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• W2800103040 startingPage "1400" @default.
• W2800103040 abstract "Biological systems are endowed with two fundamental but seemingly contradictory properties: robustness, the ability to withstand environmental fluctuations and genetic variability; and evolvability, the ability to acquire selectable and heritable phenotypic changes. Cell populations with heterogeneous genetic makeup, such as those of infectious microbial organisms or cancer, rely on their inherent robustness to maintain viability and fitness, but when encountering environmental insults, such as drug treatment, these populations are also poised for rapid adaptation through evolutionary selection. In this study, we develop a general mathematical model that allows us to explain and quantify this fundamental relationship between robustness and evolvability of heterogeneous cell populations. Our model predicts that robustness is, in fact, essential for evolvability, especially for more adverse environments, a trend we observe in aneuploid budding yeast and breast cancer cells. Robustness also compensates for the negative impact of the systems’ complexity on their evolvability. Our model also provides a mathematical means to estimate the number of independent processes underlying a system’s performance and identify the most generally adapted subpopulation, which may resemble the multi-drug-resistant “persister” cells observed in cancer." @default.
• W2800103040 created "2018-05-17" @default.
• W2800103040 creator A5029003002 @default.
• W2800103040 creator A5031543598 @default.
• W2800103040 creator A5042275051 @default.
• W2800103040 creator A5067556590 @default.
• W2800103040 date "2018-06-01" @default.
• W2800103040 modified "2023-09-27" @default.
• W2800103040 title "Robustness and evolvability of heterogeneous cell populations" @default.
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• W2800103040 doi "https://doi.org/10.1091/mbc.e18-01-0070" @default.
• W2800103040 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5994894" @default.
• W2800103040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29851566" @default.
• W2800103040 hasPublicationYear "2018" @default.
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