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• W2800141034 abstract "Significance RNAs contain over 100 types of chemical modifications, and N 6 -methyladenosine (m 6 A) is the most common internal modification in eukaryotic mRNA. m 6 A is involved in a variety of important biological processes, including sex determination in Drosophila , by modifying Sxl pre-mRNA and regulating its alternative splicing. m 6 A is installed by a large methyltransferase complex called the m 6 A “writer.” We have identified xio as a component of the Drosophila sex determination pathway based on its female-to-male transformation phenotypes. Xio interacts with other m 6 A writer subunits, and its loss of function shows typical phenotypes associated with other m 6 A factors, such as Sxl splicing misregulation, adult defects, and reduced m 6 A levels. Therefore, we conclude that Xio is a member of the m 6 A writer complex." @default.
• W2800141034 created "2018-05-17" @default.
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• W2800141034 date "2018-03-19" @default.
• W2800141034 modified "2023-10-16" @default.
• W2800141034 title "Xio is a component of the <i>Drosophila</i> sex determination pathway and RNA <i>N</i> ⁶ -methyladenosine methyltransferase complex" @default.
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• W2800141034 doi "https://doi.org/10.1073/pnas.1720945115" @default.
• W2800141034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5889661" @default.
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