FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800240053> ?p ?o ?g. }

• W2800240053 abstract "Leishmania (Viannia) braziliensis is the main species involved in American tegumentary leishmaniasis. Hamster is the most susceptible model to the species of the subgenus Viannia. The appearance of the lesions is related to the initial infectious load, influencing the severity, the clinical evolution and the histopathological changes in the disease. In this study, the inflammatory immunocellular profile induced by different infective loads of L. braziliensis and its relation with the evolution and severity of the infection was evaluated in a hamster model. Hamsters (n = 60) were infected in the footpad (intradermal way) with L. braziliensis promastigotes with 104, 105 and 106 and the footpad thickness measurement was performed weekly for 45 days. On the 15th and 45th day after infection, the animals were submitted to a subcutaneous air pouch with inoculum of 106 parasites. The infected footpad and lesion drainage lymph node (LN), as well as the exudate and the air pouch tissue, were collected for evaluation of parameters such as: recruitment and cell phenotype (air pouch), parasitic load (footpad and LN, RTqPCR), cytokine expression (footpad and LN; RTqPCR) and histopathological aspects (footpad and tissue of the air pouch) It was observed that lesion appearance was inversely related to the concentration of the inoculum; while lesion aspects, parasite load and histopathological changes were directly related to the concentration of the inoculum. A mixed profile of cytokine expression was also observed in the 3 inocula and in the evaluated times. Low modulation of IL-4 and TGF-03B2 was also observed in the animals infected with 104, which may have contributed to the mild parasite load and more benign lesions, contrary to what was observed with 106. In the inocula 105 and 106 was observed an apparent deregulation of the immune response, with high expression of cytokines, probably related to the major antigenic stimulus. In summary, the results showed a tendency of the inoculum 104 to induce a more efficient infection control, probably mediated by the low modulation of IL-4, IL-10 and TGF-03B2 cytokines. In contrast, the inoculum 106 showed a trend towards a less effective control, and even through the high expression of IFN-0263 and iNOS, it also induced IL-4 and TGF-03B2, which may contribute to the chronic course of the disease. In addition, the data also suggest that the cytokine profile produced in the lymph node primo-infection may have influenced the type and the amount of cells that were recruited into air pouch tissue." @default.
• W2800240053 created "2018-05-17" @default.
• W2800240053 creator A5059868999 @default.
• W2800240053 date "2017-01-01" @default.
• W2800240053 modified "2023-09-24" @default.
• W2800240053 title "Estudo da migração celular induzida por Leishmania braziliensis na composição da reação inflamatória mimetizada em modelo de bolsa de ar subcutânea em hamster e a sua relação com a evolução e gravidade da infecção" @default.
• W2800240053 hasPublicationYear "2017" @default.
• W2800240053 type Work @default.
• W2800240053 sameAs 2800240053 @default.
• W2800240053 citedByCount "0" @default.
• W2800240053 crossrefType "dissertation" @default.
• W2800240053 hasAuthorship W2800240053A5059868999 @default.
• W2800240053 hasConcept C136764020 @default.
• W2800240053 hasConcept C142724271 @default.
• W2800240053 hasConcept C153911025 @default.
• W2800240053 hasConcept C203014093 @default.
• W2800240053 hasConcept C2776555147 @default.
• W2800240053 hasConcept C2777735729 @default.
• W2800240053 hasConcept C2778575167 @default.
• W2800240053 hasConcept C2778702967 @default.
• W2800240053 hasConcept C2781092759 @default.
• W2800240053 hasConcept C2781156865 @default.
• W2800240053 hasConcept C41008148 @default.
• W2800240053 hasConcept C71924100 @default.
• W2800240053 hasConcept C71928629 @default.
• W2800240053 hasConcept C86803240 @default.
• W2800240053 hasConceptScore W2800240053C136764020 @default.
• W2800240053 hasConceptScore W2800240053C142724271 @default.
• W2800240053 hasConceptScore W2800240053C153911025 @default.
• W2800240053 hasConceptScore W2800240053C203014093 @default.
• W2800240053 hasConceptScore W2800240053C2776555147 @default.
• W2800240053 hasConceptScore W2800240053C2777735729 @default.
• W2800240053 hasConceptScore W2800240053C2778575167 @default.
• W2800240053 hasConceptScore W2800240053C2778702967 @default.
• W2800240053 hasConceptScore W2800240053C2781092759 @default.
• W2800240053 hasConceptScore W2800240053C2781156865 @default.
• W2800240053 hasConceptScore W2800240053C41008148 @default.
• W2800240053 hasConceptScore W2800240053C71924100 @default.
• W2800240053 hasConceptScore W2800240053C71928629 @default.
• W2800240053 hasConceptScore W2800240053C86803240 @default.
• W2800240053 hasLocation W28002400531 @default.
• W2800240053 hasOpenAccess W2800240053 @default.
• W2800240053 hasPrimaryLocation W28002400531 @default.
• W2800240053 isParatext "false" @default.
• W2800240053 isRetracted "false" @default.
• W2800240053 magId "2800240053" @default.
• W2800240053 workType "dissertation" @default.