Matches in SemOpenAlex for { <https://semopenalex.org/work/W2800310789> ?p ?o ?g. }
- W2800310789 abstract "Nanoparticles (NPs) have emerged as an effective means to deliver therapeutic drugs for cancer treatment, as they can preferentially accumulate at tumor site through the enhanced permeability and retention effect. Various forms of NPs including liposomes, polymeric micelles, and inorganic particles have been used for therapeutic applications. However, the therapeutic benefits of nanomedicines are suboptimal. Although many possible reasons may account for the compromised therapeutic efficacy, the inefficient tumor penetration can be a vital obstacle. Tumor develops characteristic pathological environment, such as abnormal vasculature, elevated interstitial fluid pressure, and dense extracellular matrix, which intrinsically hinder the transport of nanomedicines in the tumor parenchyma. The physicochemical properties of the NPs such as size, shape, and surface charge have profound effect on tumor penetration. In this review, we will highlight the factors that affect the transport of NPs in solid tumor, and then elaborate on designing strategies to improve NPs' penetration and uniform distribution inside the tumor interstitium. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease" @default.
- W2800310789 created "2018-05-17" @default.
- W2800310789 creator A5022560323 @default.
- W2800310789 creator A5042241049 @default.
- W2800310789 creator A5059419843 @default.
- W2800310789 creator A5068926815 @default.
- W2800310789 creator A5079785653 @default.
- W2800310789 creator A5082372753 @default.
- W2800310789 date "2018-04-16" @default.
- W2800310789 modified "2023-10-18" @default.
- W2800310789 title "Strategies to improve tumor penetration of nanomedicines through nanoparticle design" @default.
- W2800310789 cites W1041730703 @default.
- W2800310789 cites W1137283600 @default.
- W2800310789 cites W1246937494 @default.
- W2800310789 cites W1811881863 @default.
- W2800310789 cites W1964532468 @default.
- W2800310789 cites W1965097716 @default.
- W2800310789 cites W1967921904 @default.
- W2800310789 cites W1968583232 @default.
- W2800310789 cites W1985006200 @default.
- W2800310789 cites W1989228654 @default.
- W2800310789 cites W2000192722 @default.
- W2800310789 cites W2005334224 @default.
- W2800310789 cites W2015530052 @default.
- W2800310789 cites W2016834188 @default.
- W2800310789 cites W2038163024 @default.
- W2800310789 cites W2040071171 @default.
- W2800310789 cites W2042769575 @default.
- W2800310789 cites W2054045589 @default.
- W2800310789 cites W2061593819 @default.
- W2800310789 cites W2068050569 @default.
- W2800310789 cites W2069977936 @default.
- W2800310789 cites W2082046119 @default.
- W2800310789 cites W2083710155 @default.
- W2800310789 cites W2097259163 @default.
- W2800310789 cites W2097857976 @default.
- W2800310789 cites W2098578468 @default.
- W2800310789 cites W2099487519 @default.
- W2800310789 cites W2101931537 @default.
- W2800310789 cites W2107441200 @default.
- W2800310789 cites W2112959248 @default.
- W2800310789 cites W2117630026 @default.
- W2800310789 cites W2121781418 @default.
- W2800310789 cites W2122751535 @default.
- W2800310789 cites W2126036312 @default.
- W2800310789 cites W2130784417 @default.
- W2800310789 cites W2132566055 @default.
- W2800310789 cites W2141518860 @default.
- W2800310789 cites W2143989581 @default.
- W2800310789 cites W2149597677 @default.
- W2800310789 cites W2151957316 @default.
- W2800310789 cites W2153421338 @default.
- W2800310789 cites W2155685502 @default.
- W2800310789 cites W2163326536 @default.
- W2800310789 cites W2165031969 @default.
- W2800310789 cites W2171227711 @default.
- W2800310789 cites W2231446594 @default.
- W2800310789 cites W2237967761 @default.
- W2800310789 cites W2312624944 @default.
- W2800310789 cites W2320265903 @default.
- W2800310789 cites W2324726120 @default.
- W2800310789 cites W2326188833 @default.
- W2800310789 cites W2335076883 @default.
- W2800310789 cites W2340662778 @default.
- W2800310789 cites W2342772553 @default.
- W2800310789 cites W2409322723 @default.
- W2800310789 cites W2409932367 @default.
- W2800310789 cites W2469134118 @default.
- W2800310789 cites W2519860162 @default.
- W2800310789 cites W2526834293 @default.
- W2800310789 cites W2569093456 @default.
- W2800310789 cites W2743734728 @default.
- W2800310789 cites W339936374 @default.
- W2800310789 cites W995938745 @default.
- W2800310789 doi "https://doi.org/10.1002/wnan.1519" @default.
- W2800310789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29659166" @default.
- W2800310789 hasPublicationYear "2018" @default.
- W2800310789 type Work @default.
- W2800310789 sameAs 2800310789 @default.
- W2800310789 citedByCount "162" @default.
- W2800310789 countsByYear W28003107892018 @default.
- W2800310789 countsByYear W28003107892019 @default.
- W2800310789 countsByYear W28003107892020 @default.
- W2800310789 countsByYear W28003107892021 @default.
- W2800310789 countsByYear W28003107892022 @default.
- W2800310789 countsByYear W28003107892023 @default.
- W2800310789 crossrefType "journal-article" @default.
- W2800310789 hasAuthorship W2800310789A5022560323 @default.
- W2800310789 hasAuthorship W2800310789A5042241049 @default.
- W2800310789 hasAuthorship W2800310789A5059419843 @default.
- W2800310789 hasAuthorship W2800310789A5068926815 @default.
- W2800310789 hasAuthorship W2800310789A5079785653 @default.
- W2800310789 hasAuthorship W2800310789A5082372753 @default.
- W2800310789 hasBestOaLocation W28003107891 @default.
- W2800310789 hasConcept C127413603 @default.
- W2800310789 hasConcept C15083742 @default.
- W2800310789 hasConcept C155672457 @default.
- W2800310789 hasConcept C171250308 @default.
- W2800310789 hasConcept C185154212 @default.
- W2800310789 hasConcept C185592680 @default.