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• W2800303504 abstract "Enzymes possess unique qualities that make them ideal regulators of supramolecular assembly. They are uniquely sensitive to biomolecules and biological compartments, catalytic in effecting chemical reactions, and present a biocompatible and degradable platform for assembly regulation. We demonstrate the novel utility of Histidine Triad Nucleotide Binding Protein 1 (HINT1) in regulating supramolecular hydrogel formation. We synthesized nucleoside-phosphoramidate-functionalized self-assembling peptides that we observed to form nanofibers. We found HINT1’s catalytic hydrolysis of the nucleoside phosphoramidate moieties within the nanofiber structures to induce nanofiber organization and higher ordered assembly. The role of HINT1 in effecting this structural change was confirmed with experiments utilizing a high-affinity HINT1 inhibitor and catalytically dead HINT1 mutant. In addition, the kinetics and morphology of hydrogel formation were found to be dependent on the structure of the released nucleoside monophosphate. This work highlights the self-assembly of phosphoramidate nanofibers and their higher organization triggered by HINT1 enzymatic activity." @default.
• W2800303504 created "2018-05-17" @default.
• W2800303504 creator A5048704704 @default.
• W2800303504 creator A5055669445 @default.
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• W2800303504 date "2018-04-24" @default.
• W2800303504 modified "2023-10-13" @default.
• W2800303504 title "Tunable Supramolecular Assemblies from Amphiphilic Nucleoside Phosphoramidate Nanofibers by Enzyme Activation" @default.
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• W2800303504 doi "https://doi.org/10.1021/acs.biomac.8b00254" @default.
• W2800303504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6628205" @default.
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