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• W2799747446 startingPage "561" @default.
• W2799747446 abstract "Publications from clinical trials of vitamin D supplementation have increased substantially over the last 15 years. Yet, despite the growing number of randomized controlled trials, meta-analyses of these studies have drawn inconsistent conclusions. Many meta-analyses assume that vitamin D is a pharmacological agent, and give scant consideration of it being a nutrient. This limits their potential to detect beneficial effects in participants with vitamin D deficiency. An increasing body of evidence from both observational studies and clinical trials supports the presence of thresholds in vitamin D status below which disease risk increases and vitamin supplementation has beneficial effects. Future supplementation trials which seek to replicate these findings should recruit sufficient numbers of participants with low vitamin D levels, and not give low-dose vitamin D to the placebo group. If the presence of vitamin D thresholds for beneficial effects is confirmed, this would strengthen the need for vitamin D fortification of foods." @default.
• W2799747446 created "2018-05-17" @default.
• W2799747446 creator A5043043565 @default.
• W2799747446 date "2018-05-03" @default.
• W2799747446 modified "2023-10-17" @default.
• W2799747446 title "Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation" @default.
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• W2799747446 doi "https://doi.org/10.3390/nu10050561" @default.
• W2799747446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5986441" @default.
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• W2799747446 hasPublicationYear "2018" @default.
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