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• W2800200410 startingPage "91" @default.
• W2800200410 abstract "As pharmaceutical and biotechnology industries develop new chemical compounds to improve production processes and products, traditional methods of toxicity screening are inadequately keeping up with the demand for safety testing. The conventional approach for screening compounds with embryotoxic potential heavily relies on animal models. These models have been demonstrated to be time-intensive, be expensive, and bring forth additional ethical challenges. Such limitations of animal testing have created an eagerness among researchers to develop more predictive in vitro alternative screening assays. The most promising in vitro approach at modernizing toxicity tests is the use of pluripotent stem cells. One kind of pluripotent stem cell, the embryonic stem cell, is the foundation of one of the most promising in vitro embryotoxicity assays: the embryonic stem cell test (EST). The EST assesses the general cytotoxicity of a compound on the embryonic cell, as well as the effect of the putative toxicant on the genesis of a specific tissue endpoint. Importantly, unlike other in vitro models, the EST obviates the need to sacrifice pregnant animals. Though determined suitable for regulatory standards, the classic EST, which is based on mouse cells, is limited in its endpoint analysis and efficient prediction of human response. This book chapter provides an overview of the EST, explains the various sources of pluripotent stem cells, the features that make them attractive for use in embryotoxicity screens or analysis of individual compounds, and illustrates attempts to incorporate human pluripotent stem cells in the prediction of embryotoxicity." @default.
• W2800200410 created "2018-05-17" @default.
• W2800200410 creator A5027369548 @default.
• W2800200410 creator A5070916082 @default.
• W2800200410 date "2018-04-16" @default.
• W2800200410 modified "2023-10-16" @default.
• W2800200410 title "Risk Assessment Using Human Pluripotent Stem Cells: Recent Advances in Developmental Toxicity Screens" @default.
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