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- W2800142209 abstract "We have previously shown that the C-type Natriuretic Peptide (CNP), a peptide produced by lungs, is able to impact Pseudomonas aeruginosa physiology. In the present work, the effect of CNP at different concentrations on P. aeruginosa biofilm formation was studied and the mechanisms of action of this human hormone on P. aeruginosa were deciphered. CNP was shown to inhibit dynamic biofilm formation in a dose-dependent manner without affecting the bacterial growth at any tested concentrations. The most effective concentrations were 1 and 0.1 µM. At 0.1 µM, the biofilm formation inhibition was fully dependent on the CNP sensor protein AmiC, whereas it was only partially AmiC-dependent at 1 µM, revealing the existence of a second AmiC-independent mode of action of CNP on P. aeruginosa. At 1 µM, CNP reduced both P. aeruginosa adhesion on glass and di-rhamnolipid production and also increased the bacterial membrane fluidity. The various effects of CNP at 1 µM and 0.1 µM on P. aeruginosa shown here should have major consequences to design drugs for biofilm treatment or prevention." @default.
- W2800142209 created "2018-05-17" @default.
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- W2800142209 date "2018-04-24" @default.
- W2800142209 modified "2023-09-25" @default.
- W2800142209 title "Different Dose-Dependent Modes of Action of C-Type Natriuretic Peptide on Pseudomonas aeruginosa Biofilm Formation" @default.
- W2800142209 cites W1531562640 @default.
- W2800142209 cites W1542606742 @default.
- W2800142209 cites W1543474898 @default.
- W2800142209 cites W1567076594 @default.
- W2800142209 cites W1584351787 @default.
- W2800142209 cites W1732205261 @default.
- W2800142209 cites W1914433542 @default.
- W2800142209 cites W1938334973 @default.
- W2800142209 cites W1966552407 @default.
- W2800142209 cites W1970160019 @default.
- W2800142209 cites W1975656598 @default.
- W2800142209 cites W1977938958 @default.
- W2800142209 cites W1979583433 @default.
- W2800142209 cites W1980647380 @default.
- W2800142209 cites W1988874714 @default.
- W2800142209 cites W1992286254 @default.
- W2800142209 cites W1995618975 @default.
- W2800142209 cites W2002059197 @default.
- W2800142209 cites W2012359871 @default.
- W2800142209 cites W2016158447 @default.
- W2800142209 cites W2020211786 @default.
- W2800142209 cites W2021639750 @default.
- W2800142209 cites W2027375167 @default.
- W2800142209 cites W2034320470 @default.
- W2800142209 cites W2037966968 @default.
- W2800142209 cites W2049141720 @default.
- W2800142209 cites W2055753580 @default.
- W2800142209 cites W2075575314 @default.
- W2800142209 cites W2076518284 @default.
- W2800142209 cites W2076969138 @default.
- W2800142209 cites W2084488770 @default.
- W2800142209 cites W2085147597 @default.
- W2800142209 cites W2086601172 @default.
- W2800142209 cites W2091513339 @default.
- W2800142209 cites W2092097777 @default.
- W2800142209 cites W2099540110 @default.
- W2800142209 cites W2101217433 @default.
- W2800142209 cites W2104029963 @default.
- W2800142209 cites W2108107786 @default.
- W2800142209 cites W2108226120 @default.
- W2800142209 cites W2110017940 @default.
- W2800142209 cites W2116527263 @default.
- W2800142209 cites W2127535305 @default.
- W2800142209 cites W2133425351 @default.
- W2800142209 cites W2133900508 @default.
- W2800142209 cites W2134398126 @default.
- W2800142209 cites W2134408956 @default.
- W2800142209 cites W2136327514 @default.
- W2800142209 cites W2137081432 @default.
- W2800142209 cites W2146729525 @default.
- W2800142209 cites W2158438350 @default.
- W2800142209 cites W2159273899 @default.
- W2800142209 cites W2165850276 @default.
- W2800142209 cites W2168027558 @default.
- W2800142209 cites W2183640794 @default.
- W2800142209 cites W2259553490 @default.
- W2800142209 cites W2278676024 @default.
- W2800142209 cites W2288590105 @default.
- W2800142209 cites W2315129821 @default.
- W2800142209 cites W2328167306 @default.
- W2800142209 cites W2341415062 @default.
- W2800142209 cites W2414611100 @default.
- W2800142209 cites W2415166553 @default.
- W2800142209 cites W2433272157 @default.
- W2800142209 cites W2463118776 @default.
- W2800142209 cites W2530698528 @default.
- W2800142209 cites W2540336339 @default.
- W2800142209 cites W2582645842 @default.
- W2800142209 cites W2600619077 @default.
- W2800142209 cites W2606104114 @default.
- W2800142209 cites W2678288201 @default.
- W2800142209 cites W2729267984 @default.
- W2800142209 cites W2735601417 @default.
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- W2800142209 doi "https://doi.org/10.3390/pathogens7020047" @default.
- W2800142209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6026938" @default.
- W2800142209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29695043" @default.