @default.
• W2799691218 hasConceptScore W2799691218C202751555 @default.
• W2799691218 hasConceptScore W2799691218C2777637488 @default.
• W2799691218 hasConceptScore W2799691218C2778974779 @default.
• W2799691218 hasConceptScore W2799691218C31903555 @default.
• W2799691218 hasConceptScore W2799691218C4937899 @default.
• W2799691218 hasConceptScore W2799691218C523546767 @default.
• W2799691218 hasConceptScore W2799691218C54355233 @default.
• W2799691218 hasConceptScore W2799691218C55493867 @default.
• W2799691218 hasConceptScore W2799691218C58123911 @default.
• W2799691218 hasConceptScore W2799691218C86803240 @default.
• W2799691218 hasConceptScore W2799691218C89423630 @default.
• W2799691218 hasIssue "8" @default.
• W2799691218 hasLocation W27996912181 @default.
• W2799691218 hasLocation W27996912182 @default.
• W2799691218 hasOpenAccess W2799691218 @default.
• W2799691218 hasPrimaryLocation W27996912181 @default.

• next