FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799699299> ?p ?o ?g. }

• W2799699299 endingPage "123" @default.
• W2799699299 startingPage "113" @default.
• W2799699299 abstract "In this work we use complex network theory to provide a statistical model of the connectivity patterns of human proteins and their interaction partners. Our intention is to identify important proteins that may be predisposed to be potential candidates as drug targets for therapeutic interventions. Target proteins usually have more interaction partners than non-target proteins, but there are no hard-and-fast rules for defining the actual number of interactions. We devise a statistical measure for identifying hub proteins, we score our target proteins with gene ontology annotations. The important druggable protein targets are likely to have similar biological functions that can be assessed for their potential therapeutic value. Our system provides a statistical analysis of the local and distant neighborhood protein interactions of the potential targets using complex network measures. This approach builds a more accurate model of drug-to-target activity and therefore the likely impact on treating diseases. We integrate high quality protein interaction data from the HINT database and disease associated proteins from the DrugTarget database. Other sources include biological knowledge from Gene Ontology and drug information from DrugBank. The problem is a very challenging one since the data is highly imbalanced between target proteins and the more numerous nontargets. We use undersampling on the training data and build Random Forest classifier models which are used to identify previously unclassified target proteins. We validate and corroborate these findings from the available literature." @default.
• W2799699299 created "2018-05-17" @default.
• W2799699299 creator A5002900117 @default.
• W2799699299 creator A5043895185 @default.
• W2799699299 date "2018-06-01" @default.
• W2799699299 modified "2023-10-17" @default.
• W2799699299 title "Complex network theory for the identification and assessment of candidate protein targets" @default.
• W2799699299 cites W1611787727 @default.
• W2799699299 cites W1968682237 @default.
• W2799699299 cites W1981637710 @default.
• W2799699299 cites W2009405916 @default.
• W2799699299 cites W2010707723 @default.
• W2799699299 cites W2011138994 @default.
• W2799699299 cites W2056782561 @default.
• W2799699299 cites W2056944867 @default.
• W2799699299 cites W2060748206 @default.
• W2799699299 cites W2062533676 @default.
• W2799699299 cites W2076117441 @default.
• W2799699299 cites W2081837827 @default.
• W2799699299 cites W2103017472 @default.
• W2799699299 cites W2110553827 @default.
• W2799699299 cites W2132820240 @default.
• W2799699299 cites W2138745145 @default.
• W2799699299 cites W2140883620 @default.
• W2799699299 cites W2153838454 @default.
• W2799699299 cites W2163480486 @default.
• W2799699299 cites W2171403830 @default.
• W2799699299 cites W2338910273 @default.
• W2799699299 cites W2346950316 @default.
• W2799699299 cites W2539985226 @default.
• W2799699299 cites W2911964244 @default.
• W2799699299 doi "https://doi.org/10.1016/j.compbiomed.2018.04.015" @default.
• W2799699299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29715596" @default.
• W2799699299 hasPublicationYear "2018" @default.
• W2799699299 type Work @default.
• W2799699299 sameAs 2799699299 @default.
• W2799699299 citedByCount "5" @default.
• W2799699299 countsByYear W27996992992018 @default.
• W2799699299 countsByYear W27996992992020 @default.
• W2799699299 countsByYear W27996992992021 @default.
• W2799699299 countsByYear W27996992992023 @default.
• W2799699299 crossrefType "journal-article" @default.
• W2799699299 hasAuthorship W2799699299A5002900117 @default.
• W2799699299 hasAuthorship W2799699299A5043895185 @default.
• W2799699299 hasBestOaLocation W27996992992 @default.
• W2799699299 hasConcept C104317684 @default.
• W2799699299 hasConcept C10679952 @default.
• W2799699299 hasConcept C111472728 @default.
• W2799699299 hasConcept C116834253 @default.
• W2799699299 hasConcept C11804247 @default.
• W2799699299 hasConcept C119857082 @default.
• W2799699299 hasConcept C124101348 @default.
• W2799699299 hasConcept C136536468 @default.
• W2799699299 hasConcept C138885662 @default.
• W2799699299 hasConcept C150194340 @default.
• W2799699299 hasConcept C154945302 @default.
• W2799699299 hasConcept C155261790 @default.
• W2799699299 hasConcept C169258074 @default.
• W2799699299 hasConcept C201797286 @default.
• W2799699299 hasConcept C25810664 @default.
• W2799699299 hasConcept C2780035454 @default.
• W2799699299 hasConcept C2987395477 @default.
• W2799699299 hasConcept C2989108626 @default.
• W2799699299 hasConcept C41008148 @default.
• W2799699299 hasConcept C54355233 @default.
• W2799699299 hasConcept C55105296 @default.
• W2799699299 hasConcept C55493867 @default.
• W2799699299 hasConcept C59822182 @default.
• W2799699299 hasConcept C60644358 @default.
• W2799699299 hasConcept C70721500 @default.
• W2799699299 hasConcept C74187038 @default.
• W2799699299 hasConcept C86803240 @default.
• W2799699299 hasConcept C95623464 @default.
• W2799699299 hasConcept C98274493 @default.
• W2799699299 hasConceptScore W2799699299C104317684 @default.
• W2799699299 hasConceptScore W2799699299C10679952 @default.
• W2799699299 hasConceptScore W2799699299C111472728 @default.
• W2799699299 hasConceptScore W2799699299C116834253 @default.
• W2799699299 hasConceptScore W2799699299C11804247 @default.
• W2799699299 hasConceptScore W2799699299C119857082 @default.
• W2799699299 hasConceptScore W2799699299C124101348 @default.
• W2799699299 hasConceptScore W2799699299C136536468 @default.
• W2799699299 hasConceptScore W2799699299C138885662 @default.
• W2799699299 hasConceptScore W2799699299C150194340 @default.
• W2799699299 hasConceptScore W2799699299C154945302 @default.
• W2799699299 hasConceptScore W2799699299C155261790 @default.
• W2799699299 hasConceptScore W2799699299C169258074 @default.
• W2799699299 hasConceptScore W2799699299C201797286 @default.
• W2799699299 hasConceptScore W2799699299C25810664 @default.
• W2799699299 hasConceptScore W2799699299C2780035454 @default.
• W2799699299 hasConceptScore W2799699299C2987395477 @default.
• W2799699299 hasConceptScore W2799699299C2989108626 @default.
• W2799699299 hasConceptScore W2799699299C41008148 @default.
• W2799699299 hasConceptScore W2799699299C54355233 @default.
• W2799699299 hasConceptScore W2799699299C55105296 @default.
• W2799699299 hasConceptScore W2799699299C55493867 @default.
• W2799699299 hasConceptScore W2799699299C59822182 @default.
• W2799699299 hasConceptScore W2799699299C60644358 @default.

• next