Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799760112> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2799760112 abstract "In chicken, sex determination relies on a ZZ (male)/ZW (female) chromosomal system, but underlying mechanisms are still not fully understood. The Z-dosage and the dominant W-chromosome hypotheses have been proposed to underlie primary sex determination. We present a modelling approach, which assembles the current knowledge and permits exploring the regulation of this process in chicken. Relying on published experimental data, we assembled a gene network, which led to a logical model that integrates both the Z-dosage and dominant W hypotheses. This model showed that the sexual fate of chicken gonads results from the resolution of the mutual inhibition between DMRT1 and FOXL2, where the initial amount of DMRT1 product determines the development of the gonads. In this respect, at the initiation step, a W-factor would function as a secondary device, by reducing the amount of DMRT1 in ZW gonads when the sexual fate of the gonad is settled, that is when SOX9 functional level is established. Developmental constraints that are instrumental in this resolution were identified. These constraints establish qualitative restrictions regarding the relative transcription rates of the genes DMRT1, FOXL2 and HEMGN. Our model further clarified the role of OESTROGEN in maintaining FOXL2 function during ovary development." @default.
- W2799760112 created "2018-05-17" @default.
- W2799760112 creator A5015693980 @default.
- W2799760112 creator A5038231285 @default.
- W2799760112 date "2018-01-01" @default.
- W2799760112 modified "2023-09-23" @default.
- W2799760112 title "Supplementary material from Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads" @default.
- W2799760112 doi "https://doi.org/10.6084/m9.figshare.c.4094246.v1" @default.
- W2799760112 hasPublicationYear "2018" @default.
- W2799760112 type Work @default.
- W2799760112 sameAs 2799760112 @default.
- W2799760112 citedByCount "0" @default.
- W2799760112 crossrefType "journal-article" @default.
- W2799760112 hasAuthorship W2799760112A5015693980 @default.
- W2799760112 hasAuthorship W2799760112A5038231285 @default.
- W2799760112 hasConcept C104317684 @default.
- W2799760112 hasConcept C134018914 @default.
- W2799760112 hasConcept C137487509 @default.
- W2799760112 hasConcept C14036430 @default.
- W2799760112 hasConcept C2780246931 @default.
- W2799760112 hasConcept C2781037291 @default.
- W2799760112 hasConcept C2781471917 @default.
- W2799760112 hasConcept C54355233 @default.
- W2799760112 hasConcept C63405245 @default.
- W2799760112 hasConcept C70721500 @default.
- W2799760112 hasConcept C73456138 @default.
- W2799760112 hasConcept C86803240 @default.
- W2799760112 hasConceptScore W2799760112C104317684 @default.
- W2799760112 hasConceptScore W2799760112C134018914 @default.
- W2799760112 hasConceptScore W2799760112C137487509 @default.
- W2799760112 hasConceptScore W2799760112C14036430 @default.
- W2799760112 hasConceptScore W2799760112C2780246931 @default.
- W2799760112 hasConceptScore W2799760112C2781037291 @default.
- W2799760112 hasConceptScore W2799760112C2781471917 @default.
- W2799760112 hasConceptScore W2799760112C54355233 @default.
- W2799760112 hasConceptScore W2799760112C63405245 @default.
- W2799760112 hasConceptScore W2799760112C70721500 @default.
- W2799760112 hasConceptScore W2799760112C73456138 @default.
- W2799760112 hasConceptScore W2799760112C86803240 @default.
- W2799760112 hasLocation W27997601121 @default.
- W2799760112 hasOpenAccess W2799760112 @default.
- W2799760112 hasPrimaryLocation W27997601121 @default.
- W2799760112 hasRelatedWork W1605328609 @default.
- W2799760112 hasRelatedWork W1608145305 @default.
- W2799760112 hasRelatedWork W1859775981 @default.
- W2799760112 hasRelatedWork W1979997225 @default.
- W2799760112 hasRelatedWork W2036700061 @default.
- W2799760112 hasRelatedWork W2156107339 @default.
- W2799760112 hasRelatedWork W2360465926 @default.
- W2799760112 hasRelatedWork W2370547198 @default.
- W2799760112 hasRelatedWork W268657083 @default.
- W2799760112 hasRelatedWork W2768234140 @default.
- W2799760112 hasRelatedWork W27900853 @default.
- W2799760112 hasRelatedWork W2794651545 @default.
- W2799760112 hasRelatedWork W2804968966 @default.
- W2799760112 hasRelatedWork W2911431186 @default.
- W2799760112 hasRelatedWork W2925183325 @default.
- W2799760112 hasRelatedWork W3013296362 @default.
- W2799760112 hasRelatedWork W3198085288 @default.
- W2799760112 hasRelatedWork W3211987895 @default.
- W2799760112 hasRelatedWork W4352841 @default.
- W2799760112 hasRelatedWork W3083226427 @default.
- W2799760112 isParatext "false" @default.
- W2799760112 isRetracted "false" @default.
- W2799760112 magId "2799760112" @default.
- W2799760112 workType "article" @default.