Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800184844> ?p ?o ?g. }
- W2800184844 abstract "Ischemic heart failure is the leading cause of mortality worldwide. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling in cardiac mesenchymal stem cells (MSCs) could improve myocardial infarction (MI) healing. Epicardial erythropoietin (EPO; 300 U kg-1) was compared with intraperitoneal and intramyocardial EPO treatments after acute MI in rats (n=156). Real-time PCR and confocal microscopy revealed that epicardial EPO treatment enhanced levels of intracardiac regenerative key indicators (SDF-1, CXCR4, CD34, Bcl-2, cyclin D1, Cdc2 and MMP2), induced transforming growth factor β (TGF-β)/WNT signaling in intramyocardial MSC niches through the direct activation of AKT and upregulation of upstream signals FOS and Fzd7, and augmented intracardiac mesenchymal proliferation 24 h after MI. Cardiac catheterization and tissue analysis showed superior cardiac functions, beneficial remodeling and increased capillary density 6 weeks after MI. Concomitant fluorescence-activated cell sorting, co-cultures with neonatal cardiomyocytes, angiogenesis assays, ELISA, western blotting and RAMAN spectroscopy demonstrated that EPO could promote cardiomyogenic differentiation that was specific of tissue origin and enhance paracrine angiogenetic activity in cardiac CD45-CD44+DDR2+ MSCs. Epicardial EPO delivery might be the optimal route for efficient upregulation of regenerative key signals after acute MI. Early EPO-mediated stimulation of mesenchymal proliferation, synergistic angiogenesis with cardiac MSCs and direct induction of TGF-β/WNT signaling in intramyocardial cardiac MSCs could initiate an accelerated healing process that enhances cardiac recovery." @default.
- W2800184844 created "2018-05-17" @default.
- W2800184844 creator A5000385674 @default.
- W2800184844 creator A5012794413 @default.
- W2800184844 creator A5012844121 @default.
- W2800184844 creator A5013959327 @default.
- W2800184844 creator A5014723339 @default.
- W2800184844 creator A5018424227 @default.
- W2800184844 creator A5019793360 @default.
- W2800184844 creator A5035005191 @default.
- W2800184844 creator A5037497626 @default.
- W2800184844 creator A5038809102 @default.
- W2800184844 creator A5046008381 @default.
- W2800184844 creator A5055249856 @default.
- W2800184844 creator A5057505206 @default.
- W2800184844 creator A5058708835 @default.
- W2800184844 creator A5062218486 @default.
- W2800184844 creator A5062415727 @default.
- W2800184844 creator A5066711933 @default.
- W2800184844 creator A5081747456 @default.
- W2800184844 creator A5090956775 @default.
- W2800184844 date "2018-01-01" @default.
- W2800184844 modified "2023-10-14" @default.
- W2800184844 title "Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart" @default.
- W2800184844 cites W121574336 @default.
- W2800184844 cites W1560586627 @default.
- W2800184844 cites W1963501822 @default.
- W2800184844 cites W1967688133 @default.
- W2800184844 cites W1976120430 @default.
- W2800184844 cites W1979286224 @default.
- W2800184844 cites W1982815250 @default.
- W2800184844 cites W1983546040 @default.
- W2800184844 cites W1988026821 @default.
- W2800184844 cites W1988832870 @default.
- W2800184844 cites W1990163699 @default.
- W2800184844 cites W1991962824 @default.
- W2800184844 cites W1994686590 @default.
- W2800184844 cites W1998155376 @default.
- W2800184844 cites W2000159717 @default.
- W2800184844 cites W2003481724 @default.
- W2800184844 cites W2010193681 @default.
- W2800184844 cites W2017088597 @default.
- W2800184844 cites W2017735895 @default.
- W2800184844 cites W2027495896 @default.
- W2800184844 cites W2043181869 @default.
- W2800184844 cites W2043377295 @default.
- W2800184844 cites W2051075947 @default.
- W2800184844 cites W2053581283 @default.
- W2800184844 cites W2058916621 @default.
- W2800184844 cites W2062729839 @default.
- W2800184844 cites W2067523605 @default.
- W2800184844 cites W2068732521 @default.
- W2800184844 cites W2069878165 @default.
- W2800184844 cites W2070772918 @default.
- W2800184844 cites W2073062891 @default.
- W2800184844 cites W2073319647 @default.
- W2800184844 cites W2075128911 @default.
- W2800184844 cites W2077912859 @default.
- W2800184844 cites W2082665949 @default.
- W2800184844 cites W2082714048 @default.
- W2800184844 cites W2084037323 @default.
- W2800184844 cites W2085448902 @default.
- W2800184844 cites W2095029191 @default.
- W2800184844 cites W2098419906 @default.
- W2800184844 cites W2098590189 @default.
- W2800184844 cites W2100172364 @default.
- W2800184844 cites W2105197388 @default.
- W2800184844 cites W2106586369 @default.
- W2800184844 cites W2108712459 @default.
- W2800184844 cites W2113619226 @default.
- W2800184844 cites W2120296099 @default.
- W2800184844 cites W2124262472 @default.
- W2800184844 cites W2125916283 @default.
- W2800184844 cites W2129352300 @default.
- W2800184844 cites W2133549942 @default.
- W2800184844 cites W2139634571 @default.
- W2800184844 cites W2146700631 @default.
- W2800184844 cites W2151584797 @default.
- W2800184844 cites W2152798042 @default.
- W2800184844 cites W2157312122 @default.
- W2800184844 cites W2161182825 @default.
- W2800184844 cites W2164963842 @default.
- W2800184844 cites W2165160576 @default.
- W2800184844 cites W2167202160 @default.
- W2800184844 cites W2170320140 @default.
- W2800184844 cites W2208241522 @default.
- W2800184844 cites W2312328387 @default.
- W2800184844 cites W2314186027 @default.
- W2800184844 cites W2330215089 @default.
- W2800184844 cites W2346123264 @default.
- W2800184844 cites W2503319999 @default.
- W2800184844 cites W2525605182 @default.
- W2800184844 cites W2746205007 @default.
- W2800184844 cites W2765760798 @default.
- W2800184844 cites W319008287 @default.
- W2800184844 cites W4238768614 @default.
- W2800184844 cites W4240376242 @default.
- W2800184844 doi "https://doi.org/10.1242/dmm.033282" @default.
- W2800184844 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6031356" @default.
- W2800184844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29752300" @default.