FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800117622> ?p ?o ?g. }

• W2800117622 abstract "The severity of chronic chagasic cardiomyopathy (CCC), the most frequent clinical outcome of Chagas disease (CD), has been associated with cytokine-enriched heart tissue inflammation, and high serum levels of transforming growth factor (TGFβ), interferon-gamma (IFNγ), and tumour necrosis factor (TNF). Conversely, increased interleukin (IL)-10 serum concentrations have been associated with asymptomatic CD. Cytokines and cytokine-related gene polymorphisms may control cytokine expression and have been proposed to contribute to CCC outcomes.We evaluated the association of 13 cytokine-related genes (TGFB: rs8179181, rs8105161, rs1800469; IL10: rs1800890, rs1800871, rs1800896; IFNG: rs2430561; TNF: rs1800629; BAT1: rs3853601; LTA: rs909253, rs2239704; TNFR1: rs767455; TNFR2: rs1061624) with risk and progression of CCC.Four hundred and six seropositive patients from CD endemic areas in the state of Pernambuco, north-eastern Brazil, were classified as non-cardiopathic (A, 110) or cardiopathic (mild, B1, 163; severe, C, 133). We found no evidence of TGFB, IL10, TNF, or TNFR1/2 gene polymorphisms associated with CCC risk or progression. Only BAT1 rs3853601 -22G carriers (B1 vs. C: OR = 0.5; p-value = 0.03) and IFNG rs2430561 +874AT (A vs. C: OR = 0.7; p-value = 0.03; A vs. B1+C: OR = 0.8; p-value = 0.02) showed a significant association with protection from cardiopathy in a logistic regression analysis with adjustment for gender and ethnicity; however, the association disappeared after performing adjustment for multiple testing. A systematic review of TNF rs1800629 -308G>A publications included five studies for meta-analysis (534 CCC and 472 asymptomatic patients) and showed no consensus in pooled odds ratio (OR) estimates for A allele or A carriers (OR = 1.4 and 1.5; p-values = 0.14 and 0.15, respectively). In CD patients, TNF serum levels were increased, but not affected by the TNF rs1800629 -308A allele.Our data suggest no significant contribution of the analysed gene variants of cytokine-related molecules to development/severity of Chagas' heart disease, reinforcing the idea that parasite/host interplay is critical to CD outcomes." @default.
• W2800117622 created "2018-05-17" @default.
• W2800117622 creator A5001118043 @default.
• W2800117622 creator A5018954082 @default.
• W2800117622 creator A5020546900 @default.
• W2800117622 creator A5027126625 @default.
• W2800117622 creator A5037399431 @default.
• W2800117622 creator A5039645227 @default.
• W2800117622 creator A5072058550 @default.
• W2800117622 creator A5074369942 @default.
• W2800117622 creator A5075594976 @default.
• W2800117622 creator A5076343777 @default.
• W2800117622 creator A5086132806 @default.
• W2800117622 creator A5089054320 @default.
• W2800117622 date "2018-05-14" @default.
• W2800117622 modified "2023-10-16" @default.
• W2800117622 title "Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil" @default.
• W2800117622 cites W1509259116 @default.
• W2800117622 cites W1569904907 @default.
• W2800117622 cites W1582110722 @default.
• W2800117622 cites W1977242540 @default.
• W2800117622 cites W1994271822 @default.
• W2800117622 cites W1995623997 @default.
• W2800117622 cites W1996973067 @default.
• W2800117622 cites W2005501262 @default.
• W2800117622 cites W2017913960 @default.
• W2800117622 cites W2024087293 @default.
• W2800117622 cites W2030405016 @default.
• W2800117622 cites W2033558724 @default.
• W2800117622 cites W2044106830 @default.
• W2800117622 cites W2044512153 @default.
• W2800117622 cites W2047641870 @default.
• W2800117622 cites W2051283137 @default.
• W2800117622 cites W2055224779 @default.
• W2800117622 cites W2062834761 @default.
• W2800117622 cites W2081028743 @default.
• W2800117622 cites W2086987955 @default.
• W2800117622 cites W2090665495 @default.
• W2800117622 cites W2100609606 @default.
• W2800117622 cites W2109088899 @default.
• W2800117622 cites W2110320988 @default.
• W2800117622 cites W2129349128 @default.
• W2800117622 cites W2132149924 @default.
• W2800117622 cites W2150625070 @default.
• W2800117622 cites W2345616862 @default.
• W2800117622 cites W2560613109 @default.
• W2800117622 cites W2590345771 @default.
• W2800117622 cites W2743034332 @default.
• W2800117622 doi "https://doi.org/10.1590/0074-02760170489" @default.
• W2800117622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5961924" @default.
• W2800117622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29768622" @default.
• W2800117622 hasPublicationYear "2018" @default.
• W2800117622 type Work @default.
• W2800117622 sameAs 2800117622 @default.
• W2800117622 citedByCount "10" @default.
• W2800117622 countsByYear W28001176222018 @default.
• W2800117622 countsByYear W28001176222019 @default.
• W2800117622 countsByYear W28001176222020 @default.
• W2800117622 countsByYear W28001176222022 @default.
• W2800117622 countsByYear W28001176222023 @default.
• W2800117622 crossrefType "journal-article" @default.
• W2800117622 hasAuthorship W2800117622A5001118043 @default.
• W2800117622 hasAuthorship W2800117622A5018954082 @default.
• W2800117622 hasAuthorship W2800117622A5020546900 @default.
• W2800117622 hasAuthorship W2800117622A5027126625 @default.
• W2800117622 hasAuthorship W2800117622A5037399431 @default.
• W2800117622 hasAuthorship W2800117622A5039645227 @default.
• W2800117622 hasAuthorship W2800117622A5072058550 @default.
• W2800117622 hasAuthorship W2800117622A5074369942 @default.
• W2800117622 hasAuthorship W2800117622A5075594976 @default.
• W2800117622 hasAuthorship W2800117622A5076343777 @default.
• W2800117622 hasAuthorship W2800117622A5086132806 @default.
• W2800117622 hasAuthorship W2800117622A5089054320 @default.
• W2800117622 hasBestOaLocation W28001176221 @default.
• W2800117622 hasConcept C104317684 @default.
• W2800117622 hasConcept C112418997 @default.
• W2800117622 hasConcept C11988809 @default.
• W2800117622 hasConcept C126322002 @default.
• W2800117622 hasConcept C135763542 @default.
• W2800117622 hasConcept C153209595 @default.
• W2800117622 hasConcept C17991360 @default.
• W2800117622 hasConcept C187316574 @default.
• W2800117622 hasConcept C203014093 @default.
• W2800117622 hasConcept C2777910003 @default.
• W2800117622 hasConcept C2778690821 @default.
• W2800117622 hasConcept C2779134260 @default.
• W2800117622 hasConcept C54355233 @default.
• W2800117622 hasConcept C71924100 @default.
• W2800117622 hasConcept C86803240 @default.
• W2800117622 hasConcept C90924648 @default.
• W2800117622 hasConceptScore W2800117622C104317684 @default.
• W2800117622 hasConceptScore W2800117622C112418997 @default.
• W2800117622 hasConceptScore W2800117622C11988809 @default.
• W2800117622 hasConceptScore W2800117622C126322002 @default.
• W2800117622 hasConceptScore W2800117622C135763542 @default.
• W2800117622 hasConceptScore W2800117622C153209595 @default.
• W2800117622 hasConceptScore W2800117622C17991360 @default.
• W2800117622 hasConceptScore W2800117622C187316574 @default.
• W2800117622 hasConceptScore W2800117622C203014093 @default.
• W2800117622 hasConceptScore W2800117622C2777910003 @default.

• next