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- W2799825394 abstract "Breast cancer is the leading cause of death in women. Prognosis of breast cancer is often pessimistic because the tumors are prone to metastasizing to the bone, brain, and lung. The estrogen signaling receptor (ESR) pathway contains 39 main genes and proteins which makes it one of the larger signaling pathways. Predominately this pathway and the proteins within are involved in breast growth and development, making it a prospective area of study for breast cancer. While the healthy ESR pathway has been constructed and is well established, a mechanistic model of mutated genes of ESR pathway has not been delved upon. Such mutated models could be utilized for selecting combinational targets for drug therapies, as well as elucidating crosstalk between other pathways and feedback mechanisms. To construct the mutated models of the ESR pathway it is imperative to assess what is currently understood in the literature and what inconsistencies exist in order to resolve them. Without this information, a model of the ESR pathway will be unreliable and likely unproductive. This review is the detailed literature survey of the biological studies performed on ESR pathways genes, and their respective roles in breast cancer. Furthermore, the details mentioned in the review can be beneficial for the integrated study of the ESR pathway genes, which includes, structural and dynamics study of the genes products, to have a holistic understanding of the cancer mechanism." @default.
- W2799825394 created "2018-05-17" @default.
- W2799825394 creator A5028246627 @default.
- W2799825394 creator A5040654056 @default.
- W2799825394 creator A5057073446 @default.
- W2799825394 creator A5086059519 @default.
- W2799825394 date "2018-01-01" @default.
- W2799825394 modified "2023-09-30" @default.
- W2799825394 title "Role of ESR Pathway Genes in Breast Cancer: A Review" @default.
- W2799825394 cites W1499388472 @default.
- W2799825394 cites W1505153529 @default.
- W2799825394 cites W1548456890 @default.
- W2799825394 cites W1548540209 @default.
- W2799825394 cites W1558393658 @default.
- W2799825394 cites W1595488035 @default.
- W2799825394 cites W1640008649 @default.
- W2799825394 cites W1814635547 @default.
- W2799825394 cites W1898471415 @default.
- W2799825394 cites W1933624549 @default.
- W2799825394 cites W1943317391 @default.
- W2799825394 cites W1966342316 @default.
- W2799825394 cites W1968524020 @default.
- W2799825394 cites W1969468802 @default.
- W2799825394 cites W1970473792 @default.
- W2799825394 cites W1971701977 @default.
- W2799825394 cites W1971793452 @default.
- W2799825394 cites W1972286336 @default.
- W2799825394 cites W1972578281 @default.
- W2799825394 cites W1973740519 @default.
- W2799825394 cites W1973924114 @default.
- W2799825394 cites W1973935686 @default.
- W2799825394 cites W1974740818 @default.
- W2799825394 cites W1977888948 @default.
- W2799825394 cites W1978490591 @default.
- W2799825394 cites W1979234986 @default.
- W2799825394 cites W1979385451 @default.
- W2799825394 cites W1980057938 @default.
- W2799825394 cites W1980194002 @default.
- W2799825394 cites W1981605516 @default.
- W2799825394 cites W1982057978 @default.
- W2799825394 cites W1983734334 @default.
- W2799825394 cites W1983953368 @default.
- W2799825394 cites W1987907341 @default.
- W2799825394 cites W1988336108 @default.
- W2799825394 cites W1989228312 @default.
- W2799825394 cites W1991174595 @default.
- W2799825394 cites W1991401350 @default.
- W2799825394 cites W1992175200 @default.
- W2799825394 cites W1992229434 @default.
- W2799825394 cites W1992358337 @default.
- W2799825394 cites W1994433492 @default.
- W2799825394 cites W1994451519 @default.
- W2799825394 cites W1994703138 @default.
- W2799825394 cites W1996280923 @default.
- W2799825394 cites W1997562938 @default.
- W2799825394 cites W1998872597 @default.
- W2799825394 cites W2000115025 @default.
- W2799825394 cites W2000453729 @default.
- W2799825394 cites W2000581759 @default.
- W2799825394 cites W2002550126 @default.
- W2799825394 cites W2002771508 @default.
- W2799825394 cites W2002984932 @default.
- W2799825394 cites W2003405179 @default.
- W2799825394 cites W2006628284 @default.
- W2799825394 cites W2007210021 @default.
- W2799825394 cites W2007437042 @default.
- W2799825394 cites W2009453033 @default.
- W2799825394 cites W2010475702 @default.
- W2799825394 cites W2012672176 @default.
- W2799825394 cites W2013672040 @default.
- W2799825394 cites W2015198866 @default.
- W2799825394 cites W2015308396 @default.
- W2799825394 cites W2015381890 @default.
- W2799825394 cites W2017611872 @default.
- W2799825394 cites W2017892333 @default.
- W2799825394 cites W2018893986 @default.
- W2799825394 cites W2022452401 @default.
- W2799825394 cites W2022489018 @default.
- W2799825394 cites W2023552087 @default.
- W2799825394 cites W2024256271 @default.
- W2799825394 cites W2024852746 @default.
- W2799825394 cites W2026362035 @default.
- W2799825394 cites W2026772419 @default.
- W2799825394 cites W2026842712 @default.
- W2799825394 cites W2027481178 @default.
- W2799825394 cites W2028389595 @default.
- W2799825394 cites W2028415754 @default.
- W2799825394 cites W2029881923 @default.
- W2799825394 cites W2031033821 @default.
- W2799825394 cites W2032665292 @default.
- W2799825394 cites W2032733509 @default.
- W2799825394 cites W2032840836 @default.
- W2799825394 cites W2033115234 @default.
- W2799825394 cites W2034649274 @default.
- W2799825394 cites W2035772234 @default.
- W2799825394 cites W2037603560 @default.
- W2799825394 cites W2038056767 @default.
- W2799825394 cites W2038434637 @default.