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• W2800313610 endingPage "1337" @default.
• W2800313610 startingPage "1337" @default.
• W2800313610 abstract "Preterm infants often experience intermittent hypoxia (IH) with resolution in room air (RA) or hyperoxia (Hx) between events. Hypoxia is a major inducer of vascular endothelial growth factor, which plays a key role in normal and aberrant retinal angiogenesis. This study tested the hypothesis that neonatal IH which resolved with RA is less injurious to the immature retina than IH resolved by Hx between events. Newborn rats were exposed to: (1) Hx (50% O2) with brief hypoxia (12% O2); (2) RA with 12% O2; (3) Hx with RA; (4) Hx only; or (5) RA only, from P0 to P14. Pups were examined at P14 or placed in RA until P21. Retinal vascular and astrocyte integrity; retinal layer thickness; ocular and systemic biomarkers of angiogenesis; and somatic growth were determined at P14 and P21. All IH paradigms resulted in significant retinal vascular defects, disturbances in retinal astrocyte template, retinal thickening, and photoreceptor damage concurrent with elevations in angiogenesis biomarkers. These data suggest that the susceptibility of the immature retina to changes in oxygen render no differences in the outcomes between RA or O2 resolution. Interventions and initiatives to curtail O2 variations should remain a high priority to prevent severe retinopathy." @default.
• W2800313610 created "2018-05-17" @default.
• W2800313610 creator A5030446492 @default.
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• W2800313610 creator A5087629922 @default.
• W2800313610 date "2018-05-01" @default.
• W2800313610 modified "2023-10-01" @default.
• W2800313610 title "Oxygen-Induced Retinopathy from Recurrent Intermittent Hypoxia Is Not Dependent on Resolution with Room Air or Oxygen, in Neonatal Rats" @default.
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• W2800313610 doi "https://doi.org/10.3390/ijms19051337" @default.
• W2800313610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5983662" @default.
• W2800313610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29724000" @default.
• W2800313610 hasPublicationYear "2018" @default.
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