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- W2799751389 abstract "目的研究fliD基因对空肠弯曲菌生物学特性的影响，为阐明该基因的功能和作用机制奠定基础。 方法利用同源重组技术构建fliD基因的插入失活突变株NCTC11168△fliD，并通过与野生株比较，对fliD突变株生长速率、运动力、黏附力和侵袭力等生物学特性进行研究。 结果与野生型NCTC11168相比，突变株NCTC11168△fliD的生理生化特性不变；突变株的生长速率无明显变化；MH半固体穿刺实验中，突变株只能在接种处生长，运动力明显减弱；在Caco-2细胞黏附、侵袭实验中，fliD突变株的黏附率和侵袭率分别为164.00±19.49、55.00±6.09，fliD基因失活使得突变株的黏附率和侵袭率显著降低（0＜P ＜ 0.01）。 结论fliD基因是空肠弯曲菌运动能力重要的分子基础，与空肠弯曲菌感染细胞的黏附侵袭作用密切相关，即与空肠弯曲菌的致病性密切相关。" @default.
- W2799751389 created "2018-05-17" @default.
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- W2799751389 date "2018-02-04" @default.
- W2799751389 modified "2023-10-18" @default.
- W2799751389 title "空肠弯曲菌 fliD 基因突变株的构建及其生物学特性" @default.
- W2799751389 doi "https://doi.org/10.13343/j.cnki.wsxb.20170095" @default.
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