Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799804903> ?p ?o ?g. }
- W2799804903 abstract "Abstract Aripiprazole’s effects on cognitive function in patients with schizophrenia are unclear because of the difficulty in disentangling specific effects on cognitive function from secondary effects due to the improvement in other schizophrenic symptoms. One approach to address this is to use an intermediate biomarker to investigate the relationship between the drug’s effect on the brain and change in cognitive function. This study aims to investigate aripiprazole’s effect on working memory by determining the correlation between dopamine D2/3 (D2/3) receptor occupancy and working memory of patients with schizophrenia. Seven patients with schizophrenia participated in the study. Serial positron emission tomography (PET) scans with [ 11 C]raclopride were conducted at 2, 26, and 74 h after the administration of aripiprazole. The subjects performed the N -back task just after finishing the [ 11 C]raclopride PET scan. The mean (±SD) D2/3 receptor occupancies were 66.9 ± 6.7% at 2 h, 65.0 ± 8.6% at 26, and 57.7 ± 11.2% at 74 h after administering aripiprazole. Compared with performance on the zero-back condition, performance in memory-loaded conditions (one-, two-, and three-back conditions) was significantly related to D2/3 receptor occupancy by aripiprazole (error rate: ß = −2.236, t = −6.631, df = 53.947, and p = 0.001; reaction time: ß = −9.567, t = −2.808, df = 29.967, and p = 0.009). Although the sample size was relatively small, these results suggest that aripiprazole as a dopamine-partial agonist could improve cognitive function in patients with schizophrenia." @default.
- W2799804903 created "2018-05-17" @default.
- W2799804903 creator A5000390635 @default.
- W2799804903 creator A5001601365 @default.
- W2799804903 creator A5008078906 @default.
- W2799804903 creator A5020102478 @default.
- W2799804903 creator A5027055033 @default.
- W2799804903 creator A5058145557 @default.
- W2799804903 creator A5079030694 @default.
- W2799804903 date "2018-04-24" @default.
- W2799804903 modified "2023-10-13" @default.
- W2799804903 title "The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [11C]-raclopride PET study with aripiprazole" @default.
- W2799804903 cites W1518890501 @default.
- W2799804903 cites W1934926274 @default.
- W2799804903 cites W1963544666 @default.
- W2799804903 cites W1964226700 @default.
- W2799804903 cites W1965819630 @default.
- W2799804903 cites W1969714399 @default.
- W2799804903 cites W1982819749 @default.
- W2799804903 cites W1988694821 @default.
- W2799804903 cites W1993693164 @default.
- W2799804903 cites W1993734032 @default.
- W2799804903 cites W1996065499 @default.
- W2799804903 cites W2004778445 @default.
- W2799804903 cites W2007980588 @default.
- W2799804903 cites W2010741426 @default.
- W2799804903 cites W2013333057 @default.
- W2799804903 cites W2026522842 @default.
- W2799804903 cites W2036918545 @default.
- W2799804903 cites W2038803089 @default.
- W2799804903 cites W2046680400 @default.
- W2799804903 cites W2050067518 @default.
- W2799804903 cites W2055033149 @default.
- W2799804903 cites W2059669521 @default.
- W2799804903 cites W2066640528 @default.
- W2799804903 cites W2070895158 @default.
- W2799804903 cites W2081308285 @default.
- W2799804903 cites W2087211525 @default.
- W2799804903 cites W2088022523 @default.
- W2799804903 cites W2088982413 @default.
- W2799804903 cites W2089895342 @default.
- W2799804903 cites W2099185967 @default.
- W2799804903 cites W2101948750 @default.
- W2799804903 cites W2107266956 @default.
- W2799804903 cites W2117671988 @default.
- W2799804903 cites W2117865454 @default.
- W2799804903 cites W2126364883 @default.
- W2799804903 cites W2145056060 @default.
- W2799804903 cites W2145619523 @default.
- W2799804903 cites W2154076395 @default.
- W2799804903 cites W2155554204 @default.
- W2799804903 cites W2162707091 @default.
- W2799804903 cites W2166759779 @default.
- W2799804903 cites W2281590068 @default.
- W2799804903 cites W2583981664 @default.
- W2799804903 cites W2642291021 @default.
- W2799804903 cites W58012858 @default.
- W2799804903 doi "https://doi.org/10.1038/s41398-018-0134-6" @default.
- W2799804903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5913226" @default.
- W2799804903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29686254" @default.
- W2799804903 hasPublicationYear "2018" @default.
- W2799804903 type Work @default.
- W2799804903 sameAs 2799804903 @default.
- W2799804903 citedByCount "20" @default.
- W2799804903 countsByYear W27998049032019 @default.
- W2799804903 countsByYear W27998049032020 @default.
- W2799804903 countsByYear W27998049032021 @default.
- W2799804903 countsByYear W27998049032022 @default.
- W2799804903 countsByYear W27998049032023 @default.
- W2799804903 crossrefType "journal-article" @default.
- W2799804903 hasAuthorship W2799804903A5000390635 @default.
- W2799804903 hasAuthorship W2799804903A5001601365 @default.
- W2799804903 hasAuthorship W2799804903A5008078906 @default.
- W2799804903 hasAuthorship W2799804903A5020102478 @default.
- W2799804903 hasAuthorship W2799804903A5027055033 @default.
- W2799804903 hasAuthorship W2799804903A5058145557 @default.
- W2799804903 hasAuthorship W2799804903A5079030694 @default.
- W2799804903 hasBestOaLocation W27998049031 @default.
- W2799804903 hasConcept C118552586 @default.
- W2799804903 hasConcept C126322002 @default.
- W2799804903 hasConcept C15744967 @default.
- W2799804903 hasConcept C169900460 @default.
- W2799804903 hasConcept C170493617 @default.
- W2799804903 hasConcept C21963081 @default.
- W2799804903 hasConcept C2776412080 @default.
- W2799804903 hasConcept C2778938600 @default.
- W2799804903 hasConcept C2780211496 @default.
- W2799804903 hasConcept C2781069445 @default.
- W2799804903 hasConcept C44208683 @default.
- W2799804903 hasConcept C513476851 @default.
- W2799804903 hasConcept C58732023 @default.
- W2799804903 hasConcept C71924100 @default.
- W2799804903 hasConceptScore W2799804903C118552586 @default.
- W2799804903 hasConceptScore W2799804903C126322002 @default.
- W2799804903 hasConceptScore W2799804903C15744967 @default.
- W2799804903 hasConceptScore W2799804903C169900460 @default.
- W2799804903 hasConceptScore W2799804903C170493617 @default.
- W2799804903 hasConceptScore W2799804903C21963081 @default.
- W2799804903 hasConceptScore W2799804903C2776412080 @default.
- W2799804903 hasConceptScore W2799804903C2778938600 @default.