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• W2800045152 abstract "Background: Long non-coding RNAs (lncRNAs) Hox transcript antisense intergenic RNA ( HOTAIR) has been suggested to be implicated in gastric cancer tumorigenesis and progression; however, little is known about the role of the plasma HOTAIR in gastric cancer diagnosis and prognosis. Objective: The current study was aimed at investigating the clinical relevance of plasma long non-coding HOTAIR as a non-invasive diagnostic biomarker in gastric cancer. Methods: Plasma HOTAIR expression was measured in 50 patients with newly diagnosed gastric cancer and 50 age- and sex-matched healthy controls using quantitative reverse transcription polymerase chain reaction. Results: Plasma level of HOTAIR was significantly higher in gastric cancer patients compared with healthy controls ( P < 0.001). By using receiver operating characteristic curve analysis, it was found that plasma HOTAIR could diagnose gastric cancer with 88% sensitivity and 84% specificity. Furthermore, increased HOTAIR expression was associated with advanced tumor stages, higher grades, and metastasis. Conclusion: Plasma HOTAIR might serve as a potential non-invasive biomarker for diagnosis of gastric cancer." @default.
• W2800045152 created "2018-05-17" @default.
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• W2800045152 date "2018-04-23" @default.
• W2800045152 modified "2023-10-16" @default.
• W2800045152 title "Plasma long non-coding RNA <i>HOTAIR</i> as a potential biomarker for gastric cancer" @default.
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• W2800045152 doi "https://doi.org/10.1177/1724600818760244" @default.
• W2800045152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29683069" @default.
• W2800045152 hasPublicationYear "2018" @default.
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