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- W2800233075 abstract "The engineering of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR-associated proteins continues to expand the toolkit available for genome editing, reprogramming gene regulation, genome visualisation and epigenetic studies of living organisms. In this review, the emerging design principles on the use of nuclease-deficient CRISPR-based reprogramming of gene expression will be presented. The review will focus on the designs implemented in yeast both at the level of CRISPR proteins and guide RNA (gRNA), but will lend due credits to the seminal studies performed in other species where relevant. In addition to design principles, this review also highlights applications benefitting from the use of CRISPR-mediated transcriptional regulation and discusses the future directions to further expand the toolkit for nuclease-deficient reprogramming of genomes. As such, this review should be of general interest for experimentalists to get familiarised with the parameters underlying the power of reprogramming genomic functions by use of nuclease-deficient CRISPR technologies." @default.
- W2800233075 created "2018-05-17" @default.
- W2800233075 creator A5024318421 @default.
- W2800233075 date "2018-04-10" @default.
- W2800233075 modified "2023-09-27" @default.
- W2800233075 title "Design principles for nuclease-deficient CRISPR-based transcriptional regulators" @default.
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- W2800233075 doi "https://doi.org/10.1093/femsyr/foy039" @default.
- W2800233075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5932555" @default.
- W2800233075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29726937" @default.
- W2800233075 hasPublicationYear "2018" @default.
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