FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2799956708> ?p ?o ?g. }

• W2799956708 endingPage "4485" @default.
• W2799956708 startingPage "4478" @default.
• W2799956708 abstract "Giant unilamellar vesicles (GUVs) provide a direct connection between the nano- and the microregime. On the one hand, these vesicles represent biomimetic compartments with linear dimensions of many micrometers. On the other hand, the vesicle walls are provided by single molecular bilayers that have a thickness of a few nanometers and respond sensitively to molecular interactions with small solutes, biopolymers, and nanoparticles. These nanoscopic responses are amplified by the GUVs and can then be studied on much larger scales. Therefore, GUVs are increasingly used as a versatile research tool for basic membrane science, bioengineering, and synthetic biology. Conventional GUVs have one major drawback, however: they have only a limited capability to cope with external perturbations such as osmotic inflation, adhesion, or micropipette aspiration that tend to rupture the membranes. In contrast, cell membranes tolerate the same kinds of mechanical perturbations without rupture because the latter membranes are coupled to reservoirs of membrane area. Here, we introduce GUVs with membrane nanotubes as model systems that include such area reservoirs. To demonstrate the increased robustness of these tubulated vesicles, we use micropipette aspiration and changes in the osmotic conditions applied to phospholipid membranes doped with the glycolipid GM1. A quantitative comparison between theory and experiment reveals that the response of the GUVs is governed by the membranes' spontaneous tension, a curvature-elastic material parameter that describes the bilayer asymmetry on the nanoscale. Because of their increased robustness, GUVs with nanotubes represent improved research tools for membrane science, in general, with potential applications as storage and delivery systems and as cell-like microcompartments in bioengineering, pharmacology, and synthetic biology." @default.
• W2799956708 created "2018-05-17" @default.
• W2799956708 creator A5023067075 @default.
• W2799956708 creator A5045589478 @default.
• W2799956708 creator A5071086704 @default.
• W2799956708 creator A5088026790 @default.
• W2799956708 date "2018-04-16" @default.
• W2799956708 modified "2023-10-12" @default.
• W2799956708 title "Membrane Nanotubes Increase the Robustness of Giant Vesicles" @default.
• W2799956708 cites W1618719257 @default.
• W2799956708 cites W1707637789 @default.
• W2799956708 cites W1896250904 @default.
• W2799956708 cites W1971518714 @default.
• W2799956708 cites W1976909705 @default.
• W2799956708 cites W1994215475 @default.
• W2799956708 cites W1995950736 @default.
• W2799956708 cites W2006689028 @default.
• W2799956708 cites W2013141559 @default.
• W2799956708 cites W2014405796 @default.
• W2799956708 cites W2022758871 @default.
• W2799956708 cites W2033406794 @default.
• W2799956708 cites W2035512416 @default.
• W2799956708 cites W2036223148 @default.
• W2799956708 cites W2037243669 @default.
• W2799956708 cites W2045678504 @default.
• W2799956708 cites W2046505197 @default.
• W2799956708 cites W2051953600 @default.
• W2799956708 cites W2080484884 @default.
• W2799956708 cites W2099196652 @default.
• W2799956708 cites W2110120485 @default.
• W2799956708 cites W2114919725 @default.
• W2799956708 cites W2130531386 @default.
• W2799956708 cites W2138035663 @default.
• W2799956708 cites W2138402450 @default.
• W2799956708 cites W2199875511 @default.
• W2799956708 cites W2211940871 @default.
• W2799956708 cites W2264936970 @default.
• W2799956708 cites W2297959802 @default.
• W2799956708 cites W2410960870 @default.
• W2799956708 cites W2508800480 @default.
• W2799956708 cites W2526579288 @default.
• W2799956708 cites W2535676950 @default.
• W2799956708 cites W2546465169 @default.
• W2799956708 cites W2552979639 @default.
• W2799956708 cites W2564657765 @default.
• W2799956708 cites W2564884000 @default.
• W2799956708 cites W2578682593 @default.
• W2799956708 cites W2587308453 @default.
• W2799956708 cites W2604697223 @default.
• W2799956708 cites W2614023144 @default.
• W2799956708 cites W2752285554 @default.
• W2799956708 cites W2766036492 @default.
• W2799956708 cites W4255561970 @default.
• W2799956708 doi "https://doi.org/10.1021/acsnano.8b00640" @default.
• W2799956708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29659246" @default.
• W2799956708 hasPublicationYear "2018" @default.
• W2799956708 type Work @default.
• W2799956708 sameAs 2799956708 @default.
• W2799956708 citedByCount "56" @default.
• W2799956708 countsByYear W27999567082018 @default.
• W2799956708 countsByYear W27999567082019 @default.
• W2799956708 countsByYear W27999567082020 @default.
• W2799956708 countsByYear W27999567082021 @default.
• W2799956708 countsByYear W27999567082022 @default.
• W2799956708 countsByYear W27999567082023 @default.
• W2799956708 crossrefType "journal-article" @default.
• W2799956708 hasAuthorship W2799956708A5023067075 @default.
• W2799956708 hasAuthorship W2799956708A5045589478 @default.
• W2799956708 hasAuthorship W2799956708A5071086704 @default.
• W2799956708 hasAuthorship W2799956708A5088026790 @default.
• W2799956708 hasBestOaLocation W27999567081 @default.
• W2799956708 hasConcept C12554922 @default.
• W2799956708 hasConcept C130316041 @default.
• W2799956708 hasConcept C15920480 @default.
• W2799956708 hasConcept C159985019 @default.
• W2799956708 hasConcept C171250308 @default.
• W2799956708 hasConcept C185592680 @default.
• W2799956708 hasConcept C192157962 @default.
• W2799956708 hasConcept C192562407 @default.
• W2799956708 hasConcept C2777278457 @default.
• W2799956708 hasConcept C39944091 @default.
• W2799956708 hasConcept C41625074 @default.
• W2799956708 hasConcept C45206210 @default.
• W2799956708 hasConcept C51115888 @default.
• W2799956708 hasConcept C521977710 @default.
• W2799956708 hasConcept C55493867 @default.
• W2799956708 hasConcept C67407626 @default.
• W2799956708 hasConcept C86803240 @default.
• W2799956708 hasConcept C96347405 @default.
• W2799956708 hasConceptScore W2799956708C12554922 @default.
• W2799956708 hasConceptScore W2799956708C130316041 @default.
• W2799956708 hasConceptScore W2799956708C15920480 @default.
• W2799956708 hasConceptScore W2799956708C159985019 @default.
• W2799956708 hasConceptScore W2799956708C171250308 @default.
• W2799956708 hasConceptScore W2799956708C185592680 @default.
• W2799956708 hasConceptScore W2799956708C192157962 @default.
• W2799956708 hasConceptScore W2799956708C192562407 @default.
• W2799956708 hasConceptScore W2799956708C2777278457 @default.

• next