FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799741346> ?p ?o ?g. }

• W2799741346 endingPage "1548" @default.
• W2799741346 startingPage "1536" @default.
• W2799741346 abstract "Cytotoxic CD8+ T (Tc) cells are the main executors of transformed and cancer cells during cancer immunotherapy. The latest clinical results evidence a high efficacy of novel immunotherapy agents that modulate Tc cell activity against bad prognosis cancers. However, it has not been determined yet whether the efficacy of these treatments can be affected by selection of tumoural cells with mutations in the cell death machinery, known to promote drug resistance and cancer recurrence. Here, using a model of prophylactic tumour vaccination based on the LCMV-gp33 antigen and the mouse EL4 T lymphoma, we analysed the molecular mechanism employed by Tc cells to eliminate cancer cells in vivo and the impact of mutations in the apoptotic machinery on tumour development. First of all, we found that Tc cells, and perf and gzmB are required to efficiently eliminate EL4.gp33 cells after LCMV immunisation during short-term assays (1–4 h), and to prevent tumour development in the long term. Furthermore, we show that antigen-pulsed chemoresistant EL4 cells overexpressing Bcl-XL or a dominant negative form of caspase-3 are specifically eliminated from the peritoneum of infected animals, as fast as parental EL4 cells. Notably, antigen-specific Tc cells control the tumour growth of the mutated cells, as efficiently as in the case of parental cells. Altogether, expression of the anti-apoptotic mutations does not confer any advantage for tumour cells neither in the short-term survival nor in long-term tumour formation. Although the mechanism involved in the elimination of the apoptosis-resistant tumour cells is not completely elucidated, neither necroptosis nor pyroptosis seem to be involved. Our results provide the first experimental proof that chemoresistant cancer cells with mutations in the main cell death pathways are efficiently eliminated by Ag-specific Tc cells in vivo during immunotherapy and, thus, provide the molecular basis to treat chemoresistant cancer cells with CD8 Tc-based immunotherapy." @default.
• W2799741346 created "2018-05-17" @default.
• W2799741346 creator A5014822807 @default.
• W2799741346 creator A5039945339 @default.
• W2799741346 creator A5049957835 @default.
• W2799741346 creator A5066621566 @default.
• W2799741346 creator A5075010361 @default.
• W2799741346 creator A5082803813 @default.
• W2799741346 creator A5084453168 @default.
• W2799741346 creator A5087974339 @default.
• W2799741346 creator A5091302900 @default.
• W2799741346 date "2018-05-09" @default.
• W2799741346 modified "2023-10-17" @default.
• W2799741346 title "Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance" @default.
• W2799741346 cites W1516464304 @default.
• W2799741346 cites W1564196191 @default.
• W2799741346 cites W1580205301 @default.
• W2799741346 cites W1594353637 @default.
• W2799741346 cites W1786251417 @default.
• W2799741346 cites W1825962579 @default.
• W2799741346 cites W1896688767 @default.
• W2799741346 cites W1961486822 @default.
• W2799741346 cites W1968807800 @default.
• W2799741346 cites W1970509033 @default.
• W2799741346 cites W1971791973 @default.
• W2799741346 cites W1981039447 @default.
• W2799741346 cites W1986835835 @default.
• W2799741346 cites W1990757940 @default.
• W2799741346 cites W1992776047 @default.
• W2799741346 cites W1995275059 @default.
• W2799741346 cites W2009824727 @default.
• W2799741346 cites W2011945701 @default.
• W2799741346 cites W2012267998 @default.
• W2799741346 cites W2014075950 @default.
• W2799741346 cites W2022956052 @default.
• W2799741346 cites W2023075010 @default.
• W2799741346 cites W2026168152 @default.
• W2799741346 cites W2026391442 @default.
• W2799741346 cites W2034294546 @default.
• W2799741346 cites W2042010971 @default.
• W2799741346 cites W2047394489 @default.
• W2799741346 cites W2052947726 @default.
• W2799741346 cites W2061663136 @default.
• W2799741346 cites W2066671159 @default.
• W2799741346 cites W2074545819 @default.
• W2799741346 cites W2083514542 @default.
• W2799741346 cites W2085188839 @default.
• W2799741346 cites W2086851270 @default.
• W2799741346 cites W2093485788 @default.
• W2799741346 cites W2094726531 @default.
• W2799741346 cites W2098609440 @default.
• W2799741346 cites W2098940019 @default.
• W2799741346 cites W2102504033 @default.
• W2799741346 cites W2103699489 @default.
• W2799741346 cites W2105594055 @default.
• W2799741346 cites W2108767527 @default.
• W2799741346 cites W2114948357 @default.
• W2799741346 cites W2115697154 @default.
• W2799741346 cites W2115771186 @default.
• W2799741346 cites W2119502441 @default.
• W2799741346 cites W2121959762 @default.
• W2799741346 cites W2126072190 @default.
• W2799741346 cites W2128506942 @default.
• W2799741346 cites W2133158931 @default.
• W2799741346 cites W2153180469 @default.
• W2799741346 cites W2158662692 @default.
• W2799741346 cites W2161517578 @default.
• W2799741346 cites W2164284035 @default.
• W2799741346 cites W2177971463 @default.
• W2799741346 cites W2263759961 @default.
• W2799741346 cites W2331621923 @default.
• W2799741346 cites W2517129308 @default.
• W2799741346 cites W2518538521 @default.
• W2799741346 cites W2542459044 @default.
• W2799741346 cites W2563204578 @default.
• W2799741346 cites W2589053983 @default.
• W2799741346 cites W2607485471 @default.
• W2799741346 cites W2608165987 @default.
• W2799741346 doi "https://doi.org/10.1038/s41418-018-0112-9" @default.
• W2799741346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143514" @default.
• W2799741346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29743559" @default.
• W2799741346 hasPublicationYear "2018" @default.
• W2799741346 type Work @default.
• W2799741346 sameAs 2799741346 @default.
• W2799741346 citedByCount "16" @default.
• W2799741346 countsByYear W27997413462019 @default.
• W2799741346 countsByYear W27997413462020 @default.
• W2799741346 countsByYear W27997413462021 @default.
• W2799741346 countsByYear W27997413462022 @default.
• W2799741346 countsByYear W27997413462023 @default.
• W2799741346 crossrefType "journal-article" @default.
• W2799741346 hasAuthorship W2799741346A5014822807 @default.
• W2799741346 hasAuthorship W2799741346A5039945339 @default.
• W2799741346 hasAuthorship W2799741346A5049957835 @default.
• W2799741346 hasAuthorship W2799741346A5066621566 @default.
• W2799741346 hasAuthorship W2799741346A5075010361 @default.
• W2799741346 hasAuthorship W2799741346A5082803813 @default.
• W2799741346 hasAuthorship W2799741346A5084453168 @default.

• next