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• W2800165788 abstract "<b><i>Aim:</i></b> <i>Helicobacter pylori</i>-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early <i>H. pylori</i>-naïve GCs. <b><i>Subjects and Methods:</i></b> Of 666 patients with GC resected by endoscopic submucosal dissection, <i>H. pylori</i>-naïve patients were extracted according to the definition: no <i>H. pylori</i> eradication history, negative for serum <i>H. pylori</i>-antibody and current <i>H. pylori</i>-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology. <b><i>Results:</i></b> It was found that 16 GCs were <i>H. pylori</i>-naïve, and classified into undifferentiated and differentiated type adenocarcinoma. All 9 undifferentiated type GCs were pale, depressed, mucosal pure signet ring cell adenocarcinoma except one of them and 7 differentiated type GCs were classified into 3 fundic gland type GCs and 4 foveolar type GCs. All fundic gland type GCs positive for PG-1 were cardia small submucosal tumor (SMT)-like protrusions with dilated vessels on the surface. All 4 foveolar type GCs were composed of dysplastic clear cells resembling foveolar epithelium, negative for PG-1 but positive for mucin 6 (MUC6) and MUC5AC. Endoscopically, all were laterally spreading elevations with papillary or villous surface. <b><i>Conclusions:</i></b> <i>H. pylori</i>-naïve GCs were infrequent at 2.5%, and classified into 3 types: a small pale depression of signet ring cell adenocarcinoma, a small SMT-like protrusion of fundic gland type GC, and a large laterally spreading elevation of foveolar type GC." @default.
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• W2800165788 date "2018-01-01" @default.
• W2800165788 modified "2023-10-14" @default.
• W2800165788 title "Characterization of <b><i>Helicobacter pylori</i></b>-Naïve Early Gastric Cancers" @default.
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• W2800165788 doi "https://doi.org/10.1159/000487795" @default.
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