FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800214805> ?p ?o ?g. }

• W2800214805 endingPage "xxii" @default.
• W2800214805 startingPage "xv" @default.
• W2800214805 abstract "To elucidate the issues that have prevented successful translation of neuroprotective therapeutic modalities for retinal disease from the preclinical to the clinical realm and to suggest strategies to circumvent these barriers in order to develop novel treatments to prevent vision loss.Interpretive essay.Review and synthesis of selected reports of neuroprotective approaches for retinal disease, with interpretation and perspective.Retinal neuroprotection is defined as any measure that reduces the death of retinal cells or axonal extensions into the optic nerve, and there is a great unmet need for such therapeutic modalities. Despite encouraging preclinical data, the translation of neuroprotective therapies to the clinic has been fraught with failure. Fundamental issues that have plagued this transition include the animal models used in preclinical studies, the reproducibility of the preclinical data, and the choice of meaningful clinical trial endpoints. Developing animal models that more aptly mimic human disease, defining a set of guidelines for preclinical evaluation of neuroprotective therapies in retinal disease, and identifying and validating biomarkers as surrogate clinical endpoints that shorten and optimize drug development timelines may circumvent some of these barriers to translation.Neuroprotective therapeutic approaches have the potential to prevent vision loss in millions of people affected with eye diseases worldwide. However, a stigma currently accompanies the concept of neuroprotection because of the many past failures to bridge the gap between the preclinical and clinical realms. Understanding and addressing the fundamental reasons for the failure of translatable research provides hope for the future development of neuroprotective therapies." @default.
• W2800214805 created "2018-05-17" @default.
• W2800214805 creator A5000274726 @default.
• W2800214805 creator A5018312148 @default.
• W2800214805 creator A5045228502 @default.
• W2800214805 creator A5055166338 @default.
• W2800214805 date "2018-08-01" @default.
• W2800214805 modified "2023-10-18" @default.
• W2800214805 title "Retinal Neuroprotection: Overcoming the Translational Roadblocks" @default.
• W2800214805 cites W1964368883 @default.
• W2800214805 cites W1966721626 @default.
• W2800214805 cites W1972955056 @default.
• W2800214805 cites W1975572742 @default.
• W2800214805 cites W1979581271 @default.
• W2800214805 cites W1992915782 @default.
• W2800214805 cites W2003199248 @default.
• W2800214805 cites W2007892539 @default.
• W2800214805 cites W2010254915 @default.
• W2800214805 cites W2030706446 @default.
• W2800214805 cites W2037197011 @default.
• W2800214805 cites W2039799157 @default.
• W2800214805 cites W2049041989 @default.
• W2800214805 cites W2067364714 @default.
• W2800214805 cites W2077785726 @default.
• W2800214805 cites W2086791741 @default.
• W2800214805 cites W2087371812 @default.
• W2800214805 cites W2094971722 @default.
• W2800214805 cites W2098642477 @default.
• W2800214805 cites W2101770484 @default.
• W2800214805 cites W2106993365 @default.
• W2800214805 cites W2115932454 @default.
• W2800214805 cites W2135138000 @default.
• W2800214805 cites W2169800603 @default.
• W2800214805 cites W2173140338 @default.
• W2800214805 cites W2182456467 @default.
• W2800214805 cites W2263429888 @default.
• W2800214805 cites W2289254711 @default.
• W2800214805 cites W2291910723 @default.
• W2800214805 cites W2471204500 @default.
• W2800214805 cites W2501579558 @default.
• W2800214805 cites W2538869024 @default.
• W2800214805 cites W2560420095 @default.
• W2800214805 cites W2588300742 @default.
• W2800214805 cites W2591686881 @default.
• W2800214805 cites W2605760719 @default.
• W2800214805 cites W2611481262 @default.
• W2800214805 cites W2614484782 @default.
• W2800214805 cites W2615160023 @default.
• W2800214805 cites W2624907204 @default.
• W2800214805 cites W2672043438 @default.
• W2800214805 cites W2687813148 @default.
• W2800214805 cites W2732996930 @default.
• W2800214805 cites W2736065260 @default.
• W2800214805 cites W2748339371 @default.
• W2800214805 cites W2749251498 @default.
• W2800214805 cites W2750510345 @default.
• W2800214805 cites W2752123745 @default.
• W2800214805 cites W2772802019 @default.
• W2800214805 cites W2782487815 @default.
• W2800214805 cites W4253875889 @default.
• W2800214805 doi "https://doi.org/10.1016/j.ajo.2018.04.012" @default.
• W2800214805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29702074" @default.
• W2800214805 hasPublicationYear "2018" @default.
• W2800214805 type Work @default.
• W2800214805 sameAs 2800214805 @default.
• W2800214805 citedByCount "11" @default.
• W2800214805 countsByYear W28002148052019 @default.
• W2800214805 countsByYear W28002148052020 @default.
• W2800214805 countsByYear W28002148052021 @default.
• W2800214805 countsByYear W28002148052022 @default.
• W2800214805 countsByYear W28002148052023 @default.
• W2800214805 crossrefType "journal-article" @default.
• W2800214805 hasAuthorship W2800214805A5000274726 @default.
• W2800214805 hasAuthorship W2800214805A5018312148 @default.
• W2800214805 hasAuthorship W2800214805A5045228502 @default.
• W2800214805 hasAuthorship W2800214805A5055166338 @default.
• W2800214805 hasConcept C128544194 @default.
• W2800214805 hasConcept C142724271 @default.
• W2800214805 hasConcept C15744967 @default.
• W2800214805 hasConcept C169760540 @default.
• W2800214805 hasConcept C177713679 @default.
• W2800214805 hasConcept C25498285 @default.
• W2800214805 hasConcept C2779134260 @default.
• W2800214805 hasConcept C535046627 @default.
• W2800214805 hasConcept C71924100 @default.
• W2800214805 hasConcept C98274493 @default.
• W2800214805 hasConceptScore W2800214805C128544194 @default.
• W2800214805 hasConceptScore W2800214805C142724271 @default.
• W2800214805 hasConceptScore W2800214805C15744967 @default.
• W2800214805 hasConceptScore W2800214805C169760540 @default.
• W2800214805 hasConceptScore W2800214805C177713679 @default.
• W2800214805 hasConceptScore W2800214805C25498285 @default.
• W2800214805 hasConceptScore W2800214805C2779134260 @default.
• W2800214805 hasConceptScore W2800214805C535046627 @default.
• W2800214805 hasConceptScore W2800214805C71924100 @default.
• W2800214805 hasConceptScore W2800214805C98274493 @default.
• W2800214805 hasLocation W28002148051 @default.
• W2800214805 hasLocation W28002148052 @default.

• next