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- W2800233418 abstract "Osteoporosis is a widespread chronic disease characterized by low bone density, altered microstructure and bone fragility, leading to low impact fractures in affected individuals. The discovery of a few mutations that cause extremely rare human diseases has identified the WNT signaling pathway as a candidate for therapeutic intervention aimed at increasing bone mass and strength. In particular, inhibition of sclerostin, a WNT antagonist secreted by osteocytes, has proven in clinical trials to be a very efficient osteo-anabolic approach. One year of monthly administration of antibodies to sclerostin rapidly decreases bone resorption and increases bone formation and bone density at all sites, decreasing markedly fracture risk in treated patients. Their effect is however limited in time and cardiovascular adverse events have been reported in one clinical trial." @default.
- W2800233418 created "2018-05-17" @default.
- W2800233418 creator A5053072500 @default.
- W2800233418 creator A5071603809 @default.
- W2800233418 date "2018-06-01" @default.
- W2800233418 modified "2023-09-26" @default.
- W2800233418 title "Targeting WNT signaling in the treatment of osteoporosis" @default.
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- W2800233418 cites W1516916106 @default.
- W2800233418 cites W1582533387 @default.
- W2800233418 cites W1946466709 @default.
- W2800233418 cites W1970864109 @default.
- W2800233418 cites W1982395713 @default.
- W2800233418 cites W1983220846 @default.
- W2800233418 cites W1984543735 @default.
- W2800233418 cites W1985945376 @default.
- W2800233418 cites W1986085728 @default.
- W2800233418 cites W1992893431 @default.
- W2800233418 cites W1996161852 @default.
- W2800233418 cites W1997823019 @default.
- W2800233418 cites W2002073678 @default.
- W2800233418 cites W2005442458 @default.
- W2800233418 cites W2013293643 @default.
- W2800233418 cites W2017965242 @default.
- W2800233418 cites W2019196925 @default.
- W2800233418 cites W2019582558 @default.
- W2800233418 cites W2021829493 @default.
- W2800233418 cites W2028246522 @default.
- W2800233418 cites W2029509488 @default.
- W2800233418 cites W2029674033 @default.
- W2800233418 cites W2032956576 @default.
- W2800233418 cites W2037750372 @default.
- W2800233418 cites W2047882840 @default.
- W2800233418 cites W2060336303 @default.
- W2800233418 cites W2065766094 @default.
- W2800233418 cites W2068318939 @default.
- W2800233418 cites W2068916684 @default.
- W2800233418 cites W2079963757 @default.
- W2800233418 cites W2083068026 @default.
- W2800233418 cites W2086694435 @default.
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- W2800233418 cites W2090932358 @default.
- W2800233418 cites W2096627331 @default.
- W2800233418 cites W2104357139 @default.
- W2800233418 cites W2107311921 @default.
- W2800233418 cites W2108403721 @default.
- W2800233418 cites W2114649090 @default.
- W2800233418 cites W2115271834 @default.
- W2800233418 cites W2119413986 @default.
- W2800233418 cites W2135671879 @default.
- W2800233418 cites W2139133092 @default.
- W2800233418 cites W2146138547 @default.
- W2800233418 cites W2152136687 @default.
- W2800233418 cites W2154307309 @default.
- W2800233418 cites W2155377428 @default.
- W2800233418 cites W2158021558 @default.
- W2800233418 cites W2159406891 @default.
- W2800233418 cites W2160306549 @default.
- W2800233418 cites W2163341100 @default.
- W2800233418 cites W2164443365 @default.
- W2800233418 cites W2167572811 @default.
- W2800233418 cites W2169373397 @default.
- W2800233418 cites W2221806096 @default.
- W2800233418 cites W2236351428 @default.
- W2800233418 cites W2292462929 @default.
- W2800233418 cites W2520632143 @default.
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- W2800233418 cites W2771031544 @default.
- W2800233418 cites W2784497332 @default.
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- W2800233418 doi "https://doi.org/10.1016/j.coph.2018.04.011" @default.
- W2800233418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29753194" @default.
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