FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800163500> ?p ?o ?g. }

• W2800163500 endingPage "2619" @default.
• W2800163500 startingPage "2613" @default.
• W2800163500 abstract "Abstract Objective Insulin secretion (IS) declines with age, which increases the risk of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in older adults. IS is regulated by the incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Here we tested the hypotheses that incretin release is lower in older adults and that this decline is associated with β-cell dysfunction. Research Design A total of 40 young (25 ± 3 years) and 53 older (74 ± 7 years) lean nondiabetic subjects underwent a 2-hour oral glucose tolerance test (OGTT). Based on the OGTT, subjects were divided into three groups: young subjects with normal glucose tolerance (Y-NGT; n = 40), older subjects with normal glucose tolerance (O-NGT; n = 32), and older subjects with IGT (O-IGT; n = 21). Main Outcome Measures Plasma insulin, C-peptide, GLP-1, and GIP concentrations were measured every 15 to 30 minutes. We quantitated insulin sensitivity (Matsuda index) and insulin secretory rate (ISR) by deconvolution of C-peptide with the calculation of β-cell glucose sensitivity. Results Matsuda index, early phase ISR (0 to 30 minutes), and parameters of β-cell function were lower in O-IGT than in Y-NGT subjects but not in O-NGT subjects. GLP-1 concentrations were elevated in both older groups [GLP-1 area under the curve (AUC)0–120 was 2.8 ± 0.1 in Y-NGT, 3.8 ± 0.5 in O-NGT, and 3.7 ± 0.4 nmol/L∙120 minutes in O-IGT subjects; P < 0.05], whereas GIP secretion was higher in O-NGT than in Y-NGT subjects (GIP AUC0–120 was 4.7 ± 0.3 in Y-NGT, 6.0 ± 0.4 in O-NGT, and 4.8 ± 0.3 nmol/L∙120 minutes in O-IGT subjects; P < 0.05). Conclusions Aging is associated with an exaggerated GLP-1 secretory response. However, it was not sufficient to increase insulin first-phase release in O-IGT and overcome insulin resistance." @default.
• W2800163500 created "2018-05-17" @default.
• W2800163500 creator A5016529952 @default.
• W2800163500 creator A5034471398 @default.
• W2800163500 creator A5064556745 @default.
• W2800163500 creator A5076233027 @default.
• W2800163500 creator A5085434984 @default.
• W2800163500 creator A5091912602 @default.
• W2800163500 date "2018-04-16" @default.
• W2800163500 modified "2023-10-18" @default.
• W2800163500 title "Older Subjects With β-Cell Dysfunction Have an Accentuated Incretin Release" @default.
• W2800163500 cites W1968133269 @default.
• W2800163500 cites W1968766654 @default.
• W2800163500 cites W1992016036 @default.
• W2800163500 cites W2017881732 @default.
• W2800163500 cites W2036250975 @default.
• W2800163500 cites W2037808521 @default.
• W2800163500 cites W2042200044 @default.
• W2800163500 cites W2042362312 @default.
• W2800163500 cites W2047022776 @default.
• W2800163500 cites W2048876290 @default.
• W2800163500 cites W2055841488 @default.
• W2800163500 cites W2066746642 @default.
• W2800163500 cites W2075699790 @default.
• W2800163500 cites W2091101612 @default.
• W2800163500 cites W2091422900 @default.
• W2800163500 cites W2100958925 @default.
• W2800163500 cites W2101153844 @default.
• W2800163500 cites W2108975920 @default.
• W2800163500 cites W2112502827 @default.
• W2800163500 cites W2114434280 @default.
• W2800163500 cites W2114437291 @default.
• W2800163500 cites W2131136365 @default.
• W2800163500 cites W2132285082 @default.
• W2800163500 cites W2133795831 @default.
• W2800163500 cites W2141569406 @default.
• W2800163500 cites W2141742385 @default.
• W2800163500 cites W2145818242 @default.
• W2800163500 cites W2146195489 @default.
• W2800163500 cites W2150865391 @default.
• W2800163500 cites W2160234571 @default.
• W2800163500 cites W2169274492 @default.
• W2800163500 cites W2170932033 @default.
• W2800163500 cites W2232765666 @default.
• W2800163500 cites W4253280909 @default.
• W2800163500 doi "https://doi.org/10.1210/jc.2018-00260" @default.
• W2800163500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6669818" @default.
• W2800163500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29672742" @default.
• W2800163500 hasPublicationYear "2018" @default.
• W2800163500 type Work @default.
• W2800163500 sameAs 2800163500 @default.
• W2800163500 citedByCount "14" @default.
• W2800163500 countsByYear W28001635002019 @default.
• W2800163500 countsByYear W28001635002020 @default.
• W2800163500 countsByYear W28001635002021 @default.
• W2800163500 countsByYear W28001635002022 @default.
• W2800163500 countsByYear W28001635002023 @default.
• W2800163500 crossrefType "journal-article" @default.
• W2800163500 hasAuthorship W2800163500A5016529952 @default.
• W2800163500 hasAuthorship W2800163500A5034471398 @default.
• W2800163500 hasAuthorship W2800163500A5064556745 @default.
• W2800163500 hasAuthorship W2800163500A5076233027 @default.
• W2800163500 hasAuthorship W2800163500A5085434984 @default.
• W2800163500 hasAuthorship W2800163500A5091912602 @default.
• W2800163500 hasBestOaLocation W28001635001 @default.
• W2800163500 hasConcept C126322002 @default.
• W2800163500 hasConcept C134018914 @default.
• W2800163500 hasConcept C2776398474 @default.
• W2800163500 hasConcept C2777180221 @default.
• W2800163500 hasConcept C2777391703 @default.
• W2800163500 hasConcept C2778881409 @default.
• W2800163500 hasConcept C2779306644 @default.
• W2800163500 hasConcept C2780352109 @default.
• W2800163500 hasConcept C2780609358 @default.
• W2800163500 hasConcept C2780833929 @default.
• W2800163500 hasConcept C555293320 @default.
• W2800163500 hasConcept C71924100 @default.
• W2800163500 hasConceptScore W2800163500C126322002 @default.
• W2800163500 hasConceptScore W2800163500C134018914 @default.
• W2800163500 hasConceptScore W2800163500C2776398474 @default.
• W2800163500 hasConceptScore W2800163500C2777180221 @default.
• W2800163500 hasConceptScore W2800163500C2777391703 @default.
• W2800163500 hasConceptScore W2800163500C2778881409 @default.
• W2800163500 hasConceptScore W2800163500C2779306644 @default.
• W2800163500 hasConceptScore W2800163500C2780352109 @default.
• W2800163500 hasConceptScore W2800163500C2780609358 @default.
• W2800163500 hasConceptScore W2800163500C2780833929 @default.
• W2800163500 hasConceptScore W2800163500C555293320 @default.
• W2800163500 hasConceptScore W2800163500C71924100 @default.
• W2800163500 hasFunder F4320306089 @default.
• W2800163500 hasFunder F4320322651 @default.
• W2800163500 hasFunder F4320332161 @default.
• W2800163500 hasIssue "7" @default.
• W2800163500 hasLocation W28001635001 @default.
• W2800163500 hasLocation W28001635002 @default.
• W2800163500 hasLocation W28001635003 @default.
• W2800163500 hasOpenAccess W2800163500 @default.
• W2800163500 hasPrimaryLocation W28001635001 @default.

• next