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• W2800028653 abstract "MicroRNAs (miRNAs) are small noncoding 20–25 nt RNA molecules that regulate gene expression by posttranscriptional repression of messenger RNA. There have been few investigations on the profiles and functions of miRNAs in ovine subcutaneous fat; their roles in the metabolism and deposition of subcutaneous fat also remain unclear. In this study, small RNA libraries were constructed for 2 important Chinese local sheep breeds, Small-tailed Han Sheep, and Shanxi Meat Sheep Dam Line, and used for high-throughput sequencing. Differentially expressed miRNAs were identified, revealing the effect of miR-124-3p on adipogenic differentiation by targeting C/EBPα. Our results provide both a comprehensive understanding of miRNA expression patterns in sheep subcutaneous fat and an insight into the specific roles of miRNAs in adipogenesis." @default.
• W2800028653 created "2018-05-17" @default.
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• W2800028653 date "2018-10-01" @default.
• W2800028653 modified "2023-10-16" @default.
• W2800028653 title "MiRNA-seq reveals that miR-124-3p inhibits adipogenic differentiation of the stromal vascular fraction in sheep via targeting C/EBPα" @default.
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• W2800028653 doi "https://doi.org/10.1016/j.domaniend.2018.05.002" @default.
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