Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800192344> ?p ?o ?g. }
- W2800192344 endingPage "159" @default.
- W2800192344 startingPage "159" @default.
- W2800192344 abstract "The widespread use of next generation sequencing (NGS) has led to a refined understanding of the genomics of colorectal cancer (CRC). However, progress in the use of molecular biomarkers in standard practice has been slow, and there is no approved targeted therapy for CRC based on a positive predictive marker yet. In this review, we will first summarize biomarkers with clinical utility in standard practice or targeted therapy trials and then consider how to rationally design clinical trials to more effectively target CRC. Specifically, we will discuss current clinical applications of genomic information consisting of the use of the MAPK (mitogen-activated protein kinase) pathway genes KRAS, NRAS, and BRAF as prognostic and predictive biomarkers for standard treatment, risk stratification by primary tumor site and consideration of tumor laterality in patient selection for epidermal growth factor receptor (EGFR) antibody treatment, and the evaluation for genomic biomarkers, including BRAF V600E, HER2 amplification, and gene rearrangements, for targeted therapies in clinical trials. Applying lessons from targeted therapy trials in CRC, we now appreciate that both tumor genomics and tissue of origin affect targeted therapy response and that the development of resistance to targeted therapies is dynamic and often subclonal. Based on these understandings, we propose the design of adaptive clinical trials that evaluate real-time pharmacodynamic markers and monitor tumor subpopulations during the course of treatment to overcome challenges targeting genetic drivers in CRC." @default.
- W2800192344 created "2018-05-17" @default.
- W2800192344 creator A5038339239 @default.
- W2800192344 creator A5070003582 @default.
- W2800192344 date "2018-05-01" @default.
- W2800192344 modified "2023-10-18" @default.
- W2800192344 title "Colorectal cancer genomics and designing rational trials" @default.
- W2800192344 cites W1597604324 @default.
- W2800192344 cites W1727309928 @default.
- W2800192344 cites W1799482054 @default.
- W2800192344 cites W1846586690 @default.
- W2800192344 cites W1875361486 @default.
- W2800192344 cites W1892665108 @default.
- W2800192344 cites W1922733886 @default.
- W2800192344 cites W1934094702 @default.
- W2800192344 cites W1972070251 @default.
- W2800192344 cites W1979188008 @default.
- W2800192344 cites W1985199765 @default.
- W2800192344 cites W1987443121 @default.
- W2800192344 cites W2000028774 @default.
- W2800192344 cites W2001258296 @default.
- W2800192344 cites W2004295816 @default.
- W2800192344 cites W2005189737 @default.
- W2800192344 cites W2014881369 @default.
- W2800192344 cites W2027371008 @default.
- W2800192344 cites W2029684529 @default.
- W2800192344 cites W2034338421 @default.
- W2800192344 cites W2053343049 @default.
- W2800192344 cites W2058390096 @default.
- W2800192344 cites W2062109911 @default.
- W2800192344 cites W2063985381 @default.
- W2800192344 cites W2072276422 @default.
- W2800192344 cites W2077428590 @default.
- W2800192344 cites W2085633477 @default.
- W2800192344 cites W2091493266 @default.
- W2800192344 cites W2097121246 @default.
- W2800192344 cites W2100439220 @default.
- W2800192344 cites W2103320273 @default.
- W2800192344 cites W2106789440 @default.
- W2800192344 cites W2110682589 @default.
- W2800192344 cites W2112807374 @default.
- W2800192344 cites W2116731538 @default.
- W2800192344 cites W2120921373 @default.
- W2800192344 cites W2128542677 @default.
- W2800192344 cites W2129998117 @default.
- W2800192344 cites W2133523341 @default.
- W2800192344 cites W2134142320 @default.
- W2800192344 cites W2145247101 @default.
- W2800192344 cites W2146737519 @default.
- W2800192344 cites W2152205589 @default.
- W2800192344 cites W2152454229 @default.
- W2800192344 cites W2155311724 @default.
- W2800192344 cites W2158863975 @default.
- W2800192344 cites W2160766792 @default.
- W2800192344 cites W2163188200 @default.
- W2800192344 cites W2168213749 @default.
- W2800192344 cites W2249356557 @default.
- W2800192344 cites W2262414037 @default.
- W2800192344 cites W2292375548 @default.
- W2800192344 cites W2318605753 @default.
- W2800192344 cites W2336815607 @default.
- W2800192344 cites W2409420104 @default.
- W2800192344 cites W2527263072 @default.
- W2800192344 cites W2531319683 @default.
- W2800192344 cites W2547299751 @default.
- W2800192344 cites W2547430251 @default.
- W2800192344 cites W2547630624 @default.
- W2800192344 cites W2560160922 @default.
- W2800192344 cites W2586159641 @default.
- W2800192344 cites W2590917652 @default.
- W2800192344 cites W2598954950 @default.
- W2800192344 cites W2606495925 @default.
- W2800192344 cites W2609352512 @default.
- W2800192344 cites W2613375073 @default.
- W2800192344 cites W2619551752 @default.
- W2800192344 cites W2621165134 @default.
- W2800192344 cites W2622499649 @default.
- W2800192344 cites W2739132742 @default.
- W2800192344 cites W2739964468 @default.
- W2800192344 cites W2744203203 @default.
- W2800192344 cites W2760461398 @default.
- W2800192344 cites W2783112448 @default.
- W2800192344 cites W2783494975 @default.
- W2800192344 cites W2790254562 @default.
- W2800192344 cites W2791410762 @default.
- W2800192344 cites W4244654711 @default.
- W2800192344 cites W4250745281 @default.
- W2800192344 doi "https://doi.org/10.21037/atm.2018.03.27" @default.
- W2800192344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5985274" @default.
- W2800192344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29911107" @default.
- W2800192344 hasPublicationYear "2018" @default.
- W2800192344 type Work @default.
- W2800192344 sameAs 2800192344 @default.
- W2800192344 citedByCount "18" @default.
- W2800192344 countsByYear W28001923442019 @default.
- W2800192344 countsByYear W28001923442020 @default.
- W2800192344 countsByYear W28001923442021 @default.
- W2800192344 countsByYear W28001923442022 @default.