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- W2800315535 abstract "Many hormones generated in the gastrointestinal (GI) tract modulate appetite in humans. The site of production, mechanism of action and effects of the most relevant of these anorectic and orexigenic GI hormones are revised in this article. Moreover, for each of these relevant hormones, information will be provided on the variations in their levels induced by obesity and by the changes induced by dietary restriction, physical exercise, and bariatric surgery. The balance between GI hormones seems altered in patients with obesity, where a tendency toward reduced anorectic pathways and increased orexigenic signals have been reported. Attempts to reduce body weight trough dietary restriction tend to accentuate this alteration, with a further reduction in anorectic hormones and an increase of the orexigenic ones. These diet-induced changes in GI hormones are considered one of the most important factor causing weight regain and obesity recidivism after diet-induced weight loss. A different picture may be observed after bariatric surgery, particularly after sleeve gastrectomy and gastric bypass, where anorectic hormones are stimulated and orexigenic signals suppressed. These changes may partly explain the superiority of bariatric surgery over lifestyle modifications in maintaining weight loss over time. Therefore, GI hormones regulation seem important both in physiology and in the obese state." @default.
- W2800315535 created "2018-05-17" @default.
- W2800315535 creator A5025875546 @default.
- W2800315535 creator A5040398270 @default.
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- W2800315535 date "2019-01-01" @default.
- W2800315535 modified "2023-09-27" @default.
- W2800315535 title "Gastrointestinal Hormones and Their Regulation of Food Intake" @default.
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- W2800315535 doi "https://doi.org/10.1016/b978-0-12-801238-3.66106-8" @default.
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