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- W2800128771 abstract "Background and objective: Streptococcus mutans and Lactobacillus acidophilus are bacteria producing tooth decay which by adhering to tooth surfaces contribute to its pathogenesis. By increasing bacterial resistance to antibiotics, along with other high-cost of treatment, the use of natural antibacterial agents is essential. In this regard, the role of curcumin on the adhesion process of cariogenic pathogens has been studied.& para;& para;Materials and Methods: The bacterial strains of Streptococcus mutans (PTCC1683) and Lactobacillus acidophilus (PTCC1643) were obtained from the Iranian Research Organization for Science and Technology). The early growth of the bacteria was carried out in BHI medium, and then the concentration of microorganisms reached the half-MacFar-land standard, and using different concentrations of curcumin (1, 2, 4, 8, 16, 31, 25, 52, 62, 125, 250, 500 mu g/mI) obtained by serial dilution method the substances were mixed. BHI medium without bacteria was considered as negative control. Then samples were incubated for 24 hours at 37 degrees C in anaerobic conditions for determining the minimum inhibitory concentration. Inhibitory concentrations determined in the previous step were used to determine adhesion using the amount of light absorbance determination method.& para;& para;Results: The minimum inhibitory concentration of growth was determined in both bacterial strains of 250 mu g/ml. The results showed a decrease in light absorption with increasing curcumin concentration (P<0.001), which indicates a high correlation (correlation coefficient of -0.93) of curcumin concentrations with reverse adhesion.& para;& para;Conclusion: Adhesion is the most important factor in tooth decay and its reduction is an effective solution in preventing the disease. Considering the inhibitory role of curcumin on growth and binding of bacterial strains, this curcuminoid agent is considered as a potent anti-decay agent." @default.
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- W2800128771 date "2017-11-01" @default.
- W2800128771 modified "2023-10-14" @default.
- W2800128771 title "The Effect of Curcumin on Growth and Adherence of Major Microorganisms Causing Tooth Decay" @default.
- W2800128771 doi "https://doi.org/10.5742/mewfm.2017.93128" @default.
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