Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800062830> ?p ?o ?g. }
- W2800062830 endingPage "487" @default.
- W2800062830 startingPage "474" @default.
- W2800062830 abstract "Despite the success of colonoscopy screening and recent advances in cancer treatment, colorectal cancer (CRC) still remains one of the most commonly diagnosed and deadly cancers, with a significantly increased incidence in developing countries where people are adapting to Western lifestyle. Diet has an important impact on risk of CRC. Multiple epidemiological studies have suggested that excessive animal protein and fat intake, especially red meat and processed meat, could increase the risk of developing CRC while fiber could protect against colorectal tumorigenesis. Mechanisms have been investigated by animal studies. Diet could re-shape the community structure of gut microbiota and influence its function by modulating the production of metabolites. Butyrate, one of the short-chain fatty acids (SCFAs), which act as a favorable source for colonocytes, could protect colonic epithelial cells from tumorigenesis via anti-inflammatory and antineoplastic properties through cell metabolism, microbiota homeostasis, antiproliferative, immunomodulatory and genetic/epigenetic regulation ways. In contrast, protein fermentation and bile acid deconjugation, which cause damage to colonic cells through proinflammatory and proneoplastic ways, lead to increased risk of developing CRC. In conclusion, a balanced diet with an increased abundance of fiber should be adopted to reduce the risk and prevent CRC." @default.
- W2800062830 created "2018-05-17" @default.
- W2800062830 creator A5007585753 @default.
- W2800062830 creator A5052046874 @default.
- W2800062830 date "2018-04-30" @default.
- W2800062830 modified "2023-10-10" @default.
- W2800062830 title "The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get" @default.
- W2800062830 cites W1503397342 @default.
- W2800062830 cites W1507385857 @default.
- W2800062830 cites W1578160884 @default.
- W2800062830 cites W1585365836 @default.
- W2800062830 cites W162561352 @default.
- W2800062830 cites W1862711637 @default.
- W2800062830 cites W1900164494 @default.
- W2800062830 cites W1901660111 @default.
- W2800062830 cites W1906888123 @default.
- W2800062830 cites W1907535411 @default.
- W2800062830 cites W1914472235 @default.
- W2800062830 cites W1934624334 @default.
- W2800062830 cites W1935534922 @default.
- W2800062830 cites W1953702613 @default.
- W2800062830 cites W1959271091 @default.
- W2800062830 cites W1964301321 @default.
- W2800062830 cites W1964692441 @default.
- W2800062830 cites W1967189039 @default.
- W2800062830 cites W1968321140 @default.
- W2800062830 cites W1968638594 @default.
- W2800062830 cites W1968852780 @default.
- W2800062830 cites W1969339002 @default.
- W2800062830 cites W1978204085 @default.
- W2800062830 cites W1980496573 @default.
- W2800062830 cites W1983775809 @default.
- W2800062830 cites W1984713132 @default.
- W2800062830 cites W1985515102 @default.
- W2800062830 cites W1987375206 @default.
- W2800062830 cites W1988813839 @default.
- W2800062830 cites W1989973079 @default.
- W2800062830 cites W1990436525 @default.
- W2800062830 cites W1993286285 @default.
- W2800062830 cites W1995509223 @default.
- W2800062830 cites W1995834499 @default.
- W2800062830 cites W1996455919 @default.
- W2800062830 cites W1998938534 @default.
- W2800062830 cites W1999163677 @default.
- W2800062830 cites W1999615507 @default.
- W2800062830 cites W1999913271 @default.
- W2800062830 cites W2000067794 @default.
- W2800062830 cites W2000442055 @default.
- W2800062830 cites W2001494923 @default.
- W2800062830 cites W2002222928 @default.
- W2800062830 cites W2003099302 @default.
- W2800062830 cites W2005338000 @default.
- W2800062830 cites W2006292369 @default.
- W2800062830 cites W2008583330 @default.
- W2800062830 cites W2008631743 @default.
- W2800062830 cites W2009601425 @default.
- W2800062830 cites W2012062618 @default.
- W2800062830 cites W2013680572 @default.
- W2800062830 cites W2023678020 @default.
- W2800062830 cites W2024404684 @default.
- W2800062830 cites W2024804350 @default.
- W2800062830 cites W2025613531 @default.
- W2800062830 cites W2026897048 @default.
- W2800062830 cites W2035342243 @default.
- W2800062830 cites W2038023605 @default.
- W2800062830 cites W2038217946 @default.
- W2800062830 cites W2039049958 @default.
- W2800062830 cites W2040120466 @default.
- W2800062830 cites W2040576508 @default.
- W2800062830 cites W2041202701 @default.
- W2800062830 cites W2041311742 @default.
- W2800062830 cites W2041816161 @default.
- W2800062830 cites W2042956045 @default.
- W2800062830 cites W2046172892 @default.
- W2800062830 cites W2049941261 @default.
- W2800062830 cites W2055985695 @default.
- W2800062830 cites W2056920355 @default.
- W2800062830 cites W2057041675 @default.
- W2800062830 cites W2063666894 @default.
- W2800062830 cites W2065476799 @default.
- W2800062830 cites W2070601333 @default.
- W2800062830 cites W2072090020 @default.
- W2800062830 cites W2075160088 @default.
- W2800062830 cites W2075787169 @default.
- W2800062830 cites W2075802734 @default.
- W2800062830 cites W2076620496 @default.
- W2800062830 cites W2077333801 @default.
- W2800062830 cites W2079401752 @default.
- W2800062830 cites W2079556277 @default.
- W2800062830 cites W2079809637 @default.
- W2800062830 cites W2080503858 @default.
- W2800062830 cites W2082480797 @default.
- W2800062830 cites W2086702544 @default.
- W2800062830 cites W2087292184 @default.
- W2800062830 cites W2088104687 @default.
- W2800062830 cites W2089088675 @default.
- W2800062830 cites W2089633816 @default.
- W2800062830 cites W2089643849 @default.