Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800281010> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2800281010 abstract "Hypertension is the most common modifiable risk factor for cardiovascular disease, with an increasing prevalence with age, but with easily available medications to control it. Adverse effects of these medications do limit their use, in particular hyponatremia due to thiazide and thiazide-like diuretics. This is more common in the elderly patients due to a combination of inadequate protein intake and impaired urinary dilution capability, made worse by additional thiazide use. Limiting free water intake and increasing protein intake are often not successful resulting in thiazide avoidance. Daily protein supplement is a potential option in this clinical scenario. We describe the protocol for a feasibility study to explore this option.This is a single-arm, prospective, open-label proof-of-concept trial, including elderly patients with thiazide diuretic-induced hyponatremia. Forty patients will be enrolled and receive a bottle of a protein supplement daily, providing 120 mmol of solutes and permitting an extra 163 mL free water loss, for 4 weeks. The main outcome measures will be (1) feasibility for enrollment, (2) safety of the intervention, and (3) potential efficacy of the intervention in improving hyponatremia. Secondary outcome measures will include changes in urine osmolality, body weight, and urea measurements.Thiazide diuretic-induced hyponatremia is an important adverse effect, with significant clinical impact, such as delirium and falls, and limits the use of these potent antihypertensive agents. There are little data on the effect or safety of protein supplementation and also on whether a trial of this is feasible. The results of this proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test protein supplementation as an effective strategy in this condition.The trial is registered with Clinical trials, registration identifier: NCT02614807." @default.
- W2800281010 created "2018-05-17" @default.
- W2800281010 creator A5007444643 @default.
- W2800281010 creator A5013058267 @default.
- W2800281010 creator A5035274018 @default.
- W2800281010 creator A5036484323 @default.
- W2800281010 creator A5037708026 @default.
- W2800281010 creator A5042691950 @default.
- W2800281010 creator A5086766337 @default.
- W2800281010 date "2018-04-06" @default.
- W2800281010 modified "2023-09-25" @default.
- W2800281010 title "Thiazide diuretic-caused hyponatremia in the elderly hypertensive: will a bottle of Nepro a day keep hyponatremia and the doctor away? Study protocol for a proof-of-concept feasibility trial" @default.
- W2800281010 cites W2001595825 @default.
- W2800281010 cites W2034551034 @default.
- W2800281010 cites W2050877607 @default.
- W2800281010 cites W2053336665 @default.
- W2800281010 cites W2080106186 @default.
- W2800281010 cites W2103881469 @default.
- W2800281010 cites W2114634962 @default.
- W2800281010 cites W2318579539 @default.
- W2800281010 cites W2322001836 @default.
- W2800281010 cites W2534656414 @default.
- W2800281010 cites W2605421222 @default.
- W2800281010 cites W2605929774 @default.
- W2800281010 cites W4238900290 @default.
- W2800281010 cites W4249101651 @default.
- W2800281010 doi "https://doi.org/10.1186/s40814-018-0263-y" @default.
- W2800281010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5889541" @default.
- W2800281010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29636984" @default.
- W2800281010 hasPublicationYear "2018" @default.
- W2800281010 type Work @default.
- W2800281010 sameAs 2800281010 @default.
- W2800281010 citedByCount "2" @default.
- W2800281010 countsByYear W28002810102019 @default.
- W2800281010 crossrefType "journal-article" @default.
- W2800281010 hasAuthorship W2800281010A5007444643 @default.
- W2800281010 hasAuthorship W2800281010A5013058267 @default.
- W2800281010 hasAuthorship W2800281010A5035274018 @default.
- W2800281010 hasAuthorship W2800281010A5036484323 @default.
- W2800281010 hasAuthorship W2800281010A5037708026 @default.
- W2800281010 hasAuthorship W2800281010A5042691950 @default.
- W2800281010 hasAuthorship W2800281010A5086766337 @default.
- W2800281010 hasBestOaLocation W28002810101 @default.
- W2800281010 hasConcept C126322002 @default.
- W2800281010 hasConcept C177713679 @default.
- W2800281010 hasConcept C197934379 @default.
- W2800281010 hasConcept C2776703092 @default.
- W2800281010 hasConcept C2779918671 @default.
- W2800281010 hasConcept C2780437262 @default.
- W2800281010 hasConcept C535046627 @default.
- W2800281010 hasConcept C71924100 @default.
- W2800281010 hasConceptScore W2800281010C126322002 @default.
- W2800281010 hasConceptScore W2800281010C177713679 @default.
- W2800281010 hasConceptScore W2800281010C197934379 @default.
- W2800281010 hasConceptScore W2800281010C2776703092 @default.
- W2800281010 hasConceptScore W2800281010C2779918671 @default.
- W2800281010 hasConceptScore W2800281010C2780437262 @default.
- W2800281010 hasConceptScore W2800281010C535046627 @default.
- W2800281010 hasConceptScore W2800281010C71924100 @default.
- W2800281010 hasLocation W28002810101 @default.
- W2800281010 hasLocation W28002810102 @default.
- W2800281010 hasLocation W28002810103 @default.
- W2800281010 hasLocation W28002810104 @default.
- W2800281010 hasLocation W28002810105 @default.
- W2800281010 hasOpenAccess W2800281010 @default.
- W2800281010 hasPrimaryLocation W28002810101 @default.
- W2800281010 hasRelatedWork W164075278 @default.
- W2800281010 hasRelatedWork W1711243923 @default.
- W2800281010 hasRelatedWork W1892939481 @default.
- W2800281010 hasRelatedWork W190917294 @default.
- W2800281010 hasRelatedWork W195654390 @default.
- W2800281010 hasRelatedWork W1983658891 @default.
- W2800281010 hasRelatedWork W1993296158 @default.
- W2800281010 hasRelatedWork W1997738446 @default.
- W2800281010 hasRelatedWork W2000885312 @default.
- W2800281010 hasRelatedWork W2009673463 @default.
- W2800281010 hasRelatedWork W2080818886 @default.
- W2800281010 hasRelatedWork W2085921098 @default.
- W2800281010 hasRelatedWork W2106022635 @default.
- W2800281010 hasRelatedWork W2128865247 @default.
- W2800281010 hasRelatedWork W2411667893 @default.
- W2800281010 hasRelatedWork W2414223873 @default.
- W2800281010 hasRelatedWork W2887460163 @default.
- W2800281010 hasRelatedWork W2978394955 @default.
- W2800281010 hasRelatedWork W2998034336 @default.
- W2800281010 hasRelatedWork W2122690796 @default.
- W2800281010 isParatext "false" @default.
- W2800281010 isRetracted "false" @default.
- W2800281010 magId "2800281010" @default.
- W2800281010 workType "article" @default.