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- W2799971805 abstract "Behçet disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions. Disease etiopathogenesis is still unclear. We aim to elucidate some aspects of BD pathogenesis and to identify specific gene signatures in peripheral blood cells (PBCs) of patients with active disease using novel gene expression and network analysis. 179 genes were modulated in 10 PBCs of BD patients when compared to 10 healthy donors. Among differentially expressed genes the top enriched gene function was immune response, characterized by upregulation of Th17-related genes and type I interferon- (IFN-) inducible genes. Th17 polarization was confirmed by FACS analysis. The transcriptome identified gene classes (vascular damage, blood coagulation, and inflammation) involved in the pathogenesis of the typical features of BD. Following network analysis, the resulting interactome showed 5 highly connected regions (clusters) enriched in T and B cell activation pathways and 2 clusters enriched in type I IFN, JAK/STAT, and TLR signaling pathways, all implicated in autoimmune diseases. We report here the first combined analysis of the transcriptome and interactome in PBCs of BD patients in the active stage of disease. This approach generates useful insights in disease pathogenesis and suggests an autoimmune component in the origin of BD." @default.
- W2799971805 created "2018-05-17" @default.
- W2799971805 creator A5001587408 @default.
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- W2799971805 date "2018-01-01" @default.
- W2799971805 modified "2023-10-14" @default.
- W2799971805 title "Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy" @default.
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- W2799971805 doi "https://doi.org/10.1155/2018/4246965" @default.
- W2799971805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5941805" @default.
- W2799971805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29850627" @default.
- W2799971805 hasPublicationYear "2018" @default.