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- W2800199906 abstract "The androgen receptor (AR) promoter contains guanine-rich regions that are able to fold into polymorphic G-quadruplex (GQ) structures, and whose deletion decreases AR gene transcription. Our attention was focused on this region because of the frequent termination of sequencing reactions during promoter methylation studies. UV and circular dichroism (CD) spectroscopy of synthetic oligonucleotides encompassing these guanine-rich regions suggested a parallel quadruplex topology with three guanine quartets and three side loops in the three cases. Melting curves revealed a lower thermostability of the human GQ compared to the rat/mouse QG structures, which is attributed to the presence of a longer central loop in the former. One molecular model is proposed for the highly similar sequences in the rat/mouse. Due to the polymorphism resulting from possible arrangements of the guanine tracts, two models were derived for the human GQ. Molecular dynamics (MD) simulations determined that both models for the human GQ had higher flexibility and lower stability than the rodent GQ models. These properties result from the presence of a longer central loop in the human GQ models, which contains 11 and 13 nucleotides, in comparison to the 2-nucleotide long loop in the rat/mouse GQ. Overall, the unveiled structural and dynamics features provide sufficient detail for the intelligent design of drugs targeting the human AR promoter." @default.
- W2800199906 created "2018-05-17" @default.
- W2800199906 creator A5000288854 @default.
- W2800199906 creator A5014581818 @default.
- W2800199906 creator A5014630973 @default.
- W2800199906 date "2018-09-01" @default.
- W2800199906 modified "2023-10-16" @default.
- W2800199906 title "Human-specific features of the G-quadruplex in the androgen receptor gene promoter: A comparative structural and dynamics study" @default.
- W2800199906 cites W1537652800 @default.
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- W2800199906 cites W1969583921 @default.
- W2800199906 cites W1975690779 @default.
- W2800199906 cites W1978477477 @default.
- W2800199906 cites W1978670494 @default.
- W2800199906 cites W1985982026 @default.
- W2800199906 cites W1986648841 @default.
- W2800199906 cites W1990635146 @default.
- W2800199906 cites W1991590162 @default.
- W2800199906 cites W1995730272 @default.
- W2800199906 cites W1998838965 @default.
- W2800199906 cites W1998940503 @default.
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- W2800199906 cites W2037827118 @default.
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- W2800199906 cites W2043537095 @default.
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- W2800199906 doi "https://doi.org/10.1016/j.jsbmb.2018.04.015" @default.
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