FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799692595> ?p ?o ?g. }

• W2799692595 endingPage "464" @default.
• W2799692595 startingPage "453" @default.
• W2799692595 abstract "Constipation has a significant influence on quality of life. Patients with constipation have slow waves in their gastrointestinal smooth muscles and less faecal water contents, which are closely associated with down-regulation of the interstitial cells of Cajal (ICC) in the gastrointestinal muscles and the aquaporin protein AQP3 expressed in colon epithelial cells. Recent studies supported that patients with constipation have altered intestinal microbial structures compared with healthy controls. Intestinal dysbiosis might be one possible pathophysiological mechanism causing constipation. Bacterial strains, such as Lactobacillus spp., have shown many beneficial effects on the amelioration of constipation. However, few studies reported the structural changes of intestinal microbiota post-intervention of probiotics. In this study, a bacterial mixture was administrated to rats with loperamide-induced constipation. Effects of the bacterial mixture on small intestine transit (SIT), faecal water content, and the intestinal microbiome in rats were evaluated. Meanwhile, we investigated several factors involved in signalling pathways that regulate function of ICC and expression of AQP3 to discuss the possible underlying molecular mechanisms. Intervention of the bacterial mixture improved SIT and faecal water content in constipated rats. The up-regulation of C-kit/SP signalling pathways in ICC and AQP3 significantly contributed to improvements. These changes were closely associated with the manipulation of intestinal dysbiosis in constipated rats. Furthermore, our results revealed the important role of intestinal microbiota in affecting gut motility through regulation of serotonin biosynthesis. This monoamine neurotransmitter, secreted from enterochromaffin cells, up-regulated both substance P/neurokinin 1 receptors pathway of ICC and the expression of AQP3 in intestinal epithelial cells. Our study suggested that the disrupted microbiome in patients could be a potential therapeutic target for the improvement of constipation." @default.
• W2799692595 created "2018-05-17" @default.
• W2799692595 creator A5009590736 @default.
• W2799692595 creator A5009776918 @default.
• W2799692595 creator A5010449536 @default.
• W2799692595 creator A5010822994 @default.
• W2799692595 creator A5044734841 @default.
• W2799692595 creator A5048670764 @default.
• W2799692595 creator A5055849718 @default.
• W2799692595 creator A5063783789 @default.
• W2799692595 creator A5067742529 @default.
• W2799692595 date "2018-04-25" @default.
• W2799692595 modified "2023-10-13" @default.
• W2799692595 title "Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats" @default.
• W2799692595 cites W1494195458 @default.
• W2799692595 cites W1988321768 @default.
• W2799692595 cites W1991175004 @default.
• W2799692595 cites W1994914640 @default.
• W2799692595 cites W1997608252 @default.
• W2799692595 cites W2004877429 @default.
• W2799692595 cites W2014303640 @default.
• W2799692595 cites W2017708435 @default.
• W2799692595 cites W2018118692 @default.
• W2799692595 cites W2033386838 @default.
• W2799692595 cites W2039535498 @default.
• W2799692595 cites W2053176597 @default.
• W2799692595 cites W2056614650 @default.
• W2799692595 cites W2071886628 @default.
• W2799692595 cites W2072472496 @default.
• W2799692595 cites W2073837934 @default.
• W2799692595 cites W2075157391 @default.
• W2799692595 cites W2078272272 @default.
• W2799692595 cites W2084961602 @default.
• W2799692595 cites W2090687978 @default.
• W2799692595 cites W2114295370 @default.
• W2799692595 cites W2139327060 @default.
• W2799692595 cites W2141125135 @default.
• W2799692595 cites W2147726663 @default.
• W2799692595 cites W2163280886 @default.
• W2799692595 cites W2267018289 @default.
• W2799692595 cites W2276420866 @default.
• W2799692595 cites W2317433038 @default.
• W2799692595 cites W2344929874 @default.
• W2799692595 cites W2468315138 @default.
• W2799692595 cites W2510249233 @default.
• W2799692595 cites W2528304141 @default.
• W2799692595 cites W2561402640 @default.
• W2799692595 cites W2562921532 @default.
• W2799692595 cites W2575984858 @default.
• W2799692595 cites W2589387961 @default.
• W2799692595 cites W2593696574 @default.
• W2799692595 doi "https://doi.org/10.3920/bm2017.0062" @default.
• W2799692595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29633634" @default.
• W2799692595 hasPublicationYear "2018" @default.
• W2799692595 type Work @default.
• W2799692595 sameAs 2799692595 @default.
• W2799692595 citedByCount "25" @default.
• W2799692595 countsByYear W27996925952019 @default.
• W2799692595 countsByYear W27996925952020 @default.
• W2799692595 countsByYear W27996925952021 @default.
• W2799692595 countsByYear W27996925952022 @default.
• W2799692595 countsByYear W27996925952023 @default.
• W2799692595 crossrefType "journal-article" @default.
• W2799692595 hasAuthorship W2799692595A5009590736 @default.
• W2799692595 hasAuthorship W2799692595A5009776918 @default.
• W2799692595 hasAuthorship W2799692595A5010449536 @default.
• W2799692595 hasAuthorship W2799692595A5010822994 @default.
• W2799692595 hasAuthorship W2799692595A5044734841 @default.
• W2799692595 hasAuthorship W2799692595A5048670764 @default.
• W2799692595 hasAuthorship W2799692595A5055849718 @default.
• W2799692595 hasAuthorship W2799692595A5063783789 @default.
• W2799692595 hasAuthorship W2799692595A5067742529 @default.
• W2799692595 hasBestOaLocation W27996925951 @default.
• W2799692595 hasConcept C126322002 @default.
• W2799692595 hasConcept C140737988 @default.
• W2799692595 hasConcept C154280991 @default.
• W2799692595 hasConcept C201539569 @default.
• W2799692595 hasConcept C203014093 @default.
• W2799692595 hasConcept C204232928 @default.
• W2799692595 hasConcept C2776956441 @default.
• W2799692595 hasConcept C2777165150 @default.
• W2799692595 hasConcept C2778271842 @default.
• W2799692595 hasConcept C2779802037 @default.
• W2799692595 hasConcept C2781112942 @default.
• W2799692595 hasConcept C42407357 @default.
• W2799692595 hasConcept C539455810 @default.
• W2799692595 hasConcept C58207958 @default.
• W2799692595 hasConcept C71924100 @default.
• W2799692595 hasConcept C86803240 @default.
• W2799692595 hasConcept C95444343 @default.
• W2799692595 hasConceptScore W2799692595C126322002 @default.
• W2799692595 hasConceptScore W2799692595C140737988 @default.
• W2799692595 hasConceptScore W2799692595C154280991 @default.
• W2799692595 hasConceptScore W2799692595C201539569 @default.
• W2799692595 hasConceptScore W2799692595C203014093 @default.
• W2799692595 hasConceptScore W2799692595C204232928 @default.
• W2799692595 hasConceptScore W2799692595C2776956441 @default.
• W2799692595 hasConceptScore W2799692595C2777165150 @default.

• next