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- W2800056009 abstract "To characterize the pathophysiology associated with lentigo formation we performed gene expression profiling on six lentigos and control skin specimens that were matched for age and sex. Analysis of the comparative gene expression data using TAC 4.0 software using filters for fold changes 2 and P-Mal < 0.05 identified 861 transcripts that met these filter criteria. 605 genes were upregulated in lentigos with 577 coding and 28 non-coding transcripts. The most upregulated transcripts included: 1) COX6C - 37.6 fold, 2) PRKAR1A - 27.3 fold, 3) KLF10 - 16. 8 fold, 4) ELF2S3 - 14.2 fold. The top up-regulated non-coding transcripts included: 1) SNORA12 - 80.1 fold, 2) miR1244 - 55.7 fold, 3) SNORD70 - 50.4 fold, 4) miR4521 - 41.9 fold. 256 transcripts were down-regulated significantly and consisted of 184 coding and 72 non-coding transcripts. The most down-regulated coding transcripts included: 1) SPARC - 10.3 fold, lymphotoxin beta - 6.3 fold, 3) AQP1 - 5.4 fold changed, 4) LULC7L3 (LUC7-like 3 pre-mRNA splicing factor) - 5.1 fold. Downregulated non-coding transcripts included: 1) SNORD113-1 (small nucleolar RNA, C/D box 113-1) - 45.8 fold, 2) miR548W - 10.5 fold, 3) miR4454 - 9.3 fold, 4) miR548A-3 - 4.7 fold. PRKAR1A is the regulatory subunit of cAMP dependent protein kinase which regulates pigmentation signaling in melanocytes and is mutated in Carney complex, a lentiginosis syndrome. Overall, these data identify transcripts associated with lentigo formation that may represent therapeutic targets." @default.
- W2800056009 created "2018-05-17" @default.
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- W2800056009 date "2018-05-01" @default.
- W2800056009 modified "2023-10-18" @default.
- W2800056009 title "1261 Transcriptome profiling of lentigos identifies potential therapeutic targets" @default.
- W2800056009 doi "https://doi.org/10.1016/j.jid.2018.03.1276" @default.
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