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• W2799861708 endingPage "1498" @default.
• W2799861708 startingPage "1485" @default.
• W2799861708 abstract "Abstract The extent of digestion of the complete diet is a major determinant of how well trace metal (elements) are absorbed by the gastrointestinal tract. Malabsorption tends to reduce trace metal uptake and absorption. Copper must be reduced to the cuprous ion (Cu+) prior to uptake mediated by the apically located CRT1 transporter. CRT1-mediated transport increases in dietary copper deficiency. Cu+ is transported across the trans-Golgi network by ATP7A. This transporter is also located at the basolateral membrane where an ATP-requiring mechanism pumps Cu+ into the plasma. ZIP4 is the major zinc transporter located at the apical membrane. Zip4 gene transcription increases in zinc deficiency and contributes to homeostatic upregulation of zinc transport at the apical surface. Zn2 + is transported into the trans-Golgi network by the transporter ZnT7 and/or could be bound to cytoplasmic binding proteins such as metallothionein. This protein acts as a metal buffer and the metallothionein gene is regulated by copper and zinc. Elevated synthesis of the protein may scavenge copper ions and limit copper availability for transport by ATP7A. Zinc associated with vesicles is transported from enterocytes by ZnT1 and perhaps other efflux transporters. Zinc transporter ZIP14 is believed to contribute to intestinal barrier function. Other ZIP and ZnT proteins may contribute to trafficking of zinc and other trace metals by enterocytes. Manganese absorption does not appear to require the metal transporter DMT1. Both hepatic ZIP14 and ZnT10 are necessary for effective secretion of manganese into the bile to prevent manganese accumulation by tissues. Selenocysteine and selenomethionine are well-absorbed sources of selenium and absorption occurs via various amino acid transporters, but without homeostatic regulation. Dietary deficiency of each of these trace metals has been shown to produce deficiency signs in humans and rodents. Defects in transport of zinc, copper, and manganese have been linked to specific medical disorders." @default.
• W2799861708 created "2018-05-17" @default.
• W2799861708 creator A5002485123 @default.
• W2799861708 creator A5042450354 @default.
• W2799861708 date "2018-01-01" @default.
• W2799861708 modified "2023-09-26" @default.
• W2799861708 title "Trace Metal Absorption and Transport" @default.
• W2799861708 cites W1528553045 @default.
• W2799861708 cites W1556599665 @default.
• W2799861708 cites W1568628619 @default.
• W2799861708 cites W1581558524 @default.
• W2799861708 cites W1583126230 @default.
• W2799861708 cites W1895744711 @default.
• W2799861708 cites W1965825383 @default.
• W2799861708 cites W1966397808 @default.
• W2799861708 cites W1967723307 @default.
• W2799861708 cites W1982937687 @default.
• W2799861708 cites W1983456088 @default.
• W2799861708 cites W1984540967 @default.
• W2799861708 cites W1987158454 @default.
• W2799861708 cites W1990103407 @default.
• W2799861708 cites W1992507434 @default.
• W2799861708 cites W1997268878 @default.
• W2799861708 cites W1998170972 @default.
• W2799861708 cites W1999169101 @default.
• W2799861708 cites W2002646870 @default.
• W2799861708 cites W2004385943 @default.
• W2799861708 cites W2005599373 @default.
• W2799861708 cites W2006138834 @default.
• W2799861708 cites W2009730483 @default.
• W2799861708 cites W2011360674 @default.
• W2799861708 cites W2011465631 @default.
• W2799861708 cites W2015092544 @default.
• W2799861708 cites W2024427829 @default.
• W2799861708 cites W2025086561 @default.
• W2799861708 cites W2027426905 @default.
• W2799861708 cites W2029298778 @default.
• W2799861708 cites W2029859548 @default.
• W2799861708 cites W2036910745 @default.
• W2799861708 cites W2039176236 @default.
• W2799861708 cites W2040396593 @default.
• W2799861708 cites W2042656746 @default.
• W2799861708 cites W2043286349 @default.
• W2799861708 cites W2046264231 @default.
• W2799861708 cites W2052912240 @default.
• W2799861708 cites W2053430176 @default.
• W2799861708 cites W2063667643 @default.
• W2799861708 cites W2074709818 @default.
• W2799861708 cites W2077129981 @default.
• W2799861708 cites W2079354362 @default.
• W2799861708 cites W2080526223 @default.
• W2799861708 cites W2081945079 @default.
• W2799861708 cites W2084492467 @default.
• W2799861708 cites W2084958079 @default.
• W2799861708 cites W2090003468 @default.
• W2799861708 cites W2094743639 @default.
• W2799861708 cites W2095150154 @default.
• W2799861708 cites W2095908732 @default.
• W2799861708 cites W2102090571 @default.
• W2799861708 cites W2103199749 @default.
• W2799861708 cites W2104852596 @default.
• W2799861708 cites W2107358262 @default.
• W2799861708 cites W2110710491 @default.
• W2799861708 cites W2110762028 @default.
• W2799861708 cites W2111712036 @default.
• W2799861708 cites W2112509605 @default.
• W2799861708 cites W2114870466 @default.
• W2799861708 cites W2117393206 @default.
• W2799861708 cites W2117821054 @default.
• W2799861708 cites W2125399293 @default.
• W2799861708 cites W2128206412 @default.
• W2799861708 cites W2129940110 @default.
• W2799861708 cites W2132471916 @default.
• W2799861708 cites W2134363913 @default.
• W2799861708 cites W2136748039 @default.
• W2799861708 cites W2144327256 @default.
• W2799861708 cites W2146578656 @default.
• W2799861708 cites W2147846966 @default.
• W2799861708 cites W2149498171 @default.
• W2799861708 cites W2155373017 @default.
• W2799861708 cites W2157045527 @default.
• W2799861708 cites W2158744241 @default.
• W2799861708 cites W2168596709 @default.
• W2799861708 cites W2177885379 @default.
• W2799861708 cites W2247851187 @default.
• W2799861708 cites W2337542123 @default.
• W2799861708 cites W2341849518 @default.
• W2799861708 cites W2346865476 @default.
• W2799861708 cites W2353139052 @default.
• W2799861708 cites W2373868424 @default.
• W2799861708 cites W2401922463 @default.
• W2799861708 cites W2407833081 @default.
• W2799861708 cites W2410056921 @default.
• W2799861708 cites W2418650982 @default.
• W2799861708 cites W2460851396 @default.
• W2799861708 cites W2525178139 @default.
• W2799861708 cites W2531184612 @default.
• W2799861708 cites W2620344049 @default.

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