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- W2800266543 abstract "Ultraviolet light is the dominant environmental oxidative skin stressor and a major skin aging factor. We studied which oxidized phospholipid (OxPL) mediators would be generated in primary human keratinocytes (KC) upon exposure to ultraviolet A light (UVA) and investigated the contribution of OxPL to UVA responses. Mass spectrometric analysis immediately or 24h post UV stress revealed dynamic changes in abundance of 174 lipid species. We identified known bioactive- and novel potentially reactive lipid species, and found indication for selective metabolism and degradation of reactive lipid classes. Exposure to both UVA and to in vitro UVA - oxidized phospholipids activated, on transcriptome and proteome level, NRF2/antioxidant response signaling, lipid metabolizing enzyme expression and unfolded protein response (UPR) signaling. We identified NUPR1 as an upstream regulator of UVA/OxPL transcriptional responses and found this protein expressed in the epidermis. Silencing of NUPR1 resulted in augmented expression of antioxidant and lipid detoxification genes and disturbed the cell cycle, making it a potential key factor in skin reactive oxygen species (ROS) responses intimately involved in aging and pathology." @default.
- W2800266543 created "2018-05-17" @default.
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- W2800266543 date "2018-05-01" @default.
- W2800266543 modified "2023-09-30" @default.
- W2800266543 title "1137 A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids" @default.
- W2800266543 doi "https://doi.org/10.1016/j.jid.2018.03.1151" @default.
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