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- W2800055480 endingPage "480" @default.
- W2800055480 startingPage "465" @default.
- W2800055480 abstract "Crimean-Congo haemorrhagic fever (CCHF) is a widespread tick-borne viral zoonosis with a case-fatality rate ranging from 9% to 50% in humans. Although a licensed vaccine to prevent infection by the CCHF virus (CCHFV) exists, its ability to induce neutralizing antibodies is limited and its efficacy against CCHFV remains undetermined. In addition, controlling CCHF infections by eradication of the tick reservoir has been ineffective, both economically and logistically, and the treatment options for CCHF remain limited. In this review, we first critically discuss the existing animal models to evaluate therapeutics for CCHF. We then review the therapeutic options for CCHF that have been investigated in human cases, followed by investigational drugs that have been evaluated in pre-clinical studies. We highlight the importance of understanding human prognostic factors in developing an animal model for CCHF that recapitulates hallmarks of human disease and its implication for selecting therapeutic candidates." @default.
- W2800055480 created "2018-05-17" @default.
- W2800055480 creator A5004180557 @default.
- W2800055480 creator A5007882592 @default.
- W2800055480 creator A5035647299 @default.
- W2800055480 creator A5052395699 @default.
- W2800055480 date "2018-04-20" @default.
- W2800055480 modified "2023-10-01" @default.
- W2800055480 title "Crimean-Congo haemorrhagic fever virus: Past, present and future insights for animal modelling and medical countermeasures" @default.
- W2800055480 cites W137460477 @default.
- W2800055480 cites W1494987922 @default.
- W2800055480 cites W1543288877 @default.
- W2800055480 cites W166428246 @default.
- W2800055480 cites W1664973405 @default.
- W2800055480 cites W1731650218 @default.
- W2800055480 cites W1902985844 @default.
- W2800055480 cites W1963510791 @default.
- W2800055480 cites W1963831150 @default.
- W2800055480 cites W1964461462 @default.
- W2800055480 cites W1973115801 @default.
- W2800055480 cites W1975556170 @default.
- W2800055480 cites W1976163862 @default.
- W2800055480 cites W1977070628 @default.
- W2800055480 cites W1988098374 @default.
- W2800055480 cites W1990830580 @default.
- W2800055480 cites W1993512576 @default.
- W2800055480 cites W1995345282 @default.
- W2800055480 cites W1995388272 @default.
- W2800055480 cites W1999772393 @default.
- W2800055480 cites W2010573899 @default.
- W2800055480 cites W2012873813 @default.
- W2800055480 cites W2019100213 @default.
- W2800055480 cites W2020202215 @default.
- W2800055480 cites W2022434050 @default.
- W2800055480 cites W2023520005 @default.
- W2800055480 cites W2026884435 @default.
- W2800055480 cites W2028514454 @default.
- W2800055480 cites W2029546039 @default.
- W2800055480 cites W2030140401 @default.
- W2800055480 cites W2030206448 @default.
- W2800055480 cites W2030805392 @default.
- W2800055480 cites W2031157782 @default.
- W2800055480 cites W2034600163 @default.
- W2800055480 cites W2035794617 @default.
- W2800055480 cites W2036307020 @default.
- W2800055480 cites W2043816723 @default.
- W2800055480 cites W2043950449 @default.
- W2800055480 cites W2046712365 @default.
- W2800055480 cites W2046859933 @default.
- W2800055480 cites W2047336000 @default.
- W2800055480 cites W2060514161 @default.
- W2800055480 cites W2060823949 @default.
- W2800055480 cites W2066699618 @default.
- W2800055480 cites W2089974427 @default.
- W2800055480 cites W2090061125 @default.
- W2800055480 cites W2092691555 @default.
- W2800055480 cites W2093188984 @default.
- W2800055480 cites W2097585744 @default.
- W2800055480 cites W2098574828 @default.
- W2800055480 cites W2100967823 @default.
- W2800055480 cites W2116774693 @default.
- W2800055480 cites W2118505327 @default.
- W2800055480 cites W2120581197 @default.
- W2800055480 cites W2120682265 @default.
- W2800055480 cites W2124894893 @default.
- W2800055480 cites W2125577345 @default.
- W2800055480 cites W2126440822 @default.
- W2800055480 cites W2127248475 @default.
- W2800055480 cites W2129184914 @default.
- W2800055480 cites W2129882416 @default.
- W2800055480 cites W2130104289 @default.
- W2800055480 cites W2134620724 @default.
- W2800055480 cites W2135903976 @default.
- W2800055480 cites W2136048242 @default.
- W2800055480 cites W2139603860 @default.
- W2800055480 cites W2145128241 @default.
- W2800055480 cites W2148802878 @default.
- W2800055480 cites W21510178 @default.
- W2800055480 cites W2151161022 @default.
- W2800055480 cites W2154802237 @default.
- W2800055480 cites W2155073164 @default.
- W2800055480 cites W2156347461 @default.
- W2800055480 cites W2158234806 @default.
- W2800055480 cites W2160584184 @default.
- W2800055480 cites W2165929860 @default.
- W2800055480 cites W2169354818 @default.
- W2800055480 cites W2173142588 @default.
- W2800055480 cites W2222375237 @default.
- W2800055480 cites W2237114532 @default.
- W2800055480 cites W2239889192 @default.
- W2800055480 cites W2258867806 @default.
- W2800055480 cites W2273102494 @default.
- W2800055480 cites W2274074424 @default.
- W2800055480 cites W2283562427 @default.
- W2800055480 cites W2283811383 @default.
- W2800055480 cites W2300145515 @default.
- W2800055480 cites W2319578681 @default.
- W2800055480 cites W2319815586 @default.